Výsledky vyhledávání

Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations

Autor: G, Lal, L, Liu, D, Hogg, N J, Lassam, M S, Redston, S, Gallinger

Publikováno v: Genes, chromosomescancer. 27(4)

Germline mutations of the CDKN2A tumor suppressor gene have been identified in melanoma kindreds linked to 9p21, and pancreatic adenocarcinoma is the second most common malignancy in some of these families. We hypothesized that unselected patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::011384b9c3b16217810b1aff59834e16
https://pubmed.ncbi.nlm.nih.gov/10719365

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Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial

Autor: I. C. Quirt, Frank L. Graham, Lorne E. Rotstein, Denis Bailey, N J Lassam, Steven Gallinger, D. Cappe, Christina L. Addison, Sophie Dessureault, Yonghong Wan, R C Moen, M. Krajden, Jack Gauldie, A K Stewart

Publikováno v: Gene therapy. 6(3)

We conducted a phase 1 trial of direct injection of an E1, E3-deleted adenovirus encoding interleukin-2 (AdCAIL-2) into subcutaneous deposits of melanoma or breast cancer. Twenty-three patients were injected at seven dose levels (10(7)-10(10) p.f.u).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f0f7327bd3223bea6420128ca02b7
https://pubmed.ncbi.nlm.nih.gov/10435085

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CDKN2A mutation in a non-FAMMM kindred with cancers at multiple sites results in a functionally abnormal protein

Autor: S, Sun, P M, Pollock, L, Liu, S, Karimi, S, Jothy, B J, Milner, A, Renwick, N J, Lassam, N K, Hayward, D, Hogg, S A, Narod, W D, Foulkes

Publikováno v: International journal of cancer. 73(4)

The CDKN2A gene encodes p16 (CDKN2A), a cell-cycle inhibitor protein which prevents inappropriate cell cycling and, hence, proliferation. Germ-line mutations in CDKN2A predispose to the familial atypical multiple-mole melanoma (FAMMM) syndrome but al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca681ad29c434ee3712ceba107c66d5b
https://pubmed.ncbi.nlm.nih.gov/9389568

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A phase I study of adenovirus mediated gene transfer of interleukin 2 cDNA into metastatic breast cancer or melanoma

Autor: A K, Stewart, N J, Lassam, F L, Graham, J, Gauldie, C L, Addison, D J, Bailey, S, Dessureault, I D, Dubé, S, Gallenger, M, Krajden, L E, Rotstein, I C, Quirt, R, Moen

Publikováno v: Human gene therapy. 8(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9f4ba5bf8f33b49ade51252916fbac0
https://pubmed.ncbi.nlm.nih.gov/9295135

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Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma

Autor: L, Gao, L, Liu, D, van Meyel, G, Cairncross, P, Forsyth, D, Kimmel, R B, Jenkins, N J, Lassam, D, Hogg

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(6)

Gliomas are tumors of the central nervous system that may be inherited in some patients. The gene(s) responsible for the clustering of gliomas in families have not yet been identified. Molecular studies of sporadic high-grade gliomas have revealed mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f68ba295bb56a28adf215c08058cb99
https://pubmed.ncbi.nlm.nih.gov/9815774

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Affected members of melanoma-prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19ARF

Autor: L, Liu, A M, Goldstein, M A, Tucker, H, Brill, N A, Gruis, D, Hogg, N J, Lassam

Publikováno v: Genes, chromosomescancer. 19(1)

Mutations in the gene encoding the cell cycle inhibitor CDKN2A have been identified in some melanoma kindreds linked to 9p21. However, many such families show no evidence of mutations in the coding regions of CDKN2A. In this study, we examined whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2362d2a72fe6e1c46e26540a7d171fda
https://pubmed.ncbi.nlm.nih.gov/9135995

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MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

Autor: L A, Tibbles, Y L, Ing, F, Kiefer, J, Chan, N, Iscove, J R, Woodgett, N J, Lassam

Publikováno v: The EMBO journal. 15(24)

Mixed lineage kinase-3 (MLK-3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function. Cdc42 and the related small GTP binding protein Rac1 can activate the SAPK/JNK and p38/RK str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb65e0684fb391207e7adae59d772fce
https://pubmed.ncbi.nlm.nih.gov/9003778

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Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma

Autor: L, Liu, N J, Lassam, J M, Slingerland, D, Bailey, D, Cole, R, Jenkins, D, Hogg

Publikováno v: Oncogene. 11(2)

The gene encoding the cell cycle inhibitor p16INK4A (also known as p16, MTS1, CDKN2 and INK4) has been mapped to human chromosome band 9p21, a region that also contains a putative melanoma susceptibility gene. Although germline mutations in the codin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d18ae12d9805bde98d9ad9c43023ed11
https://pubmed.ncbi.nlm.nih.gov/7624155

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