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pro vyhledávání: '"N J, Wells"'
Autor:
N J, Wells, I D, Hickson
Publikováno v:
European Journal of Biochemistry. 231:491-497
Topoisomerase II is essential for chromosome condensation and segregation at mitosis in eukaryotic cells, but the mechanism of its regulation is not clearly understood. We have investigated whether or not the alpha isozyme of human topoisomerase II i
Autor:
N J, Wells, I D, Hickson
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 94
Publikováno v:
Molecular cell. 2(6)
We have identified a novel human protein, PRC1, that is involved in cytokinesis. PRC1 is a good substrate for several CDKs in vitro and is phosphorylated in vivo at sites that are phosphorylated by CDK in vitro, strongly suggesting that PRC1 is an in
Publikováno v:
The Journal of biological chemistry. 270(47)
Type II topoisomerases are essential for faithful cell division in all organisms. In human cells, the alpha isozyme of topoisomerase II has been implicated in catalyzing mitotic chromosome segregation via its action as a DNA unlinking enzyme. Here, w
Publikováno v:
Anti-cancer drugs. 6(2)
Topoisomerase II enzymes play an essential role in human DNA metabolism. They are also recognized as primary targets of a number of anti-cancer drugs used in the treatment of breast cancer, which remains a leading cause of cancer-related death in wom
Publikováno v:
Canadian journal of surgery. Journal canadien de chirurgie. 37(6)
To review recent experience with pilomatrixoma, particularly with respect to diagnosis.Chart review for an 8-year period.A university-affiliated children's hospital.Fifty children with 51 histologically proven pilomatrixomas.Excision of the lesion.Cl
Publikováno v:
The Journal of biological chemistry. 269(47)
Topoisomerase II protein is essential for cell proliferation and is known to exist as a phosphoprotein in cells from both lower and higher eukaryotic species. In this paper, we have investigated the phosphorylation of the alpha isozyme of human topoi