Zobrazeno 1 - 10
of 79
pro vyhledávání: '"N E Hynes"'
The HER family of receptors has an important role in the network of cell signals controlling cell growth and differentiation. Although the activity of the HER receptor is strictly controlled in normal cells, HER2 receptor overexpression plays a pivot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c20d6061c827fb6d433151db8725a0
http://doc.rero.ch/record/303915/files/12-suppl_1-S9.pdf
http://doc.rero.ch/record/303915/files/12-suppl_1-S9.pdf
Autor:
N. E Hynes
Publikováno v:
AACR Education book. 2008:123-130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00017cd968b850e89192641a81ef908
https://doi.org/10.1158/aacr.edb-08-8177
https://doi.org/10.1158/aacr.edb-08-8177
Publikováno v:
British Journal of Cancer
Mitogen-induced mammary cell growth is often accompanied by decreased levels of expression of the p185erbB-2 protein. We have previously reported that oestrogen inhibits erbB-2 mRNA and protein expression in breast cancer cells, while epidermal growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d0c289ae116a20cae5ef544cf160a9
https://doi.org/10.1038/bjc.1994.454
https://doi.org/10.1038/bjc.1994.454
Autor:
Giorgio R. Merlo, N E Hynes
Publikováno v:
International journal of oncology. 5(5)
The murine mammary epithelial cells HC11 were used as a model to examine cooperation between mutated p53 and activated oncogenes for cell growth and transformation. These cells lack wild-type (wt) p53 and their proliferation in monolayer is inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89eb24c82be99b939a004a07cce7365
https://pubmed.ncbi.nlm.nih.gov/21559693
https://pubmed.ncbi.nlm.nih.gov/21559693
Publikováno v:
Molecular Biology of the Cell. 4:849-858
A cell surface proteoglycan, syndecan-1, has been shown to participate in the maintenance of the epithelial cell morphology. A point mutated activated c-Ha-ras gene under the control of the glucocorticoid inducible MMTV-LTR promoter was transfected i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6a67d809a1ca4e8ae168463e85ff9d
https://doi.org/10.1091/mbc.4.8.849
https://doi.org/10.1091/mbc.4.8.849
Publikováno v:
British Journal of Cancer
Four monoclonal antibodies (MAbs) specific for the extracellular domain of the human erbB-2/HER2 protein (FRP5, FSP16, FWP51 and FSP77) have been isolated (Harwerth et al., J. Biol. Chem., 267, 15160-15167, 1992). In this paper we describe the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3fcb986ad9b33ac4ba92e1b2c17e81
http://europepmc.org/articles/PMC1968669
http://europepmc.org/articles/PMC1968669
Autor:
N E Hynes, B. Groner, M.S. Berger, Aron Goldhirsch, William J. Gullick, G. Locher, J. Richner, Richard D. Gelber, Heinz A. Gerber
Publikováno v:
Annals of Oncology. 1:263-268
Summary We investigated the expression of c-erbB-2 protein in two matched groups of breast cancer patients, one with and one without relapse. 37 patients with relapse were compared with 42 patients without recurrence for time of observation, adjuvant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16369ff2f090fed4f4b5f4a9af882802
https://doi.org/10.1093/oxfordjournals.annonc.a057745
https://doi.org/10.1093/oxfordjournals.annonc.a057745
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 12
Summary The molecular mechanisms mediating the anti-proliferative effects of the murine anti-HER2 monoclonal antibody (4D5) were investigated in HER2-overexpr essing human carcinoma cell lines. Treatment with 4D5 resulted in a dramatic accumulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13c924bdd799e87b64f5b143dfce13d
https://pubmed.ncbi.nlm.nih.gov/11521716
https://pubmed.ncbi.nlm.nih.gov/11521716
Autor:
N E, Hynes, H A, Lane
Publikováno v:
Journal of mammary gland biology and neoplasia. 6(1)
The proto-oncogene c-myc encodes a transcription factor which plays a major role in the regulation of normal cellular proliferation and is aberrantly expressed in many breast tumors. In a normal cell Myc expression levels are tightly regulated being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::016a43be5ec8ac2268ba0f9341a85c81
https://pubmed.ncbi.nlm.nih.gov/11467449
https://pubmed.ncbi.nlm.nih.gov/11467449
Publikováno v:
The Journal of biological chemistry. 275(14)
The activity of transcription factors of the Stat family is controlled by phosphorylation of a conserved, carboxyl-terminal tyrosine residue. Tyrosine phosphorylation is essential for Stat dimerization, nuclear translocation, DNA binding, and transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::038356fecc2c6b1023cd01efb6bc9dc0
https://pubmed.ncbi.nlm.nih.gov/10744710
https://pubmed.ncbi.nlm.nih.gov/10744710