Zobrazeno 1 - 10 of 11 pro vyhledávání: '"N G, Jacobson"'
1
Epstein–Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation
Autor: Micah A. Luftig, Teruhito Yasui, Vishal Soni, N. G. Jacobson, Brian Seed, Ellen Cahir-McFarland, Myung-Soo Kang, Elliott Kieff
Publikováno v: Proceedings of the National Academy of Sciences. 101:141-146
Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1)-induced NF-kappaB activation is important for infected cell survival. LMP1 activates NF-kappaB, in part, by engaging tumor necrosis factor (TNF) receptor-associated factors (TRAFs),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df531c3ca131e9f13f5c8db9de3185aa
https://doi.org/10.1073/pnas.2237183100
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2
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
Autor: Theresa L. Murphy, Domenic Fenoglio, James D. Gorham, Wenjun Ouyang, N. G. Jacobson, Kenneth M. Murphy, Deepta Bhattacharya, William C. Sha
Publikováno v: Proceedings of the National Academy of Sciences. 96:3888-3893
Interleukin 12 (IL-12)-induced T helper 1 (Th1) development requires Stat4 activation. However, antigen-activated Th1 cells can produce interferon gamma (IFN-gamma) independently of IL-12 and Stat4 activation. Thus, in differentiated Th1 cells, facto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2627e08f70f8f571b5c58aefd83b03
https://doi.org/10.1073/pnas.96.7.3888
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3
T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development
Autor: M L Güler, N G Jacobson, U Gubler, K M Murphy
Publikováno v: The Journal of Immunology. 159:1767-1774
In this report, we examined the molecular basis underlying the genetic difference between BALB/c and B10.D2 T cells for T helper phenotype development in vitro. We found a strain-dependent difference in early maintenance of IL-12 responsiveness by T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef2072702ed8bfcfa83048a8a5d967ad
https://doi.org/10.4049/jimmunol.159.4.1767
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4
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
Autor: Susanne J. Szabo, Kenneth M. Murphy, N. G. Jacobson, James E. Darnell, Zhong Zhong, R. M. Weber-Nordt, Robert D. Schreiber
Publikováno v: The Journal of Experimental Medicine
Interleukin 12 (IL-12) initiates the differentiation of naive CD4+ T cells to T helper type 1 (Th1) cells critical for resistance to intracellular pathogens such as Leishmania major. To explore the basis of IL-12 action, we analyzed induction of nucl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33aab24b5632371a38027b873e6c608
https://doi.org/10.1084/jem.181.5.1755
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5
T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases
Autor: Theresa L. Murphy, U. Gubler, James D. Gorham, Kenneth M. Murphy, N. G. Jacobson, Mehmet L. Guler, Susanne J. Szabo, Wenjun Ouyang
Publikováno v: Current Topics in Microbiology and Immunology ISBN: 9783662097113
The effort to understand Th1 and Th2 development has included defining the specific signals that determine phenotype fate upon primary T cell activation by antigen. Numerous parameters of T cell activation appear to influence the overall balance of T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e983323841ef40188355e7382f9bd7e7
https://doi.org/10.1007/978-3-662-09709-0_2
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6
T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development
Autor: M L, Güler, N G, Jacobson, U, Gubler, K M, Murphy
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(4)
In this report, we examined the molecular basis underlying the genetic difference between BALB/c and B10.D2 T cells for T helper phenotype development in vitro. We found a strain-dependent difference in early maintenance of IL-12 responsiveness by T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33af145e638d2f21f855f33e768956fe
https://pubmed.ncbi.nlm.nih.gov/9257839
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9
Regulation of interleukin-12 signalling during T helper phenotype development
Autor: N G, Jacobson, S J, Szabo, M L, Güler, J D, Gorham, K M, Murphy
Publikováno v: Advances in experimental medicine and biology. 409
The experiments described above have allowed us to define the molecular events in IL-12 signalling. Within minutes after IL-12 treatment of responsive cells, Stat1, Stat3, and Stat4 are tyrosine phosphorylated. These molecules form nuclear DNA-bindin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f6ea37e405465ba4ddc729a9cc0f404
https://pubmed.ncbi.nlm.nih.gov/9095224
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10
Regulation of Interleukin-12 Signalling During T Helper Phenotype Development
Autor: James D. Gorham, Mehmet L. Guler, N. G. Jacobson, Kenneth M. Murphy, Susanne J. Szabo
Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461376842
During antigen activation, helper T cells differentiate to stable phenotypes characterized by production of specific cytokines (1,2). The T helper type 1 (Thl) phenotype is characterized by high levels of interferon-γ (IFNγ) and lymphotoxin product
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::605a4117a1482ad1b9237e10d57ff8b5
https://doi.org/10.1007/978-1-4615-5855-2_9
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