Výsledky vyhledávání - "N E, Geacintov"

Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots

Autor: T, Buterin, M T, Hess, N, Luneva, N E, Geacintov, S, Amin, H, Kroth, A, Seidel, H, Naegeli

Publikováno v: Cancer research. 60(7)

The fjord region diol-epoxide metabolites of polycyclic aromatic hydrocarbons display stronger tumorigenic activities in rodent studies than comparable bay region diol-epoxides, but the molecular basis for this difference between fjord and bay region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0afbf95e6bcc4e9aeeff4f5421362197
https://pubmed.ncbi.nlm.nih.gov/10766171

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Solution conformation of the (+)-trans-anti-benzo[g]chrysene-dA adduct opposite dT in a DNA duplex

Autor: A K, Suri, B, Mao, S, Amin, N E, Geacintov, D J, Patel

Publikováno v: Journal of molecular biology. 292(2)

The solution structure of the adduct derived from the covalent bonding of the fjord region (+)-(11S, 12R, 13R, 14S) stereoisomer of anti -11,12-dihydroxy-13,14-epoxy-11,12,13, 14-tetrahydrobenzo[g]chrysene, (+)- anti -B[g]CDE, to the exocyclic N(6)am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d454b5c2e262d9ba995b2435bb57805
https://pubmed.ncbi.nlm.nih.gov/10493876

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Photoaddition to DNA by nonintercalated chlorpromazine molecules

Autor: I E, Kochevar, C, Garcia, N E, Geacintov

Publikováno v: Photochemistry and photobiology. 68(5)

Chlorpromazine (CPZ) forms photoadducts with DNA and photosensitizes DNA strand breaks. These reactions may be responsible for the reported photomutagenicity of CPZ and for the well-known cutaneous and ocular phototoxicity associated with this drug.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10c12ec0a221ca0819c746c53f3e929a
https://pubmed.ncbi.nlm.nih.gov/9825699

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The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --A) in a 5'-CGT-3' sequence context

Autor: R, Shukla, T, Liu, N E, Geacintov, E L, Loechler

Publikováno v: Biochemistry. 36(33)

Mutations induced by the (+)-anti diol epoxide of benzo[a]pyrene [(+)-anti-B[a]PDE] were described previously in the supF gene of the Escherichia coli plasmid pUB3 [Rodriguez et al.(1993) Biochemistry, 32, 1759]. (+)-anti-B[a]PDE induced a complex pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bee1daca0b185658bf222b944b17199
https://pubmed.ncbi.nlm.nih.gov/9254624

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Interference of benzo[a]pyrene diol epoxide-deoxyguanosine adducts in a GC box with binding of the transcription factor Sp1

Autor: M C, MacLeod, K L, Powell, V A, Kuzmin, A, Kolbanovskiy, N E, Geacintov

Publikováno v: Molecular carcinogenesis. 16(1)

Previous studies indicated that DNA adducts formed by the carcinogenic diol epoxide 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) can increase the affinity of the transcription factor Sp1 for DNA sequences that are not normall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0326c4a2964de2eff953c67b217bd72
https://pubmed.ncbi.nlm.nih.gov/8634093

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Characterizing the DNA binding modes of a topoisomerase I-poisoning terbenzimidazole: evidence for both intercalative and minor groove binding properties

Autor: D S, Pilch, Z, Xu, Q, Sun, E J, Lavoie, L F, Liu, N E, Geacintov, K J, Breslauer

Publikováno v: Drug design and discovery. 13(3-4)

We have used a broad range of spectroscopic and viscometric techniques to demonstrate that the complexation of a cytotoxic, topoisomerase I-poisoning terbenzimidazole (5PTB) with the poly(dA).poly(dT) duplex exhibits properties characteristic of both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0521378e768272b8ad2c41431bbe9c34
https://pubmed.ncbi.nlm.nih.gov/8874049

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The major, N2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide is capable of inducing G--A and G--C, in addition to G--T, mutations

Autor: S A, Jelinsky, T, Liu, N E, Geacintov, E L, Loechler

Publikováno v: Biochemistry. 34(41)

Mutations induced by the (+)-anti-diol epoxide of benzo[a]pyrene [(+)-anti-B[a]PDE] were collected in the supF gene of the Escherichia coli plasmid pUB3. pUB3 was reacted with (+)-anti-B[a]-PDE and then either (1) transformed immediately into E. coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70ad085c1aea33230f750cd8d89a3031
https://pubmed.ncbi.nlm.nih.gov/7577943

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Characterization of the interaction of the radioprotector 1-methyl-2-[2-(methylthio)-2-piperidinovinyl]quinolinium iodide with supercoiled DNA

Autor: C E, Swenberg, S, Birke, N E, Geacintov

Publikováno v: Radiation research. 127(2)

The interaction of the radioprotector 1-methyl-2-[2-(methylthio)-2-piperidinovinyl]quinolinium iodide (VQ) with linear and supercoiled pIBI30 DNA was studied by flow linear dichroism spectroscopy, equilibrium dialysis, circular dichroism, and UV abso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6f40dc61305420faa28fa6f1ad5e723
https://pubmed.ncbi.nlm.nih.gov/1946996

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Structures of the (+)- and (-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyre ne adducts to guanine-N2 in a duplex dodecamer

Autor: S B, Singh, B E, Hingerty, U C, Singh, J P, Greenberg, N E, Geacintov, S, Broyde

Publikováno v: Cancer research. 51(13)

The structures of the mirror image (+)- and (-)-trans-anti-adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene to guanine N2 have been of great interest because the high biological activity of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc057c7ca5e229176b36a9945b63f41c
https://pubmed.ncbi.nlm.nih.gov/1905197

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Chemical, molecular biology, and genetic techniques for correlating DNA base damage induced by ionizing radiation with biological end points

Autor: N E, Geacintov, C E, Swenberg

Publikováno v: Basic life sciences. 58

The types of DNA base damage induced by ionizing radiation, and also relevant model system investigations on replication and mutagenesis, are reviewed in this paper. Recent advances in DNA synthesis technology and site-directed mutagenesis suggest th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba36a5d5940746effc99fb8fe2413676
https://pubmed.ncbi.nlm.nih.gov/1811481

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