Zobrazeno 1 - 10
of 90
pro vyhledávání: '"N Ghildyal"'
Autor:
Eric Feyfant, Michael F. Gurish, Chifu Huang, Richard L. Stevens, K. Frank Austen, Andrej Sali, N Ghildyal, Hunt Je, Daniel S. Friend, S Stechschulte
Publikováno v:
Journal of Biological Chemistry. 272:29158-29166
Mouse mast cell protease (mMCP) 1, mMCP-2, mMCP-4, and mMCP-5 are members of a family of related serine proteases whose genes reside within an approximately 850 kilobase (kb) complex on chromosome 14 that does not readily undergo crossover events. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae09ca156d6939a25ab31c68df7ae71
https://doi.org/10.1074/jbc.272.46.29158
https://doi.org/10.1074/jbc.272.46.29158
Autor:
N Ghildyal, Daniel S. Friend, Richard L. Stevens, Matthew Webster, Michael F. Gurish, Christopher F. Nicodemus
Publikováno v:
Blood. 90:382-390
Because in humans mast cells and basophils tend to possess nonsegmented and segmented/multi-lobular nuclei, respectively, nuclear morphology has been a major criterion for assessing the lineage of metachromatic cells of hematopoietic origin. Immature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d2f38ea0257edcf331260060d1c69f
https://doi.org/10.1182/blood.v90.1.382
https://doi.org/10.1182/blood.v90.1.382
Publikováno v:
The Journal of Immunology. 158:4373-4380
Mast cells are a heterogeneous family of immune cells that, when activated through their high affinity IgE receptors (Fc epsilonRI), release various granule mediators (e.g., neutral proteases and serglycin proteoglycans) and proinflammatory cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5d0389f29cd0895fd0a24a08be4027
https://doi.org/10.4049/jimmunol.158.9.4373
https://doi.org/10.4049/jimmunol.158.9.4373
Publikováno v:
The Journal of Cell Biology
Whether or not a nontransformed, mature mouse mast cell (MC) or its committed progenitor can change its granule protease phenotype during inflammatory responses, has not been determined. To address this issue, the granule morphology and protease cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d71be3c9cfd19a9eaec33046150db2
https://doi.org/10.1083/jcb.135.1.279
https://doi.org/10.1083/jcb.135.1.279
Autor:
Michael F. Gurish, Daniel S. Friend, K F Austen, N Ghildyal, John F. Penrose, Chifu Huang, Richard L. Stevens, Andrej Sali
Publikováno v:
The Journal of Experimental Medicine
The mouse mast cell protease granule tryptases designated mMCP-6 and mMCP-7 are encoded by highly homologous genes that reside on chromosome 17. Because these proteases are released when mast cells are activated, we sought a basis for distinctive fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4f1b9360949b65b0b82ca74517eae2
https://doi.org/10.1084/jem.184.3.1061
https://doi.org/10.1084/jem.184.3.1061
Packaging of Proteases and Proteoglycans in the Granules of Mast Cells and Other Hematopoietic Cells
Publikováno v:
Journal of Biological Chemistry. 270:19524-19531
Mouse mast cell protease 7 (mMCP-7) is a tryptase stored in the secretory granules of mast cells. At the granule pH of 5.5, mMCP-7 is fully active and is bound to heparin-containing serglycin proteoglycans. to understand the interaction of mMCP-7 wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24857b090975c1b80236de474cc4d31
https://doi.org/10.1074/jbc.270.33.19524
https://doi.org/10.1074/jbc.270.33.19524
Publikováno v:
The Journal of Immunology. 151:4266-4273
Immature, rIL-3-dependent mouse bone marrow-derived mast cells (BMMC) contain high steady-state levels of the mouse mast cell protease (mMCP) 5 transcript but undetectable levels of the mMCP-1, mMCP-2, or mMCP-4 transcripts even though all four of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a438f27ffb702a8dc46762db8fc868cd
https://doi.org/10.4049/jimmunol.151.8.4266
https://doi.org/10.4049/jimmunol.151.8.4266
Publikováno v:
The Journal of Immunology. 151:3206-3214
BALB/cJ mouse mast cells derived by culturing bone marrow progenitor cells in WEHI-3 cell-conditioned medium (BMMCW) do not contain mouse mast cell protease 2 (mMCP-2) mRNA, but these cells can be induced to express this transcript after exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a74d0aaf316c1d89d5777fec7f4f55b
https://doi.org/10.4049/jimmunol.151.6.3206
https://doi.org/10.4049/jimmunol.151.6.3206
Autor:
C F Nicodemus, Richard L. Stevens, Daniel S. Friend, K F Austen, H P McNeil, N Ghildyal, Michael F. Gurish
Publikováno v:
Molecular Biology of the Cell. 3:287a-326a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e4b1cc72dceb8b69c63b0e7e393b79
https://doi.org/10.1091/mbc.3.suppl.287a
https://doi.org/10.1091/mbc.3.suppl.287a
Publikováno v:
Journal of Biological Chemistry. 267:8473-8477
Although transcription of mast cell (MC) secretory granule neutral protease genes has been shown to distinguish MC subclasses in mucosal and serosal environments, the specific cytokines that regulate the expression of these genes have not been determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0cd3322beac09b4b9b6d9c493865c42
https://doi.org/10.1016/s0021-9258(18)42469-6
https://doi.org/10.1016/s0021-9258(18)42469-6