Zobrazeno 1 - 9
of 9
pro vyhledávání: '"N D, Eddington"'
Publikováno v:
Medicinal Chemistry. 1:371-381
The enaminones represent potentially useful agents for the clinical treatment in generalized tonic-clonic seizures (Epilepsia, 1993, 34(6), 1141-1145, Biopharm. Drug Disp. 2003, 397-407). A regression analysis was performed to provide a quantitative
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 41:504-516
UNLABELLED Pharmacological intervention in cooperation with physical activity is currently being used in the prevention and treatment of diseases like cardiovascular disease and obesity. Physical activity, both acute and chronic, can cause changes in
Autor:
N, Sirisuth, N D, Eddington
Publikováno v:
Pharmaceutical research. 17(8)
To investigate the ability of an IVIVC developed with a racemate drug as well as each enantiomer in predicting the in vivo enantiomer drug performance.Dissolution of metoprolol extended release tablets with different release characteristics (e.g., fa
Publikováno v:
Biopharmaceuticsdrug disposition. 19(8)
Mivacurium, a non-depolarizing neuromuscular blocking agent, consists of three isomers; trans-trans (57%), cis-trans (36%) and cis-cis (7%). The purpose of this study was to characterize the pharmacokinetics and pharmacodynamics of mivacurium after v
Publikováno v:
Pharmaceutical research. 15(3)
To develop and validate internally an in vitro-in vivo correlation (IVIVC) for a hydrophilic matrix extended release metoprolol tablet.In vitro dissolution of the metoprolol tablets was examined using the following methods: Apparatus II, pH 1.26.8 at
Publikováno v:
Pharmaceutical research. 14(12)
The goal of this study was to determine if the co-administration of esmolol (ES), a short acting cardioselective beta-blocker, significantly alters the pharmacokinetics and/or pharmacodynamics of remifentanil (REMI), an ultra short-acting opioid, in
Autor:
J, Kharidia, N D, Eddington
Publikováno v:
Biopharmaceuticsdrug disposition. 17(2)
Desethylamiodarone (DEA), the major active metabolite of amiodarone (AMD), plays a significant role in the electrophysiological effects observed during AMD therapy. The pharmacokinetics and pharmacodynamics of DEA were studied in rats. Animals were a
Autor:
G H, Kamimori, S I, Lugo, D M, Penetar, A C, Chamberlain, G E, Brunhart, A E, Brunhart, N D, Eddington
Publikováno v:
International journal of clinical pharmacology and therapeutics. 33(3)
Following 49 h of sleep deprivation, 37 healthy males ingested either 2.1, 4.3, or 8.6 mg*kg-1 body weight of caffeine in a randomized double-blind design. Subjects were sleep deprived for additional 12 h and venous blood samples were collected inter
Autor:
G H, Kamimori, R W, Hoyt, N D, Eddington, P M, Young, M J, Durkot, V A, Forte, A E, Brunhart, S, Lugo, A, Cymerman
Publikováno v:
Aviation, space, and environmental medicine. 66(3)
The pharmacokinetics of caffeine and cardio-green (ICG) were examined in four micro swine at sea level (SEA) and following 21 d continuous exposure to 4600 m (ALT) in a hypobaric chamber. Caffeine (84.7 mg) and ICG (10 mg) were administered as separa