Human CCR6+ Memory T-helpers Cells form a Heterogenous Population Including Th17/Th22 and Th17.1 Cells, which Differ in Transcription Factor and Cytokine Expression but all Activate Synovial Fibroblast in an IFNγ-independent Manner

Autor: Jan Piet van Hamburg, Sandra M.J. Paulissen, E Lubberts, Wendy Dankers, Hannah den Braanker, N Davelaar, E. M. Colin

BackgroundChronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial fibroblasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e654380161e32910252ce3bb75e089b
https://doi.org/10.21203/rs.3.rs-221902/v1

THU0047 1,25(OH)2d3 and dexamethasone additively suppress synovial fibroblast activation by ccr6+ th memory cells and enhance the effect of tnf-alpha blockade

Autor: W. Dankers, N. Davelaar, P.S. Asmawidjaja, A.M. Mus, J.M. Hazes, E.M. Colin, E. Lubberts

Publikováno v: THURSDAY, 14 JUNE 2018.

Background Despite improvement in treatment of rheumatoid arthritis (RA) over the past decades, insufficient treatment response and treatment resistance in many patients demonstrate the need to develop new therapeutic strategies. Chronic synovial inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bafb2a553b48f1dd1a0f52f6dd2f7640
https://doi.org/10.1136/annrheumdis-2018-eular.6973

IL-17/Th17 mediated synovial inflammation is IL-22 independent

Autor: Erik Lubberts, Patrick S. Asmawidjaja, Adriana M C Mus, Jan Piet van Hamburg, N Davelaar, Sandra M.J. Paulissen, Odilia B. J. Corneth

Publikováno v: Annals of the Rheumatic Diseases, 72(10), 1700-1707. BMJ Publishing Group
Annals of the rheumatic diseases, 72(10), 1700-1707. BMJ Publishing Group

Background Interleukin (IL)-17A and Th17 cells are critically involved in T cell-mediated synovial inflammation. Besides IL-17A, Th17 cells produce IL-22. Recently, Th22 cells were discovered, which produce IL-22 in the absence of IL-17. However, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3144ca797ec71bd21c6e4f1bce69eb
https://doi.org/10.1136/annrheumdis-2012-202373

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A1.2 Prominent role of pathogenic memory CCR6+ TH17 cell populations in the pathogenesis of ACPA+ patients with rheumatoid arthritis

Autor: N Davelaar, Smj Paulissen, E Lubberts, Wendy Dankers, Jmw Hazes, JP van Hamburg, Php de Jong, Heleen Vroman

Publikováno v: Annals of the Rheumatic Diseases. 74:A1.2-A1

Background and objectives Patients with rheumatoid arthritis (RA) positive for serum anti-citrullinated protein antibodies (ACPAs) have a worse disease course than ACPA- patients. Association of ACPA and HLA-DRB1 suggests the involvement of T cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ee72687c45dbca68b6f8b12a0a7735a
https://doi.org/10.1136/annrheumdis-2015-207259.2