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Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer

Autor: D M, Shin, N J, Donato, R, Perez-Soler, H J, Shin, J Y, Wu, P, Zhang, K, Lawhorn, F R, Khuri, B S, Glisson, J, Myers, G, Clayman, D, Pfister, J, Falcey, H, Waksal, J, Mendelsohn, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)

C225, a human-mouse chimerized monoclonal antibody directed against the epidermal growth factor receptor (EGFr), has a synergistic effect with cisplatin in xenograft models. To determine the tumor EGFr saturation dose with C225 and the fate of infuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4684c649ce32a7c3eaebf743d3c0112e
https://pubmed.ncbi.nlm.nih.gov/11350885

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EGF receptor and p21WAF1 expression are reciprocally altered as ME-180 cervical carcinoma cells progress from high to low cisplatin sensitivity

Autor: N J, Donato, M, Perez, H, Kang, Z H, Siddik, Y H, Ling, R, Perez-Soler

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(1)

Cell cycle regulators and signal transduction pathways can influence apoptotic sensitivity of tumor cells, and we previously described an association between EGFr overexpression, reduced DNA repair activity, and increased apoptotic sensitivity of ME-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a2a12d2c08b673dcc0318e037857b54
https://pubmed.ncbi.nlm.nih.gov/10656450

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Regulation of epidermal growth factor receptor activity by crotoxin, a snake venom phospholipase A2 toxin. A novel growth inhibitory mechanism

Autor: N J, Donato, C A, Martin, M, Perez, R A, Newman, J C, Vidal, M, Etcheverry

Publikováno v: Biochemical pharmacology. 51(11)

Crotoxin (CT), a phospholipase A2 (PLA2) derived from the venom of Crotalus durissus terrificus, is a heterodimeric protein composed of subunit B with enzymatic activity and a binding regulatory subunit (A) without enzyme activity. Although the PLA2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c3f24e02c899463504dbf347390020b
https://pubmed.ncbi.nlm.nih.gov/8630095

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Positive and negative selection for tumor necrosis factor responsiveness reveals an inhibitory role for EGF receptor in TNF-induced antiproliferation

Autor: K, Nishikawa, J, Rotbein, D, Vijjeswarapu, L, Owen-Schaub, M G, Rosenblum, N J, Donato

Publikováno v: Lymphokine and cytokine research. 13(1)

Tumor necrosis factor (TNF) induces dose-dependent, but incomplete cytotoxicity in ME-180 cervical carcinoma cells resulting in a significant reduction in cell viability. In this cell line there exists a characteristic residual tumor cell population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::994a2f5d9e54d86647fcd1efeb532bdf
https://pubmed.ncbi.nlm.nih.gov/8186323

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Epidermal growth factor receptor expression and function control cytotoxic responsiveness to tumor necrosis factor in ME-180 squamous carcinoma cells

Autor: N J, Donato, D H, Yan, M C, Hung, M G, Rosenblum

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 4(5)

Tumor necrosis factor (TNF) induces dose-dependent but incomplete cytotoxicity in ME-180 cervical carcinoma cells, suggesting that TNF response heterogeneity exists within this cell line. To investigate cellular properties associated with TNF-mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ec031469b1a82375cf203036dcf67f8
https://pubmed.ncbi.nlm.nih.gov/8518234

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Resistance of human cervical carcinoma cells to tumor necrosis factor correlates with their increased sensitivity to cisplatin: evidence of a role for DNA repair and epidermal growth factor receptor

Autor: K, Nishikawa, M G, Rosenblum, R A, Newman, T K, Pandita, W N, Hittelman, N J, Donato

Publikováno v: Cancer research. 52(17)

Alterations in cellular biochemistry which are associated with the development of resistance to cytotoxic peptides, such as tumor necrosis factor (TNF), may also be responsible for changes in the response of cells to cytotoxic agents. Culturing ME-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::477ed80fd6b71ebf9e1ce5e11524344f
https://pubmed.ncbi.nlm.nih.gov/1380890

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Tumor necrosis factor regulates tyrosine phosphorylation on epidermal growth factor receptors in A431 carcinoma cells: evidence for a distinct mechanism

Autor: N J, Donato, M G, Rosenblum, P A, Steck

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 3(5)

Previous studies of tumor necrosis factor (TNF) action on tumor cells revealed a possible role for tyrosine phosphorylation of epidermal growth factor (EGF) receptor in the growth-regulatory activities of this cytokine (N. J. Donato, G. E. Gallick, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1070a588e06841c30135c4b8c6ab4a45
https://pubmed.ncbi.nlm.nih.gov/1378752

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Growth state-dependent alterations in the ability of 12-O-tetradecanoylphorbol-13-acetate to increase ornithine decarboxylase activity in Reuber h35 Hepatoma cells

Autor: V S, Wu, N J, Donato, C V, Byus

Publikováno v: Cancer research. 41(9 Pt 1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b5700e11fe1dc928c437f37d8f83c04
https://pubmed.ncbi.nlm.nih.gov/6266654

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Tumor necrosis factor alpha: a multifaceted peptide hormone

Autor: M G, Rosenblum, N J, Donato

Publikováno v: Critical reviews in immunology. 9(1)

Homeostasis at the cellular level appears to be a complex state of equilibrium derived, in part, from multiple interactions among lymphokines, cytokines, growth factors, and hormones. Tumor necrosis factor (TNF-alpha) secreted by mitogen-stimulated m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b77e9eb6c0488e584aa490aca2af22d
https://pubmed.ncbi.nlm.nih.gov/2539946

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Tumor necrosis factor modulates epidermal growth factor receptor phosphorylation and kinase activity in human tumor cells. Correlation with cytotoxicity

Autor: N J, Donato, G E, Gallick, P A, Steck, M G, Rosenblum

Publikováno v: The Journal of biological chemistry. 264(34)

Tumor necrosis factor (TNF) is a cytokine which induces cytotoxicity in some but not all tumor cells. Initial studies of five tumor cell lines demonstrated that TNF was able to rapidly (within 30 min) modulate tyrosine protein kinase activity of epid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25853c3222c6b1568d142b13090ee5b1
https://pubmed.ncbi.nlm.nih.gov/2555361

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