Zobrazeno 1 - 10
of 61
pro vyhledávání: '"N J, McHugh"'
Publikováno v:
Annals of the Rheumatic Diseases. 55:507-512
OBJECTIVE: To describe and quantify the morphological characteristics of nailfold capillaries that distinguish different forms of connective tissue disease from healthy controls. METHODS: A CCD video microscope with fibreoptic illumination and PC bas
Publikováno v:
Arthritis & Rheumatism. 38:1845-1850
Objective. To study the serologic status of 3 previously unreported monozygotic twin pairs discordant for systemic sclerosis (SSc). Methods. Autoantibodies were measured by indirect immunofluorescence, immunodiffusion, and immunoprecipitation of 35S-
Autor:
James J. Champoux, Lance Stewart, N. D. Hall, J Whyte, William C. Earnshaw, Leon H. Parker, N J McHugh
Publikováno v:
Scopus-Elsevier
SUMMARYTopoisomerase I (topo I) is a major systemic sclerosis (SSc)-associated autoantigen. A cDNA construct encoding full length human topo I in a recombinant baculovirus transfer vector was used to infect insect cells in culture from which recombin
Autor:
C. O. Stephens, Ken I. Welsh, N J McHugh, Peter J. Maddison, J Whyte, Georgina Harvey, Carol M. Black, Carol M. Artlett
Publikováno v:
Journal of Autoimmunity. 7:509-520
The frequency and functional properties of anti-topoisomerase-1 antibodies (ATA) have been studied in 58 systemic sclerosis (SSc) probands, 218 first degree relatives and 22 spouses. The dependence of ATA on the presence of certain HLA-DRB1 and HLA-D
Publikováno v:
Rheumatology. 33:255-259
Cervical spondylitis has been reported in 35-75% of patients with PsA. The clinical and radiological changes of the cervical spine were evaluated in 75 patients with PsA. Cervical spine involvement was found in 45% of those examined and 36% of patien
Autor:
Peter J. Maddison, Carol M. Black, J Whyte, C. O. Stephens, David Briggs, Georgina Harvey, N J McHugh, Ken I. Welsh
Publikováno v:
Medicine. 72:103-112
Systemic sclerosis (SSc) tends to occur in a sporadic fashion and familial occurrence of the disease is unusual. Nevertheless, reports of related connective tissue diseases (CTD), autoantibodies, or both in family members together with associations o
Publikováno v:
Rheumatology. 39:108-110
Autor:
H, Gunawardena, L R, Wedderburn, H, Chinoy, Z E, Betteridge, J, North, W E R, Ollier, R G, Cooper, C V, Oddis, A V, Ramanan, J E, Davidson, N J, McHugh, Sue, Maillard
Publikováno v:
Arthritis and Rheumatism
Juvenile dermatomyositis (DM) is the most common of the idiopathic inflammatory myopathies (IIMs) of children. The reported incidence is 0.8–4.1 per million children per year (1–3). Juvenile DM is chronic, potentially debilitating, and can be ass
Publikováno v:
Clinical and experimental rheumatology. 21(3 Suppl 29)
Candidate markers for endothelial cell, lymphocyte and fibroblast function in systemic sclerosis have been reviewed. Autoantibody measurement and general inflammatory markers were considered the minimum requirements, with other markers needing furthe
Autor:
M J, Hubbard, N J, McHugh
Publikováno v:
Electrophoresis. 21(17)
Recently we characterised a novel 29 kDa endoplasmic reticulum protein that is widely expressed in rat tissues, and named it ERp29. Several ERp29-like gene products have been reported in human tissues but uncertainty surrounds their relationships wit