Zobrazeno 1 - 10
of 16
pro vyhledávání: '"N J Welsh"'
Autor:
Ingvar Bjarnason, Gudmunder Sigthorsson, Iggy Tavares, N J Welsh, A Palizban, F Borrelli, Robert J. Simpson
Publikováno v:
Alimentary Pharmacology & Therapeutics. 14:1365-1370
Background: Constitutive cyclooxygenase-1 enzyme synthesizes prostaglandins which are thought to play an important role in the functional integrity of the stomach gastric mucosa. Recently, it was shown that cyclooxygenase-1 deficient mutant mice did
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a026051b097c2055fcea49853a9e7115
https://doi.org/10.1046/j.1365-2036.2000.00836.x
https://doi.org/10.1046/j.1365-2036.2000.00836.x
Autor:
Renee Sharon Martin, S J MacLennan, Richard M. Eglen, L. A. Luong, N J Welsh, Graeme R. Martin
Publikováno v:
British Journal of Pharmacology. 129:1707-1715
This study investigated the cannabinoid receptor, known to inhibit neuronally-evoked contractions of the mouse isolated urinary bladder, in bladder sections isolated from mouse, rat, dog, pig non-human primate or human. The CB(1)-like pharmacology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33bf09f829ed225a4455c1ae607d4792
https://doi.org/10.1038/sj.bjp.0703229
https://doi.org/10.1038/sj.bjp.0703229
Autor:
N J Welsh, L.M.A. Akkermans, N H Prins, M.R. Briejer, N.P. Shankley, J. A. J. Schuurkes, Romain Lefebvre
Publikováno v:
British Journal of Pharmacology. 129:1601-1608
Recently, it was demonstrated that 5-HT induces relaxation of human colon circular muscle through activation of 5-HT(4) receptors and 5-HT(7) receptors. The aim of the current study was to develop a new in vitro bioassay of human colon that would fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a73edee62c632da6368c491fa8a999d
https://doi.org/10.1038/sj.bjp.0703254
https://doi.org/10.1038/sj.bjp.0703254
Publikováno v:
British Journal of Pharmacology. 124:729-741
1. Dipyridamole potentiates the effects of adenosine on the heart by inhibiting adenosine uptake. The effects of dipyridamole on both adenosine and N-ethylcarboxamidoadenosine (NECA) concentration-effect (E/[A]) curves were compared on the AV node, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa7e5d8e90ef21b9eb72b8415df5ab9
https://doi.org/10.1038/sj.bjp.0701892
https://doi.org/10.1038/sj.bjp.0701892
Publikováno v:
British Journal of Pharmacology. 124:685-692
1. The effects of seven agonist and three antagonist adenosine receptor ligands were compared on the guinea-pig sinoatrial (SA) node (isolated right atrium) and atrioventricular (AV) node (perfused whole heart). Single agonist concentration-effect cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0b6a820141f4fe8848b386c3c0ce78
https://doi.org/10.1038/sj.bjp.0701891
https://doi.org/10.1038/sj.bjp.0701891
Publikováno v:
British Journal of Pharmacology. 115:961-968
1 Concentration-effect curves were obtained, in the absence and presence of histamineH2-receptor blockade, to 5-methylfurmethide (5-MeF) and McN-A 343, high efficacy and low efficacy acetylcholine (ACh) M-receptor agonists, respectively, in isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c638388e4d68b6f01ee27b7a056f7897
https://doi.org/10.1111/j.1476-5381.1995.tb15904.x
https://doi.org/10.1111/j.1476-5381.1995.tb15904.x
Autor:
BORRELLI, FRANCESCA, N. J. Welsh, G. Sigthorsson, R. Simpson, A. Palizban, I. Bjarnason, I. A. Tavares
Publikováno v:
Alimentary pharmacologytherapeutics. 14(10)
Constitutive cyclooxygenase-1 enzyme synthesizes prostaglandins which are thought to play an important role in the functional integrity of the stomach gastric mucosa. Recently, it was shown that cyclooxygenase-1 deficient mutant mice did not develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cd8413510be45fba4469aaa9352ce228
https://pubmed.ncbi.nlm.nih.gov/11012484
https://pubmed.ncbi.nlm.nih.gov/11012484
Publikováno v:
British Journal of Pharmacology. 109:941-945
1. Isolated, lumen-perfused, whole stomach preparations from mouse and immature rat produced a stable basal acid output which, although not blocked by histamine H2-, acetylcholine M- or CCKB/gastrin receptor antagonists, was almostly completely block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbffbe1a28dd721b9796ce8146ec2b4
https://doi.org/10.1111/j.1476-5381.1993.tb13711.x
https://doi.org/10.1111/j.1476-5381.1993.tb13711.x
Publikováno v:
Regulatory peptides. 105(1)
Cholecystokinin (CCK) produces contractions of gallbladder and colon in a number of different species. Although the effects of CCK on the human gallbladder are relatively well documented, the CCK receptors in the human colon have not been clearly cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8797700e889bd3e7f884bff566f76b4d
https://pubmed.ncbi.nlm.nih.gov/11853872
https://pubmed.ncbi.nlm.nih.gov/11853872
Autor:
N H, Prins, N P, Shankley, N J, Welsh, M R, Briejer, R A, Lefebvre, L M, Akkermans, J A, Schuurkes
Publikováno v:
British journal of pharmacology. 129(8)
Recently, it was demonstrated that 5-HT induces relaxation of human colon circular muscle through activation of 5-HT(4) receptors and 5-HT(7) receptors. The aim of the current study was to develop a new in vitro bioassay of human colon that would fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b608e936072049db349f74872e023260
https://pubmed.ncbi.nlm.nih.gov/10780964
https://pubmed.ncbi.nlm.nih.gov/10780964