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pro vyhledávání: '"N J Zvaifler"'
Autor:
N. J. Zvaifler
Publikováno v:
Scandinavian Journal of Rheumatology. 24:67-75
(1995). Macrophages and the Synovial Lining. Scandinavian Journal of Rheumatology: Vol. 24, No. sup101, pp. 67-75.
Publikováno v:
The Journal of Immunology. 149:1424-1431
Expression of vascular cell adhesion molecule-1 (VCAM-1) in synovial tissue was determined using the immunoperoxidase technique. Normal, rheumatoid arthritis (RA), and osteoarthritis (OA) synovia bound VCAM-1 antibodies in the intimal lining as well
Autor:
G S Firestein, A E Berger, D E Tracey, J G Chosay, D L Chapman, M M Paine, C Yu, N J Zvaifler
Publikováno v:
The Journal of Immunology. 149:1054-1062
IL-1 can participate in the perpetuation of arthritis through direct stimulation of synoviocytes and augmentation of matrix degradation. Hence, local production of the IL-1R antagonist protein (IRAP) might be an important negative feedback signal tha
Autor:
N J, Zvaifler
Publikováno v:
The Journal of Experimental Medicine
Measurements were made of the IgG in synovial fluid which is synthesized by the intact rheumatoid synovium. In five rheumatoid subjects 12–24% of the IgG present in their synovial fluid was derived from local production. No evidence for local produ
Publikováno v:
The Journal of Immunology. 146:3365-3371
Granulocyte-macrophage CSF (GM-CSF) is a potent stimulator of macrophages and neutrophils and is produced by rheumatoid arthritis (RA) synovium. We now report studies that identify some of the synovial cells and cytokines responsible for local GM-CSF
Autor:
C Fix, Michael H. Weisman, N J Zvaifler, T.J. Riccio, Donald Resnick, Melinda E. Sanders, S Kursunoglu-Brahme
Publikováno v:
Radiology. 176:831-835
Physical examination is often insufficient in distinguishing between joint effusion and inflamed synovium in the knee joints of patients with rheumatoid arthritis. The authors prospectively evaluated the role of intravenously administered gadopenteta
Autor:
Maripat Corr, N J Zvaifler
Publikováno v:
Annals of the rheumatic diseases. 61(1)
What are mesenchymal precursor (stem) cells doing in rheumatoid arthritis joints? Genes implicated in limb development and bone and joint formation,1,2 particularly members of the segment polarity family that encode components of the hedgehog and win
Publikováno v:
Blood. 96(8)
A subset of blood cells from patients with B-cell chronic lymphocytic leukemia (CLL) spontaneously differentiates in vitro into large, round, or fibroblast-like adherent cells that display stromal cell markers, namely vimentin and STRO-1. These cells
Publikováno v:
Arthritis and rheumatism. 43(9)
To evaluate the presence of cells of an early mesenchymal lineage, as judged by the expression of bone morphogenetic protein receptors (BMPRs), in the joints of normal individuals and patients with rheumatoid arthritis (RA).Synovial fluids, single ce
Autor:
P P, Tak, T J, Smeets, D L, Boyle, M C, Kraan, Y, Shi, S, Zhuang, N J, Zvaifler, F C, Breedveld, G S, Firestein
Publikováno v:
Arthritis and rheumatism. 42(5)
The p53 tumor suppressor gene is overexpressed in synovial tissue (ST) from patients with longstanding rheumatoid arthritis (RA), and may contain somatic mutations. The aim of this study was to determine p53 expression in ST from RA patients in diffe