Zobrazeno 1 - 10 of 63 pro vyhledávání: '"N H, Colburn"'
1
Power frequency magnetic fields do not contribute to transformation of JB6 cells
Autor: N H Colburn, J D Saffer, G Chen, S J Thurston
Publikováno v: Carcinogenesis. 18:1365-1370
The potential for power frequency magnetic fields to enhance neoplastic transformation has been investigated in vitro using promotion-sensitive mouse epidermal JB6 cells. In a soft agar assay, 60-Hz magnetic fields of 0.01, 0.1, 1.0, or 1.1 mT flux d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f8aeb33c41c1631d65f9801075f99c
https://doi.org/10.1093/carcin/18.7.1365
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3
Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation
Autor: T C, Hsu, R, Nair, P, Tulsian, C E, Camalier, G A, Hegamyer, M R, Young, N H, Colburn
Publikováno v: Cancer research. 61(10)
Clonal variants of mouse epidermal JB6 cells that are genetically susceptible (P+) or resistant (P-) to tumor promoter-induced neoplastic transformation exhibit differential activator protein-1 (AP-1) response. Transactivation of AP-1 appears to be n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d61bf20a2bedbed11d386f36177dc4b
https://pubmed.ncbi.nlm.nih.gov/11358840
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4
Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes
Autor: J J, Li, Y, Cao, M R, Young, N H, Colburn
Publikováno v: Molecular carcinogenesis. 29(3)
Neoplastically transformed mouse and human keratinocytes elevate transactivation of both activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB) transcription factors. The present study addresses the question of whether elevated NFkappaB in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31f11a386ab7ae8d13c19b56254ed25d
https://pubmed.ncbi.nlm.nih.gov/11108661
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5
Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells
Autor: M. Young, N. H. Colburn, M. A. Davis, Jodi A. Flaws, K. Collins
Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 53(1)
Selective induction of cell death is a means to remove unwanted cell populations from a tissue or organ. Understanding the signaling events responsible for mediating cell death by cytokines, such as tumor necrosis factor-alpha (TNFalpha) are key to t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8eedcad72224a6d03ce53da9861d41
https://pubmed.ncbi.nlm.nih.gov/10653520
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6
Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene in neoplastic cells
Autor: W D, Pennie, G A, Hegamyer, M R, Young, N H, Colburn
Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(4)
The tissue inhibitor of metalloproteinases-3 (TIMP-3) gene is specifically down-regulated in neoplastic cells of the mouse JB6 progression model, suggesting a role for TIMP-3 inactivation in neoplastic progression. On the basis of 5-azacytidine rever
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cf422cd6aeda9bcdf0b4dfb2e55c5dc
https://pubmed.ncbi.nlm.nih.gov/10319998
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7
Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response
Autor: J J, Li, C, Westergaard, P, Ghosh, N H, Colburn
Publikováno v: Cancer research. 57(16)
Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors might contribute to the process of tumor promoter-induced t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bffe8f69492cc744e4990c982bee9df9
https://pubmed.ncbi.nlm.nih.gov/9270030
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8
A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes
Autor: Z, Dong, H C, Crawford, V, Lavrovsky, D, Taub, R, Watts, L M, Matrisian, N H, Colburn
Publikováno v: Molecular carcinogenesis. 19(3)
We previously reported that induced activator protein-1 (AP-1) transcriptional activity appears to be required for tumor promoter-induced transformation in mouse epidermal JB6 cells. To extend this investigation to a keratinocyte culture model and a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc954e5eaacecfe06468743847a844f7
https://pubmed.ncbi.nlm.nih.gov/9254887
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10
Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element
Autor: J J, Li, Z, Dong, M I, Dawson, N H, Colburn
Publikováno v: Cancer research. 56(3)
Both retinoic acid (RA) treatment and dominant-negative c-Jun mutant expression effectively inhibit phorbol ester-induced AP-1 activity and induced neoplastic transformation in mouse epidermal JB6 cells. However, both reagents also target non-AP-1 mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a12d0b05ef24f9a8edbfea35bbc7d845
https://pubmed.ncbi.nlm.nih.gov/8564958
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