Výsledky vyhledávání - "N F, Zakirova"

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

Autor: Alexander V. Ivanov, Rustam Ziganshin, Vera L. Tunitskaya, Olga A. Khomich, Birke Bartosch, N. F. Zakirova, Olga A. Smirnova, Marina K. Kukhanova, Sergey N. Kochetkov, Olga N. Ivanova

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity

Hepatitis C virus (HCV) triggers massive production of reactive oxygen species (ROS) and affects expression of genes encoding ROS-scavenging enzymes. Multiple lines of evidence show that levels of ROS production contribute to the development of vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4062052efca2899259b077014df1a399
https://doi.org/10.1155/2019/3196140

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Effects of Siberian fir terpenes extract Abisil on antioxidant activity, autophagy, transcriptome and proteome of human fibroblasts

Autor: Pavel Vorobyov, Alexander G. Brzhozovskiy, Anna V. Kudryavtseva, Faniya Maganova, Yulia S Vershinina, N. F. Zakirova, Alexey Moskalev, Pavel Melnikov, Daria Goliusova, Anastasiya V. Lipatova, Olga Alekseeva, George S. Krasnov

Publikováno v: Aging (Albany NY)

Background: Abisil is an extract of Siberian fir terpenes with antimicrobial and wound healing activities. Previous studies revealed that Abisil has geroprotective, anti-tumorigenic, and anti-angiogenic effects. Abisil decreased the expression of cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11fbfd050c66c9a23f5a5384e71e31
https://pubmed.ncbi.nlm.nih.gov/34428743

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Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response

Autor: Klimova Rr, N. F. Zakirova, A. V. Pronin, Alla A. Kushch, Olga V Payushina, O. V. Masalova, Alexander V. Ivanov, Vyacheslav V Kozlov, Ekaterina D Momotyuk, Nina N Butorina, E. I. Lesnova, A M Ivanova, A.N. Narovlyansky

Publikováno v: Vaccines
Volume 8
Issue 1
Vaccines, Vol 8, Iss 1, p 62 (2020)

Hepatitis C virus (HCV) is one of the major causes of chronic liver disease and leads to cirrhosis and hepatocarcinoma. Despite extensive research, there is still no vaccine against HCV. In order to induce an immune response in DBA/2J mice against HC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaca88c71fa3b002bdd7d502aa4647f2
https://pubmed.ncbi.nlm.nih.gov/32024236

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Inhibitor of polyamine catabolism MDL72.527 restores the sensitivity to doxorubicin of monocytic leukemia Thp-1 cells infected with human cytomegalovirus

Autor: Kirill I. Yurlov, Alla A. Kushch, Svetlana S. Emelianova, Alexander V. Ivanov, Yana Yu Chernoryzh, Sergey N. Kochetkov, Galina R. Vinogradskaya, Larisa E. Zavalyshina, Valery N. Verbenko, N. F. Zakirova, Natalia E. Fedorova

Publikováno v: Biochimie. 158

Leukemic cells from different patients exhibit different sensitivity to anticancer drugs including doxorubicin (DOX). Resistance to chemotherapy decreases efficacy of the treatment and promotes cancer recurrence and metastases. One of the approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f14f3ada76cf427d826aaac366386b
https://pubmed.ncbi.nlm.nih.gov/30578923

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Polyamine Metabolism and Oxidative Protein Folding in the ER as ROS-Producing Systems Neglected in Virology

Autor: Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov, N. F. Zakirova, Olga A. Smirnova

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 4, p 1219 (2018)
International Journal of Molecular Sciences

Reactive oxygen species (ROS) are produced in various cell compartments by an array of enzymes and processes. An excess of ROS production can be hazardous for normal cell functioning, whereas at normal levels, ROS act as vital regulators of many sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c6c0441777974c1fc2f4cac5169c6e
http://www.mdpi.com/1422-0067/19/4/1219

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Lamivudine phosphoramidates. Unexpected products of a well-known reaction

Autor: N. F. Zakirova, Alexander V. Shipitsyn

Publikováno v: Russian Chemical Bulletin. 64:2167-2171

A series of phosphoramidate derivatives of β-L-2´,3´-dideoxy-3´-thiacytidine (lamivudine, 3TC), which are the latent forms of 3TC monophosphate, were synthesized. An optimal synthetic pathway towards these compounds involves synthesis of phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03d5d6062dac196319c38d38e74827a8
https://doi.org/10.1007/s11172-015-1133-x

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Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells

Autor: N. F. Zakirova, V.S. Prassolov, O. V. Masalova, Sergey N. Kochetkov, E. I. Lesnova, Alla A. Kushch, Alexander V. Ivanov, Pavel N. Solyev

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 11, p 2346 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2346
International Journal of Molecular Sciences

The hepatitis C virus (HCV) causes chronic liver disease leading to fibrosis, cirrhosis, and hepatocellular carcinoma. HCV infection triggers various types of cell death which contribute to hepatitis C pathogenesis. However, much is still unknown abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb5f2212bb556306640125ab12a20a
https://www.mdpi.com/1422-0067/18/11/2346

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Acyclovir phosphoramidates as potential anti-HIV drugs

Autor: V.S. Prassolov, A. V. Shipitsyn, M. M. Prokofjeva, Christophe Vanpouille, N. F. Zakirova, Inna L. Karpenko, Sergey N. Kochetkov

Publikováno v: Russian Chemical Bulletin. 63:1192-1196

A number of phosphoramidate derivatives of acyclovir (ACV) were obtained. These compounds revealed themselves as latent forms of acyclovir monophosphate (ACV-MP). The optimized route to the title phosphoramidates involves the synthesis of intermediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40fb51a7acac6eab703ecddf4e3862d1
https://doi.org/10.1007/s11172-014-0571-1

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