Výsledky vyhledávání

Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1

Autor: J. M. D. Wheeler, Walter F. Bodmer, Neil Mortensen, Hee C. Kim, N E Beck, I. P. M. Tomlinson

Publikováno v: Proceedings of the National Academy of Sciences. 96:10296-10301

Fifteen to twenty-five percent of sporadic colorectal carcinomas are replication error (RER) positive. Because the frequency of mutations in the mismatch repair genes (hMLH1 and hMSH2) is low in these tumors, we have investigated the role of mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05476fe7e96d904f6b8f5ff148551d67
https://doi.org/10.1073/pnas.96.18.10296

Zobrazit plný text záznamu

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells

Autor: H. C. Kim, D. Liu, Mohammad Ilyas, Anastasios J. Karayiannakis, Massimo Pignatelli, Jason A. Efstathiou, J. M. D. Wheeler, Neil Mortensen, Witold Kmiot, Walter F. Bodmer, Raymond J. Playford, N E Beck

Publikováno v: Proceedings of the National Academy of Sciences. 96:2316-2321

Epithelial (E)-cadherin and its associated cytoplasmic proteins (α-, β-, and γ-catenins) are important mediators of epithelial cell–cell adhesion and intracellular signaling. Much evidence exists suggesting a tumor/invasion suppressor role for E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884f6d223594384d98c5e52abde513c0
https://doi.org/10.1073/pnas.96.5.2316

Zobrazit plný text záznamu

Detection of residual disease following breast-conserving surgery

Autor: N. E. Beck, Mike Bradburn, A. C. Vincenti, Richard M. Rainsbury

Publikováno v: British Journal of Surgery. 85:1273-1276

Background Assessment of completeness of tumour excision has become an integral part of breast-conserving surgery, but the accuracy of margin analysis has been questioned. This study compared the results of resection margin analysis with an examinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b240f5b22e4c8d8334d0c30068d55a6
https://doi.org/10.1046/j.1365-2168.1998.00876.x

Zobrazit plný text záznamu

Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled

Autor: N. E. Beck, I. P. M. Tomlinson, T. Homfray, S. V. Hodgson, C. J. Harocopos, W. F. Bodmer

Publikováno v: British Journal of Surgery. 84:233-237

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e987b8e2686421f883aacf80f2ed786
https://doi.org/10.1046/j.1365-2168.1997.02700.x

Zobrazit plný text záznamu

Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled

Autor: Ian Tomlinson, C. J. Harocopos, S. V. Hodgson, N. E. Beck, Walter F. Bodmer, T. Homfray

Publikováno v: British Journal of Surgery. 84:233-237

BACKGROUND: Clinical screening is still the first-line approach to identification of families with hereditary non-polyposis colorectal cancer (HNPCC). The need for uniformity of diagnosis of the syndrome, particularly in multicentre studies, led to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f67db47f7aa1432fd9b5e4bf1b517d
https://doi.org/10.1002/bjs.1800840228

Zobrazit plný text záznamu

Cocaine ‘body packers’

Autor: N. E. Beck, J. E. Hale

Publikováno v: British Journal of Surgery. 80:1513-1516

Intracorporeal drug smuggling, particularly of cocaine, is increasing. The so-called ‘body packers’ present a difficult clinical problem, particularly as no coherent management policy has been formulated. The various methods of diagnosis and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217518c6fb7e1a70db89952ae72fb3cb
https://doi.org/10.1002/bjs.1800801205

Zobrazit plný text záznamu

Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity

Autor: Walter F. Bodmer, I. P. M. Tomlinson, Jill Williamson, C. J. Harocopos, Shirley Hodgson, V. E. Mitchell, N. E. Beck

Publikováno v: International Journal of Colorectal Disease. 12:1-3

A family is reported in which a pair of brothers has developed recurrent venous thromboses, which have been shown in one brother (the proband) to result from a reduced level of tissue plasminogen activator (t-PA) activity. Both brothers have also dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab55b0e5754896b7b21fb0809f40bd1c
https://doi.org/10.1007/s003840050068

Zobrazit plný text záznamu

hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer

Autor: J C, Kim, H C, Kim, S A, Roh, K H, Koo, D H, Lee, C S, Yu, J H, Lee, T W, Kim, H L, Lee, N E, Beck, W F, Bodmer

Publikováno v: Cancer detection and prevention. 25(6)

The pattern of hMLHI and hMSH2 mutations was assessed to identify the genetic correlation between hereditary gastric and colorectal cancers. Four disease groups and their healthy family members were assembled according to the presentation of gastric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4203a13692271e74af38d6d5719776f5
https://pubmed.ncbi.nlm.nih.gov/12132870

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání