Zobrazeno 1 - 10
of 43
pro vyhledávání: '"N H Sigal"'
Autor:
G C, Koo, J T, Blake, A, Talento, M, Nguyen, S, Lin, A, Sirotina, K, Shah, K, Mulvany, D, Hora, P, Cunningham, D L, Wunderler, O B, McManus, R, Slaughter, R, Bugianesi, J, Felix, M, Garcia, J, Williamson, G, Kaczorowski, N H, Sigal, M S, Springer, W, Feeney
Publikováno v:
The Journal of Immunology. 158:5120-5128
The voltage activated K+ channel (Kv1.3) has recently been identified as the molecule that sets the resting membrane potential of peripheral human T lymphoid cells. In vitro studies indicate that blockage of Kv1.3 inhibits T cell activation, suggesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9615a864631bb64de5b1681523bfed49
https://doi.org/10.4049/jimmunol.158.11.5120
https://doi.org/10.4049/jimmunol.158.11.5120
Autor:
F J Dumont, N H Sigal
Publikováno v:
Annual Review of Immunology. 10:519-560
CsA, FK-506, and rapamycin are microbial products with potent immunosuppressive properties that result primarily from a selective inhibition of T lymphocyte activation. Although chemically unrelated, CsA and FK-506 affect a similar subset of calcium-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77304123db6ea93c2cd114a40a33ba8c
https://doi.org/10.1146/annurev.iy.10.040192.002511
https://doi.org/10.1146/annurev.iy.10.040192.002511
Publikováno v:
The Journal of Immunology. 144:1418-1424
The structurally related immunosuppressive macrolides FK-506 and rapamycin (RAP) were previously shown to inhibit T cell stimulation through different mechanisms. FK-506 acts similarly to cyclosporin A (CsA) and prevents IL-2 production and IL-2R exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c307bc60c4b83a57803310943b28ffa
https://doi.org/10.4049/jimmunol.144.4.1418
https://doi.org/10.4049/jimmunol.144.4.1418
Publikováno v:
The Journal of Immunology. 144:251-258
FK-506 and the structurally related macrolide rapamycin (RAP) were investigated in comparison with cyclosporin A (CsA) for their immunosuppressive effects on murine T cells. All three agents suppressed the proliferation of splenic T cells triggered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc047e7efdeabe52480934662bffb750
https://doi.org/10.4049/jimmunol.144.1.251
https://doi.org/10.4049/jimmunol.144.1.251
Autor:
A, Talento, M, Nguyen, T, Blake, A, Sirotina, C, Fioravanti, D, Burkholder, R, Gibson, N H, Sigal, M S, Springer, G C, Koo
Publikováno v:
Transplantation. 55(2)
C57BL/6 (B6) thyroid gland transplanted to the left kidney capsule of an allogeneic (BALB/c) host was typically rejected in 14 days. A single administration of 500 micrograms of an antibody to the adhesion molecule, leucocyte function-associated anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b74480a45e82a7df3a29c1d15e2447a9
https://pubmed.ncbi.nlm.nih.gov/7679531
https://pubmed.ncbi.nlm.nih.gov/7679531
Publikováno v:
Transplantation proceedings. 23(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8836c702f3f6dd17149450584ebbca34
https://pubmed.ncbi.nlm.nih.gov/1721256
https://pubmed.ncbi.nlm.nih.gov/1721256
Publikováno v:
Transplantation proceedings. 23(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::400ea1d0ed744d6c843b4bc3aad1f831
https://pubmed.ncbi.nlm.nih.gov/1721300
https://pubmed.ncbi.nlm.nih.gov/1721300
Publikováno v:
Transplantation proceedings. 23(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5916dda6b2ca07b422c6fddaeeec06d9
https://pubmed.ncbi.nlm.nih.gov/1721295
https://pubmed.ncbi.nlm.nih.gov/1721295
Publikováno v:
Transplantation proceedings. 23(2 Suppl 2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6dcfce2b9503b7b926b8f1cca390925
https://pubmed.ncbi.nlm.nih.gov/1712132
https://pubmed.ncbi.nlm.nih.gov/1712132
Publikováno v:
The Journal of biological chemistry. 266(1)
Granzyme B has been purified to homogeneity from the granules of a human cytolytic lymphocyte line, Q31, in an enzymatically active form by a three-step procedure. Q31 granzyme B hydrolyzed Na-t-butyloxycarbonyl-L-alanyl-L-alanyl-L-aspartyl (Boc-Ala-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::600084553f03744389ee6723d963216d
https://pubmed.ncbi.nlm.nih.gov/1985927
https://pubmed.ncbi.nlm.nih.gov/1985927