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Formation of human cardiomyocytes is impaired by fibroblastic paracrine signalling: breaking down the mechanisms involved in rebuilding the heart

Autor: A A Ramkisoensing, J Zhang, N Harlaar, D A Pijnappels, A A F De Vries

Publikováno v: European Heart Journal. 43

To date (pre-)clinical effects of inducing cardiac regeneration by cardiac cell therapy have been disappointing. This lack of success may result from the fact that it remains largely unclear how the receiving pathological microenvironment affects thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d54a8aef978588b424f2c6f4bbb685cf
https://doi.org/10.1093/eurheartj/ehac544.2932

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Centres of spiral waves can be detected as phase defect lines in optical voltage mapping data and numerical simulations

Autor: DA Kabus, L Arno, L Leenknegt, N Harlaar, SO Dekker, AV Panfilov, AAF De Vries, DA Pijnappels, H Dierckx

Publikováno v: EP Europace. 24

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): KU Leuven and FWO-Flanders Introduction To study the excitation patterns of spiral waves in two spatial dimensions over time, it is us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b7c11eba1274366c989791efdd9f542
https://doi.org/10.1093/europace/euac053.016

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Formation of human cardiomyocytes is impaired in a fibrotic environment: unravelling human cardiac regeneration

Autor: J Zhang, A A F De Vries, N Harlaar, D A Pijnappels, Arti A. Ramkisoensing

Publikováno v: European Heart Journal. 42

Loss of myocardial tissue remains a leading cause of disease and death, as the adult heart has insufficient regenerative potential. The (pre-)clinical effects of inducing cardiac regeneration by cardiac cell therapy have been disappointing. This lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21ca63d4323fa445a130efd83c1ad0af
https://doi.org/10.1093/eurheartj/ehab724.3271

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Modelling of atrial fibrillation at physiologically relevant scales enabled by massive expansion of native human atrial cardiomyocytes

Autor: M.J. Schalij, Aaf De Vries, R J M Klautz, Daniël A. Pijnappels, T J Van Brakel, N Harlaar, J Zhang, S O Dekker

Publikováno v: EP Europace. 23

Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): LUMC Background Current in vitro models of atrial fibrillation have limited translational potential due to a lack of relevant human physiology or the inabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::384b8330e0dc84d2b70a2725cf25b8bd
https://doi.org/10.1093/europace/euab116.553

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Atrial fibrillation modelling at physiologically relevant scales enabled by massive expansion of native human atrial cardiomyocytes through immortogenetics

Autor: T J Van Brakel, A A F De Vries, R J M Klautz, N Harlaar, Daniël A. Pijnappels, M.J. Schalij, S O Dekker, J Zhang

Publikováno v: European Heart Journal. 41

Background Current in vitro models of atrial fibrillation have limited translational potential due to a lack of relevant human physiology or the inability to reach the high activation frequencies present in human atrial fibrillation. Absence of relev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::749374aed73e77c0d3025407f85d3de7
https://doi.org/10.1093/ehjci/ehaa946.3591

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Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

Autor: Nina Kudryashova, Rupamanjari Majumder, Ronald Wilders, Antoine A.F. de Vries, N Harlaar, Ivan V. Kazbanov, Arie O. Verkerk, Dirk L. Ypey, Daniël A. Pijnappels, Tim De Coster, Balázs Ördög, Alexander V. Panfilov

Publikováno v: eLife, 9. ELIFE SCIENCES PUBLICATIONS LTD
eLife, 9:e55921, 1-23. eLife Sciences Publications
ELIFE
Majumder, R, De Coster, T, Kudryashova, N, Verkerk, A O, Kazbanov, I V, Ördög, B, Harlaar, N, Wilders, R, de Vries, A AF, Ypey, D L, Panfilov, A V & Pijnappels, D A 2020, ' Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating ', eLIFE, vol. 9, e55921 . https://doi.org/10.7554/eLife.55921
eLife
eLife, Vol 9 (2020)

Homeostatic regulation protects organisms against hazardous physiological changes. However, such regulation is limited in certain organs and associated biological processes. For example, the heart fails to self-restore its normal electrical activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffdeae07ee5e5c57bfbda14eafd05bb
https://doi.org/10.7554/elife.55921

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