Zobrazeno 1 - 10 of 35 pro vyhledávání: '"N Henriette Uhlenhaut"'
1
Akademický článek
Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
Autor: Kenneth Allen Dyar, Michaël Jean Hubert, Ashfaq Ali Mir, Stefano Ciciliot, Dominik Lutter, Franziska Greulich, Fabiana Quagliarini, Maximilian Kleinert, Katrin Fischer, Thomas Oliver Eichmann, Lauren Emily Wright, Marcia Ivonne Peña Paz, Alberto Casarin, Vanessa Pertegato, Vanina Romanello, Mattia Albiero, Sara Mazzucco, Rosario Rizzuto, Leonardo Salviati, Gianni Biolo, Bert Blaauw, Stefano Schiaffino, N Henriette Uhlenhaut
Publikováno v: PLoS Biology, Vol 16, Iss 8, p e2005886 (2018)
Circadian clocks are fundamental physiological regulators of energy homeostasis, but direct transcriptional targets of the muscle clock machinery are unknown. To understand how the muscle clock directs rhythmic metabolism, we determined genome-wide b
Externí odkaz: https://doaj.org/article/2baff020749c46b7943454ca2b934a95
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2
Akademický článek
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression
Autor: Barbara Höllbacher, Benjamin Strickland, Franziska Greulich, N. Henriette Uhlenhaut, Matthias Heinig
Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1697-1710 (2023)
Glucocorticoids are potent immunosuppressive drugs, but long-term treatment leads to severe side-effects. While there is a commonly accepted model for GR-mediated gene activation, the mechanism behind repression remains elusive. Understanding the mol
Externí odkaz: https://doaj.org/article/1b0bc433c3c3411c8475dceb852ac921
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3
Akademický článek
Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses
Autor: Kathrin Davari, Johannes Lichti, Christian Gallus, Franziska Greulich, N. Henriette Uhlenhaut, Matthias Heinig, Caroline C. Friedel, Elke Glasmacher
Publikováno v: Cell Reports, Vol 19, Iss 3, Pp 643-654 (2017)
Summary: Activation of immune cells results in rapid functional changes, but how such fast changes are accomplished remains enigmatic. By combining time courses of 4sU-seq, RNA-seq, ribosome profiling (RP), and RNA polymerase II (RNA Pol II) ChIP-seq
Externí odkaz: https://doaj.org/article/1ae29280413a4d9daa01607f25d3c719
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4
How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids
Autor: Benjamin A. Strickland, Suhail A. Ansari, Widad Dantoft, N. Henriette Uhlenhaut
Publikováno v: FEBS Letters. 596:2596-2616
Glucocorticoids (GCs) are widely used therapeutic agents to treat a broad range of inflammatory conditions. Their functional effects are elicited by binding to the glucocorticoid receptor (GR), which regulates transcription of distinct gene networks
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c6504c9b6b857266e8e88d763d4a88
https://doi.org/10.1002/1873-3468.14409
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6
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease
Autor: Céline Jouffe, Benjamin D. Weger, Eva Martin, Florian Atger, Meltem Weger, Cédric Gobet, Divya Ramnath, Aline Charpagne, Delphine Morin-Rivron, Elizabeth E. Powell, Matthew J. Sweet, Mojgan Masoodi, N. Henriette Uhlenhaut, Frédéric Gachon
Publikováno v: Jouffe, Céline; Weger, Benjamin D; Martin, Eva; Atger, Florian; Weger, Meltem; Gobet, Cédric; Ramnath, Divya; Charpagne, Aline; Morin-Rivron, Delphine; Powell, Elizabeth E; Sweet, Matthew J; Masoodi, Mojgan; Uhlenhaut, N Henriette; Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 119(10), e2200083119. National Academy of Sciences NAS 10.1073/pnas.2200083119
Proc. Natl. Acad. Sci. U.S.A. 119:e2200083119 (2022)
Significance While increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd824578f563e912c709879f9167c0f8
https://boris.unibe.ch/166573/1/pnas.2200083119.pdf
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7
BRG1 defines a genomic subset of inflammatory genes transcriptionally controlled by the glucocorticoid receptor
Autor: Aikaterini Mechtidou, Franziska Greulich, Benjamin A. Strickland, Céline Jouffe, Filippo M. Cernilogar, Gunnar Schotta, N. Henriette Uhlenhaut
Glucocorticoids (such as Dexamethasone) are commonly used immunomodulatory drugs with potent anti-inflammatory effects, whose mechanisms of action remain incompletely understood. They bind to the Glucocorticoid Receptor (GR), a nuclear hormone recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::256360e4cac9d62f1beafca4c609cff5
https://doi.org/10.1101/2021.12.13.472398
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8
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke
Autor: Meike-Ast Dumbach, Suvra Nath, Yu-Hsuan Chu, Sachin S. Deshpande, N. Henriette Uhlenhaut, Subash C. Malik, Franziska Greulich, Christian Schachtrup, Pasquale Conforti, Jia-di Lin
Publikováno v: Cell Tissue Res., DOI: 10.1007/s00441-021-03539-z (2021)
Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair process. However, molecular mechanisms underlying CNS disease-induced SVZ N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05c6f2bc46b2d8b443663e8d245b689
https://mediatum.ub.tum.de/doc/1705038/document.pdf
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9
Resource
Autor: Michael Wierer, Omar Gonzalez-Garcia, Aikaterini Mechtidou, N. Henriette Uhlenhaut, Franziska Greulich
Publikováno v: Cell Reports
Cell Rep. 34:108742 (2021)
Cell Reports, Vol 34, Iss 6, Pp 108742-(2021)
Summary Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated transcription factor controlling gene expression in numerous cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ed56d449e2d2b71849ead609eb279b
https://pubmed.ncbi.nlm.nih.gov/33567280
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10
Seq-ing answers: Current data integration approaches to uncover mechanisms of transcriptional regulation
Autor: N. Henriette Uhlenhaut, Barbara Höllbacher, Matthias Heinig, Kinga Balazs
Publikováno v: Comp. Struc. Biotech. J. 18, 1330-1341 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1330-1341 (2020)
Advancements in the field of next generation sequencing lead to the generation of ever-more data, with the challenge often being how to combine and reconcile results from different OMICs studies such as genome, epigenome and transcriptome. Here we pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cd6b4ef60e0eb8cd494a7a40356adc
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59447
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