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Publikováno v:
Environmental and molecular mutagenesis. 36(4)
The placenta is a readily available source of material for molecular epidemiological investigations. As such, DNA damage in this tissue can be indicative of maternal exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs)
Publikováno v:
Integrated Photonics Research.
The deployment of the EDFA in WDM systems has to date required passive spectral gain equalisation/flattening.
Publikováno v:
Cancer research. 55(6)
The aim of this study was to determine whether buccal mucosa would provide an alternate source of tissue for human biomonitoring. Samples of clinically normal oral biopsies were excised, and buccal mucosa were scraped or brushed from patients while t
Publikováno v:
Cancer research. 53(7)
Samples of clinically normal oral tissue were obtained from patients undergoing surgery for intraoral squamous cell carcinoma. DNA was extracted from samples obtained from 20 tobacco smokers, four exsmokers, and nine nonsmokers and analyzed for the p
Publikováno v:
IARC scientific publications. (124)
Samples of clinically normal oral tissue were obtained from 17 tobacco smokers and 7 non- or ex-smokers undergoing surgery for intra-oral squamous cell carcinoma. Isolated DNA was analysed for the presence of aromatic DNA adducts using the 32P-postla
Publikováno v:
IARC scientific publications. (127)
1,2-Epoxy-3-butene and 1,2:3,4-diepoxybutane, the two oxidative metabolites of 1,3-butadiene, are considered to be involved in some of the carcinogenicity of the parent compound. Diepoxybutane is a bifunctional alkylating agent and reacts with DNA to
Publikováno v:
IARC scientific publications. (124)
We have developed an HPLC-32P-postlabelling procedure to detect DNA adducts formed by epoxybutene and diepoxybutane. The method exploits the interaction of the two epoxides with deoxynucleotides and polydeoxynucleotides to optimize the HPLC enrichmen
Publikováno v:
Journal of Cell Science. 1987:177-189
SUMMARY We have utilized DNA transfer and recombinant DNA techniques to probe DNA double-strand break repair in the human ionizing radiation-sensitive genetic syndrome ataxia-telangiectasia (A-T). Using restriction enzyme-generated double-strand brea
Publikováno v:
Mutation research. 199(1)
DNA double-strand break repair was assessed in 2 new radiation-sensitive V79 hamster cell lines ( irsl and irs2 ) by their ability to rejoin restriction endonuclease cuts in a transferred selectable SV40- E. coli gpt recombinant gene. The studied gen