Zobrazeno 1 - 10 of 15 pro vyhledávání: '"N G, Ensink"'
1
Administration of BiMAb-Retargeted T Cells in a Rat Hepatic Metastases Colon Tumour Model Results in T-Cell Tumour Infiltration Independent of the Route of Administration
Autor: A. M. M. Eggermont, Gert Jan Fleuren, Ron Koelemij, C.J.H. van de Velde, Peter J. K. Kuppen, N. G. Ensink, Martin Hagenaars
Publikováno v: Scandinavian Journal of Immunology. 53:277-281
In this study, cultured T cells, pre-incubated with the bispecific monoclonal antibody (BiMAb) R73IgG1 × CC52IgG1 were adoptively transferred, via systemic and regional routes, to rats bearing day 10 hepatic metastases of the CC531 adenocarcinoma of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c339c1a1d5fd92ec6e337d7bde9e021
https://doi.org/10.1046/j.1365-3083.2001.00875.x
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2
The Phenotypic Heterogeneity of Human Natural Killer Cells: Presence of at least 48 Different Subsets in the Peripheral Blood
Autor: R. L. P. Van Vlierberghe, Gert Jan Fleuren, Peter J. K. Kuppen, Ulf Nannmark, Bengt Johansson, N. G. Ensink, C.J.H. van de Velde, Liesbeth E. Jonges, Per Albertsson
Publikováno v: Scandinavian Journal of Immunology. 53:103-110
Peripheral blood natural killer (NK) cells are usually defined as a homogeneous cell population. However, NK cells show heterogeneous expression of a diversity of cell surface molecules, which might reflect the diversity of NK-cell functions. Therefo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0cff9349d3fb05451c7f53c988813a4
https://doi.org/10.1046/j.1365-3083.2001.00838.x
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3
Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells
Autor: A.C. Plomp, Peter J. K. Kuppen, Steve J. Cramer, N. G. Ensink, Rob C. Hoeben, M. M. Van Der Eb, Sacha B. Geutskens, Liesbeth E. Jonges
Publikováno v: Gene Therapy. 7:1410-1416
The host-immune response against adenoviruses forms a major obstacle for their use as gene therapy vectors for treatment of genetic defects. None the less, they are the preferred vectors for in vivo gene transfer in experimental gene therapy protocol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e9d5d2e97da081b6bba0090b81ca5d
https://doi.org/10.1038/sj.gt.3301251
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4
Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model
Autor: A. M. M. Eggermont, Gert Jan Fleuren, Martin Hagenaars, E. A. van der Velde, N. G. Ensink, C.J.H. van de Velde, Peter J. K. Kuppen
Publikováno v: Cancer Immunology, Immunotherapy. 48:561-568
Previous experiments in a syngeneic rat liver tumor model using the colon adenocarcinoma CC531 demonstrated that injection of interleukin-2 (IL-2) induced significant antitumor responses. Furthermore, it was found that this treatment strategy was acc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7525b72e9db65ad051aee5888f847b
https://doi.org/10.1007/pl00006674
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5
[Untitled]
Autor: A. M. M. Eggermont, van de Velde Cj, Peter J. K. Kuppen, van Eendenburg Jd, N. G. Ensink, Martin Hagenaars, Ron Koelemij, Gert Jan Fleuren, van Vlierberghe Rl
Publikováno v: Clinical and Experimental Metastasis. 18:281-289
In this paper we describe 4 new monoclonal antibodies to be applied in rat models for cancer. The monoclonal antibodies were obtained by immunizing Balb/c mice with CC531 rat colon adenocarcinoma cells. Hybridomas were produced and 4 were selected fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b6e6fa248316e7f2ddb519d502b79c8
https://doi.org/10.1023/a:1011062002851
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6
Characteristics of tumor infiltration by adoptively transferred and endogenous natural-killer cells in a syngeneic rat model: Implications for the mechanism behind anti-tumor responses
Autor: Peter J. K. Kuppen, Martin Hagenaars, S. Zwaveling, C.J.H. van de Velde, Ulf Nannmark, Marianne Hokland, N. G. Ensink, Gert Jan Fleuren, A. M. M. Eggermont, Per H. Basse
Publikováno v: International Journal of Cancer. 78:783-789
Interleukin-2-activated, cultured NK cells (A-NK) cells were adoptively transferred into a syngeneic rat liver-tumor model. The kinetics of tumor infiltration by NK cells, originating either from adoptively transferred or from endogenous sources, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69d20f2791b7f23347c72d6baa12fcfa
https://doi.org/10.1002/(sici)1097-0215(19981209)78:6<783::aid-ijc17>3.0.co
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7
Dendritic cells in colorectal cancer correlate with other tumor-infiltrating immune cells
Autor: C. J. M. Melief, R.A.E.M. Tollenaar, R. Offringa, N. G. Ensink, C. Janssen Van Rhijn, Hans Morreau, C.J.H. van de Velde, S.H. van der Burg, Maro H. Sandel, A. R. Dadabayev, Anand G. Menon, Peter J. K. Kuppen
Publikováno v: Cancer Immunology Immunother, 53, 978-986
Dendritic cells (DCs) are the most efficient antigen-presenting cells and play a key role in a cellular antitumor immune response. In this study we investigated the exact localization of DCs within colorectal tumors and their relationship to tumor-in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bdff5055a2da9faa73a15dce639feb
http://hdl.handle.net/1887/10728
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8
The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma
Autor: M, Hagenaars, R, Koelemij, N G, Ensink, J D, van Eendenburg, R L, van Vlierberghe, A M, Eggermont, C J, van de Velde, G J, Fleuren, P J, Kuppen
Publikováno v: Clinicalexperimental metastasis. 18(4)
In this paper we describe 4 new monoclonal antibodies to be applied in rat models for cancer. The monoclonal antibodies were obtained by immunizing Balb/c mice with CC531 rat colon adenocarcinoma cells. Hybridomas were produced and 4 were selected fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f02f0c87595915e9483f2904228fafa
https://pubmed.ncbi.nlm.nih.gov/11448057
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9
Administration of BiMAb-retargeted T cells in a rat hepatic metastases colon tumour model results in T-cell tumour infiltration independent of the route of administration
Autor: R, Koelemij, M, Hagenaars, N G, Ensink, A M, Eggermont, C J, Van De Velde, G J, Fleuren, P J, Kuppen
Publikováno v: Scandinavian journal of immunology. 53(3)
In this study, cultured T cells, pre-incubated with the bispecific monoclonal antibody (BiMAb) R73IgG1 x CC52IgG1 were adoptively transferred, via systemic and regional routes, to rats bearing day 10 hepatic metastases of the CC531 adenocarcinoma of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edb10c71364ca47a88f0f58eaf996f7f
https://pubmed.ncbi.nlm.nih.gov/11251885
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10
The microscopic anatomy of experimental rat CC531 colon tumour metastases: consequences for immunotherapy?
Autor: M, Hagenaars, N G, Ensink, P H, Basse, M, Hokland, U, Nannmark, A M, Eggermont, C J, van de Velde, G J, Fleuren, P J, Kuppen
Publikováno v: Clinicalexperimental metastasis. 18(2)
The colon adenocarcinoma cell line CC531 was adopted as a model for immunotherapeutical treatment of experimental colorectal metastases in a syngeneic rat model. We studied the presence and localization of T and natural killer cells, vessels and matr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9eeebebe447e4d057673cb3e7773b99b
https://pubmed.ncbi.nlm.nih.gov/11235995
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