Zobrazeno 1 - 10
of 67
pro vyhledávání: '"N J, Abbott"'
Publikováno v:
Current Drug Metabolism. 9:901-910
Drug discovery programmes to target or avoid the brain need to take into account the properties of the blood-brain barrier (BBB). The importance to CNS PK of the free drug concentration in brain is increasingly recognised, and assays for drug discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa1a81d2f4dd07a705dde4d716a022a
https://doi.org/10.2174/138920008786485182
https://doi.org/10.2174/138920008786485182
Publikováno v:
Glia. 39:99-104
The blood-brain barrier (BBB) is formed by the presence of tight junction complexes between brain endothelial cells that restrict paracellular permeability. As a consequence, a number of transport proteins are expressed on cerebral endothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a30ae4fdedaf8611e43c202c0e71551
https://doi.org/10.1002/glia.10090
https://doi.org/10.1002/glia.10090
Autor:
N. J. Abbott
Publikováno v:
Journal of Anatomy. 200:523-534
The blood-brain barrier (BBB) is formed by brain endothelial cells lining the cerebral microvasculature, and is an important mechanism for protecting the brain from fluctuations in plasma composition, and from circulating agents such as neurotransmit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da9cd8aa4caa7241288ed074b43889c
https://doi.org/10.1046/j.1469-7580.2002.00047_13.x
https://doi.org/10.1046/j.1469-7580.2002.00047_13.x
Publikováno v:
Neurochemistry International. 33:473-478
An improved method for culturing primary rat brain capillary endothelial cells on glass has been developed, using a corneal extracellular matrix coat. Since the collagen-coated plastic attachment surface conventionally used for primary cultures of br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d135b91a64a2f8c01333acd07a21012
https://doi.org/10.1016/s0197-0186(98)00057-6
https://doi.org/10.1016/s0197-0186(98)00057-6
Publikováno v:
Brain Research. 756:133-140
The possible involvement of blood-brain barrier (BBB) breakdown in the pathogenesis of thiamine deficiency encephalopathy was investigated in RBE4 cells, an immortalized rat brain endothelial cell line. The effects of thiamine deficiency produced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bc7cee669938763f40691f7b1ad4fc
https://doi.org/10.1016/s0006-8993(97)00127-3
https://doi.org/10.1016/s0006-8993(97)00127-3
Publikováno v:
Journal of Neurocytology. 24:347-360
A comparison was made between endothelial cells in freshly-isolated rat brain microvessels, and following culture of the cells for 1-10 days during growth to confluence. Attention focused on tight junctions and vesicular structures, as seen in thin s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b871cffe771b833de77e628dbe6cd0b7
https://doi.org/10.1007/bf01189062
https://doi.org/10.1007/bf01189062