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Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor

Autor: D M, Bodine, N E, Seidel, M S, Gale, A W, Nienhuis, D, Orlic

Publikováno v: Blood. 84:1482-1491

Cytokine-mobilized peripheral blood cells have been shown to participate in hematopoietic recovery after bone marrow (BM) transplantation, and are proposed to be useful targets for retrovirus- mediated gene transfer protocols. We treated mice with gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6a792a7714bc0d77ef2a57f1f6d7fa
https://doi.org/10.1182/blood.v84.5.1482.bloodjournal8451482

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In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells

Autor: D M, Bodine, N E, Seidel, K M, Zsebo, D, Orlic

Publikováno v: Blood. 82:445-455

We have examined the effects of administration of stem cell-factor (SCF) on the number and distribution of pluripotent hematopoietic stem cells (PHSC) in normal mice. Using the competitive repopulation assay we found that in vivo administration of SC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49adb09ffd311c69f48c5ff89f71da31
https://doi.org/10.1182/blood.v82.2.445.bloodjournal822445

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Stem cell factor increases colony-forming unit-spleen number in vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as a single factor

Autor: D M, Bodine, D, Orlic, N C, Birkett, N E, Seidel, K M, Zsebo

Publikováno v: Blood. 79:913-919

Hematopoiesis is thought to be modulated by interactions of progenitor cells with hematopoietic growth factors. We have shown that colony- forming units-spleen (CFU-S) and repopulating stem cells require interleukin-3 (IL-3) to survive in vitro, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec65b98e1d9a84651fc5b0822926596c
https://doi.org/10.1182/blood.v79.4.913.bloodjournal794913

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Gentle Chemical Deoxygenation of Hemoglobin Solutions

Autor: Judith Herzfeld, Mark P. Taylor, P. R. Droupadi, N. E. Wang, N. E. Seidel

Publikováno v: Hemoglobin. 14:399-411

Dithionite is often used to deoxygenate aqueous solutions because it reacts readily with oxygen. However, milder reducing agents, that do not ordinarily react readily with oxygen, may do so in the presence of an appropriate redox catalyst. We show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcb6dee00e227966cac1c3b5be1308d
https://doi.org/10.3109/03630269009032000

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Lentivirus-based vectors transduce mouse hematopoietic stem cells with similar efficiency to moloney murine leukemia virus-based vectors

Autor: S, Barrette, J L, Douglas, N E, Seidel, D M, Bodine

Publikováno v: Blood. 96(10)

The low levels of transduction of human hematopoietic stem cells (HSCs) with Moloney murine leukemia virus (MLV) vectors have been an obstacle to gene therapy for hematopoietic diseases. It has been demonstrated that lentivirus vectors are more effic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::785f2a5c4ae705947d98633c31fea96b
https://pubmed.ncbi.nlm.nih.gov/11071632

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Retroviral marking of canine bone marrow: long-term, high-level expression of human interleukin-2 receptor common gamma chain in canine lymphocytes

Autor: T, Whitwam, M E, Haskins, P S, Henthorn, J N, Kraszewski, S E, Kleiman, N E, Seidel, D M, Bodine, J M, Puck

Publikováno v: Blood. 92(5)

Optimization of retroviral gene transfer into hematopoietic cells of the dog will facilitate gene therapy of canine X-linked severe combined immunodeficiency (XSCID) and in turn advance similar efforts to treat human XSCID. Both canine and human XSCI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9e77bb3eafeeb24758d380c10189676
https://pubmed.ncbi.nlm.nih.gov/9716584

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Reversion of monochromosome-mediated suppression of tumorigenicity in malignant melanoma by retroviral transduction

Autor: Y A, Su, M E, Ray, T, Lin, N E, Seidel, D M, Bodine, P S, Meltzer, J M, Trent

Publikováno v: Cancer research. 56(14)

We have developed a general strategy to reverse monochromosome suppression of the malignant phenotypes by retroviral transduction. Our approach involved the introduction of a retroviral expression vector-carried cDNA library into a chromosome 6-suppr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5fffbce51394a312ac664367d95aa42b
https://pubmed.ncbi.nlm.nih.gov/8764103

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Survival and retrovirus infection of murine hematopoietic stem cells in vitro: effects of 5-FU and method of infection

Autor: D M, Bodine, K T, McDonagh, N E, Seidel, A W, Nienhuis

Publikováno v: Experimental hematology. 19(3)

Gene replacement therapy for diseases of the hematopoietic system requires efficient gene transfer to pluripotent hematopoietic stem cells. We have systematically compared a number of protocols for retrovirus-mediated gene transfer into murine repopu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28c67ab21839653412144f0fc422489c
https://pubmed.ncbi.nlm.nih.gov/1704844

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