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A human CD4 + T‐cell line expresses functional CD64 (Fc γ RI), CD32 (Fc γ RII), and CD16 (Fc γ RIII) receptors but these do not enhance the infectivity of HIV‐1‐IgG complexes

Autor: N J Dimmock, L McLain

Publikováno v: Immunology. 90:109-114

T cells do not generally express Fc receptors (FcRs). However, we report here that C8166 cells, a human CD4+ T lymphoblastoid cell line, widely used in research into the human immunodeficiency virus type 1 (HIV-1), expressed CD64 (Fc gamma RI), CD32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87720aa21f88dd8682ea9d2429edf75b
https://doi.org/10.1046/j.1365-2567.1997.00116.x

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Varying temperature-dependence of post-attachment neutralization of human immunodeficiency virus type 1 by monoclonal antibodies to gp120: identification of a very early fusion-independent event as a neutralization target

Autor: S. J. Armstrong, N. J. Dimmock

Publikováno v: Journal of General Virology. 77:1397-1402

Neutralization of human immunodeficiency virus type 1 by adding antibody after the virus has attached to the host cell (post-attachment neutralization:PAN) was investigated using three rat monoclonal antibodies (MAbs) directed against the outer domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743f272311ca6fdc505de363438c11fa
https://doi.org/10.1099/0022-1317-77-7-1397

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Defective interfering type A equine influenza virus (H3N8) protects mice from morbidity and mortality caused by homologous and heterologous subtypes of influenza A virus

Autor: N. J. Dimmock, Simon Noble

Publikováno v: Journal of General Virology. 75:3485-3491

Intranasal administration of defective interfering A/equine/Newmarket/7339/79 (H3N8) influenza virus (DI EQV) protected mice from otherwise lethal intranasal infection with homologous virus (EQV) or with the heterologous subtypes A/WSN (H1N1) or A/PR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021cf66e4b41a740fd55052af654a7a5
https://doi.org/10.1099/0022-1317-75-12-3485

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Single- and multi-hit kinetics of immunoglobulin G neutralization of human immunodeficiency virus type 1 by monoclonal antibodies

Autor: Lesley McLain, N. J. Dimmock

Publikováno v: Journal of General Virology. 75:1457-1460

A quantal assay, based on syncytium formation in the human T cell leukaemia-derived C8166 cell line, was used to determine the kinetics of human immuno-deficiency virus type 1 (HIV-1) strain IIIB neutralization. Three rat monoclonal antibodies (MAbs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ca1219f76423a2852ec02d900d3717
https://doi.org/10.1099/0022-1317-75-6-1457

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A monoclonal antibody produced during infection which recognizes an epitope of influenza hemagglutinin only in the context of H-2k MHC class I antigen

Autor: L McLain, N J Dimmock

Publikováno v: The Journal of Immunology. 150:3421-3426

A hybridoma prepared from cells isolated from the lungs of H-2k mice infected with influenza virus (A/WSN) produces a monoclonal IgM (LM41) which recognizes an epitope of the A/WSN hemagglutinin (HA) Ag only when it is expressed in H-2k cells, as sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0117c9066e13fd77fc8703c4c06ce873
https://doi.org/10.4049/jimmunol.150.8.3421

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Mechanisms of neutralization of a nairovirus (Dugbe virus) by polyclonal IgG and IgM

Autor: E. M. Green, N. J. Dimmock, S. J. Armstrong

Publikováno v: Journal of General Virology. 73:1995-2001

Dugbe virus is a member of the nairovirus genus of the Bunyaviridae. Purified polyclonal anti-Dugbe virus IgG, which neutralized greater than 99.5% of virus, reduced attachment of virus to BSC-1 cell monolayers by only 36%. A 100-fold lower concentra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64663f2250ee6f3ff2a3d8d66ac9be73
https://doi.org/10.1099/0022-1317-73-8-1995

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Defective interfering viruses and their potential as antiviral agents

Autor: A C, Marriott, N J, Dimmock

Publikováno v: Reviews in medical virology. 20(1)

Defective interfering (DI) virus is simply defined as a spontaneously generated virus mutant from which a critical portion of the virus genome has been deleted. At least one essential gene of the virus is deleted, either in its entirety, or sufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78dc60960a9b71bc7f732462e326ffdb
https://pubmed.ncbi.nlm.nih.gov/20041441

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Mechanisms of Neutralization of Influenza Virus on Mouse Tracheal Epithelial Cells by Mouse Monoclonal Polymeric IgA and Polyclonal IgM Directed Against the Viral Haemagglutinin

Autor: M. C. Outlaw, N. J. Dimmock

Publikováno v: Journal of General Virology. 71:69-76

The mechanism of neutralization of a type A influenza virus by polyclonal IgM was similar for both tracheal epithelial and BHK cells. Maximum neutralization was only 90% and most (70%) of the virus failed to attach to inoculated cells. The remainder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6b6f10f1fc8eafff29d483e3373ce9
https://doi.org/10.1099/0022-1317-71-1-69

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A monoclonal antibody produced during infection which recognizes an epitope of influenza hemagglutinin only in the context of H-2k MHC class I antigen

Autor: L, McLain, N J, Dimmock

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 150(8 Pt 1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b5bdb22676e65457e277c6fec43597f
https://pubmed.ncbi.nlm.nih.gov/7682240

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