Zobrazeno 1 - 10 of 178 pro vyhledávání: '"N Fairweather"'
1
Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
Autor: Colin Watts, Antonio Lanzavecchia, D G Campbell, P D Simitsek, N Fairweather
Publikováno v: Journal of Experimental Medicine. 181:1957-1963
Bound antibodies can modulate antigen processing but it is not clear to what extent this affects antigen presentation. Here we show that presentation of T cell determinants in tetanus toxin can be either enhanced or suppressed as a direct consequence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f038e95c35ad5e165dd5120db2c7043
https://doi.org/10.1084/jem.181.6.1957
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2
Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis
Autor: D M Yang, N Fairweather, L L Button, W R McMaster, L P Kahl, F Y Liew
Publikováno v: The Journal of Immunology. 145:2281-2285
The gp63 gene of Leishmania major was transformed into the AroA- vaccine strain of Salmonella typhimurium (SL3261). The construct (SL3261-gp63), which stably expresses the gp63 Ag in vitro, was used to immunize CBA mice by the oral route. Spleen cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7d21cd99da6d81fc5728819199fe2cb
https://doi.org/10.4049/jimmunol.145.7.2281
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3
Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin
Autor: A, Knight, J, Carvajal, H, Schneider, C, Coutelle, S, Chamberlain, N, Fairweather
Publikováno v: European journal of biochemistry. 259(3)
Many inherited neurological diseases and cancers could potentially benefit from efficient targeted gene delivery to neurons of the central nervous system. The nontoxic fragment C (HC) of tetanus toxin retains the specific nerve cell binding and trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf9aade8dad9895209a7e5917e705361
https://pubmed.ncbi.nlm.nih.gov/10092862
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4
Akademický článek
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6
Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D beta receptors
Autor: G, Harwood, M, Lockyer, H, Giles, N, Fairweather
Publikováno v: FEBS letters. 377(1)
The genes encoding the rabbit 5HT1D alpha and 5HT1D beta receptors have been cloned. The deduced amino acid sequence of these receptors shows 91-92% amino acid sequence identity with their human homologues, and similar high sequence identity with hom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6330b353800ede40a92dbbf80cfcd3c0
https://pubmed.ncbi.nlm.nih.gov/8543023
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7
Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella
Autor: Raymond J. Pierce, T Ali, A Capron, G Riveau, C M Khan, N Fairweather, Hesta McNeill, B Villarreal-Ramos, R Demarco de Hormaeche, S Chatfield
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 91(23)
A vector has been constructed to allow genetic fusions of guest antigens via a hinge domain to the C terminus of the highly immunogenic C fragment of tetanus toxin. A fusion has been constructed with the gene encoding the protective 28-kDa glutathion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf39b3d926546fbcf18f7237e6390e6
https://pubmed.ncbi.nlm.nih.gov/7972044
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8
Processing and presentation of tetanus toxin by antigen-presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired
Autor: Catherine Barbey, J. M. Tiercy, N. Fairweather, Giampietro Corradin, R. Seger, H. Niemann
Publikováno v: Clinical and experimental immunology. 95(2)
SUMMARY The capacity of peripheral blood lymphocytes (PBL) or Epstein-Barr virus (EBV)-transformed B cell lines from CGD patients to process and present tetanus toxin (tt)-specific epitopes was assessed using various tt preparations and human tt-spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ebb807fb4361fa79b0ab6a5cf45603
https://pubmed.ncbi.nlm.nih.gov/8306496
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9
Prenatal diagnosis for dystrophia myotonica using the polymerase chain reaction
Autor: N. Smith, Johnston Aw, Kevin Kelly, N. Fairweather, Neva E. Haites, C. Clark, T. Brown
Publikováno v: Prenatal diagnosis. 11(7)
The polymerase chain reaction has been used to detect an abundant class of short repeat DNA families of the form (dC-dA)n.(dG-dT)n, known as microsatellites. These units are found throughout the human genome and have been characterized for several lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a176a0af66e0cb02dae927060dcede21
https://pubmed.ncbi.nlm.nih.gov/1754564
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