Zobrazeno 1 - 10
of 47
pro vyhledávání: '"N I, Obiri"'
Publikováno v:
The Journal of Immunology. 158:756-764
We have reported on the expression and characteristics of IL-13R and have demonstrated that IL-13 competes for IL-4 binding while IL-4 did not compete for the IL-13 binding on some cell types. Based on these observations, and the size of IL-13 and IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03efaf591963ae4a7fac522265ff9721
https://doi.org/10.4049/jimmunol.158.2.756
https://doi.org/10.4049/jimmunol.158.2.756
Autor:
Ira Pastan, SR Husain, Gabriel P. Haas, W Debinski, P Leland, Robert J. Kreitman, N I Obiri, Raj K. Puri
Publikováno v:
Blood. 87:4333-4339
We have previously shown that human renal cell carcinoma (RCC) cells express large numbers of interleukin-13 receptors (IL-13R), a newly described hemopoietic growth factor receptor. To target tumor cells that express IL-13R, we have produced a chime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a49d8dba50597e8474210b165d68d0
https://doi.org/10.1182/blood.v87.10.4333.bloodjournal87104333
https://doi.org/10.1182/blood.v87.10.4333.bloodjournal87104333
Publikováno v:
International journal of molecular medicine. 1(3)
We have recently demonstrated that two different forms of IL-4R exist; classical or alternative. The classical IL-4R is predominantly expressed in hematopoietic cells and consist of IL-4R and IL-2Rgammac (gammac) chains. On the other hand, alternativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bec73f1dac5a1725d4780e38b6a8422
https://pubmed.ncbi.nlm.nih.gov/9852261
https://pubmed.ncbi.nlm.nih.gov/9852261
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(2)
AIDS-associated Kaposi's sarcoma (AIDS-KS), the most common malignant complication of human immunodeficiency virus infection, is characterized by neoplastic proliferation of mesenchymal cells. AIDS-KS cells release and respond to an array of cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9594d50b4bc78b39bd4bd25fda75464
https://pubmed.ncbi.nlm.nih.gov/9815666
https://pubmed.ncbi.nlm.nih.gov/9815666
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(10)
Interleukin-13 (IL-13) is a cytokine produced primarily by activated T lymphocytes. It exerts a variety of effects on different cell types, including monocytes, B lymphocytes, mast cells, and keratinocytes. The effects of IL-13 on target cells are of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::106a4e47d8eb00d62d9220889f7ab4a4
https://pubmed.ncbi.nlm.nih.gov/9816125
https://pubmed.ncbi.nlm.nih.gov/9816125
Publikováno v:
Cellular immunology. 171(1)
We have previously demonstrated that a chimeric protein composed of human IL-4 and Pseudomonas exotoxin, termed IL4-PE4E, is cytotoxic to primary cells derived from human renal cell carcinoma (RCC). To improve the cytotoxicity of IL4-toxins such as I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19c9fc6ddd13c388a2218fb2cab63b7f
https://pubmed.ncbi.nlm.nih.gov/8660841
https://pubmed.ncbi.nlm.nih.gov/8660841
Autor:
R K, Puri, P, Leland, N I, Obiri, S R, Husain, R J, Kreitman, G P, Haas, I, Pastan, W, Debinski
Publikováno v:
Blood. 87(10)
We have previously shown that human renal cell carcinoma (RCC) cells express large numbers of interleukin-13 receptors (IL-13R), a newly described hemopoietic growth factor receptor. To target tumor cells that express IL-13R, we have produced a chime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2eed83ee1130258f3765dd6bfef2ebb
https://pubmed.ncbi.nlm.nih.gov/8639793
https://pubmed.ncbi.nlm.nih.gov/8639793
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(11)
Recently, we have demonstrated that a spectrum of human adenocarcinoma cell lines express binding sites for interleukin 13 (IL-13). These cells are killed by a chimeric protein composed of human (h) IL-13 and a derivative of Pseudomonas exotoxin, PE3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54b75343d4e9ec5e28378d3b11f3fd06
https://pubmed.ncbi.nlm.nih.gov/9815919
https://pubmed.ncbi.nlm.nih.gov/9815919
Publikováno v:
The Journal of biological chemistry. 270(15)
Interleukin 13 (IL-13) shares many biological properties with IL-4, and although the receptor for IL-4 (IL-4R) has been characterized, the expression and structure of IL-13 receptor are unknown. We report here that human renal cell carcinoma (RCC) ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05708c07371cb36102adcf2b423ae5a9
https://pubmed.ncbi.nlm.nih.gov/7721786
https://pubmed.ncbi.nlm.nih.gov/7721786
Publikováno v:
Clinical and experimental immunology. 95(1)
SUMMARY It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors (1L-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51:3011–7). We have also reported that human renal cell ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5269895a388e0677cee76a6ef93f15
https://pubmed.ncbi.nlm.nih.gov/8287600
https://pubmed.ncbi.nlm.nih.gov/8287600