Zobrazeno 1 - 10
of 16
pro vyhledávání: '"N I Hutchinson"'
Autor:
N I Hutchinson, S W Ryder
Publikováno v:
Clinical Pharmacology & Therapeutics. 81:756-760
Obesity is an epidemic with tremendous impact on both patients and health-care systems globally. This paper explores some of the questions related to the clinical development of new pharmacotherapies in the context of an evolving regulatory perspecti
Autor:
H R Williams, C F Harper, John G. Flanagan, J R Weidner, E K Bayne, N I Hutchinson, S A Donatelli, I I Singer, L A Hoerrner, Michael W. Lark, L. S. Lohmander, R A Mumford
Publikováno v:
Scopus-Elsevier
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MM
Autor:
David J. Schurman, R. Lane Smith, M Gupta, B. S. Donlon, N I Hutchinson, Prajnan Das, Dennis R. Carter, M Mohtai, Gary H. Gibbons, John P. Cooke
Publikováno v:
Journal of Orthopaedic Research. 13:824-831
This study tested the effects of fluid-induced shear on high density monolayer cultures of adult articular chondrocytes. Fluid-induced shear (1.6 Pa) was applied by cone viscometer to normal human and bovine articular chondrocytes for periods of 24,
Publikováno v:
The Journal of Immunology. 145:4154-4166
Human IL-1 alpha, IL-1 beta, and TNF-alpha mRNA expression was examined in peripheral blood monocytes (PBM) from normal individuals and in primary synoviocytes isolated from patients with rheumatoid arthritis by Northern blot and in situ hybridizatio
Autor:
J S, Mudgett, N I, Hutchinson, N A, Chartrain, A J, Forsyth, J, McDonnell, I I, Singer, E K, Bayne, J, Flanagan, D, Kawka, C F, Shen, K, Stevens, H, Chen, M, Trumbauer, D M, Visco
Publikováno v:
Arthritis and rheumatism. 41(1)
It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the arthritic paw
Autor:
J R, Calaycay, T M, Kelly, K L, MacNaul, E D, McCauley, H, Qi, S K, Grant, P R, Griffin, T, Klatt, S M, Raju, A K, Nussler, S, Shah, J R, Weidner, H R, Williams, G C, Wolfe, D A, Geller, T R, Billiar, M, MacCoss, R A, Mumford, M J, Tocci, J A, Schmidt, K K, Wong, N I, Hutchinson
Publikováno v:
The Journal of biological chemistry. 271(45)
Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and its native counterpart from cytokine-stimulated primary hepatocytes exhibited similar molec
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(1)
The role of inducible nitric oxide synthase (iNOS) was examined in the hypotension and vascular hyporesponsiveness to norepinephrine (NE) invoked by lipopolysaccharide (LPS) in pentobarbital-anesthetized rats. Saline, dexamethasone (DEX), NG-monometh
Autor:
M W, Lark, K A, MacNaul, S, Donatelli, J, McDonnell, L A, Hoerrner, K A, Stevens, C A, Saphos, E K, Bayne, N I, Hutchinson, V L, Moore
Publikováno v:
The Journal of rheumatology. 21(9)
To study the effects of the intraarticular injection of canine monocyte conditioned medium (cMCM) into dogs on proteoglycan fragment and stromelysin levels in the joint.cMCM was injected intraarticularly into dogs, and the levels of proteoglycan frag
Autor:
F M Torti, D J Schurman, N I Hutchinson, R L Smith, M Mohtai, William G. Stetler-Stevenson, G I Goldberg, Y Tsuji
Publikováno v:
The Journal of clinical investigation. 92(1)
We report here that a 92-kD gelatinolytic metalloproteinase is expressed as protein and mRNA in human osteoarthritic cartilage, but not in normal adult articular cartilage. Western immunoblotting demonstrated that the 92-kD gelatinolytic activity cor
Publikováno v:
Matrix (Stuttgart, Germany). Supplement. 1