Zobrazeno 1 - 5
of 5
pro vyhledávání: '"N F, Farraj"'
Publikováno v:
Biopharmaceuticsdrug disposition. 17(8)
The pharmacokinetics of morphine-6-glucuronide (M6G) after both intravenous dosing and nasal administration were studied in sheep. The nasal formulation consisted of M6G in combination with an absorption promoting delivery system in the form of chito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a181f5cc334e4d54062521a834ab459
https://pubmed.ncbi.nlm.nih.gov/8950049
https://pubmed.ncbi.nlm.nih.gov/8950049
Publikováno v:
Pharmaceutical research. 11(8)
A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d088682e4b4a4af5d8415f0b7b3886a6
https://pubmed.ncbi.nlm.nih.gov/7971722
https://pubmed.ncbi.nlm.nih.gov/7971722
Publikováno v:
Pharmaceutical research. 7(7)
The effects of several prospective absorption enhancers were assessed on the nasal absorption of biosynthetic human growth hormone (hGH) in the rat. These enhancers function by alternative mechanisms that include enzyme inhibition, reduction in mucus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d44dd8d24f2f71d0072bb4b91836a13f
https://pubmed.ncbi.nlm.nih.gov/2395807
https://pubmed.ncbi.nlm.nih.gov/2395807
Publikováno v:
Pharmaceutical research. 5(4)
The stability-pH profile of the gamma-aminobutyric acid prodrug. Progabide, was found to be bell shaped, with maximum stability occurring at pH 6 to 7 with a t1/2 of 126 min. Of its metabolic derivatives, the deamidated product PGA degraded in a simi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f6310347f8a456d85bd4ed34497e816
https://pubmed.ncbi.nlm.nih.gov/3247302
https://pubmed.ncbi.nlm.nih.gov/3247302
Publikováno v:
Pharmaceutical research. 4(1)
A reversed-phase high-performance liquid chromatography (HPLC) assay procedure for Progabide, its active acid metabolite (PGA), and its hydrolytic degradation product (SL79.182) has been developed. This highly specific technique has allowed the simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c6136f0f3c3bc31e6cedf4abf30ca43
https://pubmed.ncbi.nlm.nih.gov/3508525
https://pubmed.ncbi.nlm.nih.gov/3508525