Zobrazeno 1 - 1
of 1
pro vyhledávání: '"N D, McDonnell"'
Autor:
D J, Black, K L, Kunze, L C, Wienkers, B E, Gidal, T L, Seaton, N D, McDonnell, J S, Evans, J E, Bauwens, W F, Trager
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
Consistent with expectations based on human in vitro microsomal experiments, administration of fluconazole (400 mg/day) for 6 days to six human volunteers significantly reduced the cytochrome P450 (P450)-dependent metabolic clearance of the warfarin