Výsledky vyhledávání

The Serological Profile and Molecular Basis of a New Partial D Phenotype, DHR

Autor: M. Williams, R. Mattock, J. W. Jones, Kirstin Finning, D. Voak, N. D. Avent, M.L. Scott

Publikováno v: Vox Sanguinis. 73:252-256

Background and objectives: The Rh D antigen comprises a mosaic of at least 30 epitopes expressed on a 30-kD non-glycosylated Rh D polypeptide. The equivalent Rh CeEe polypeptide expressing the Rh C/c and E/e antigens differs in only 36 of the 417 ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e159760af0450ee9fcccd36eef37256
https://doi.org/10.1159/000461941

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Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone

Autor: Steve Marston, Pia A. J. Huber, M. J. A. Tanner, N. D. Avent, C. S. Redwood

Publikováno v: Europe PubMed Central

A partial clone of caldesmon, coding for the C-terminal 288 amino acids, was isolated from a human fetal liver cDNA library and sequenced. Expression of the clone in Escherichia coli produced a peptide called H1 (M(r) 32,549), which inhibited tropomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dde03c7f0c826bb681044893e89b13
https://doi.org/10.1007/bf00121289

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Using Monoclonal Antibodies and Site Directed Mutagenesis to Map the Epitopes of the Blood Group Rh D Antigen

Autor: M.L. Scott, D. Voak, J. W. Jones, W. Liu, N. D. Avent

Publikováno v: Epitope Recognition Since Landsteiner’s Discovery ISBN: 9783540426516

In 1939 Levine & Stetson [1] investigated a case of a mother, delivered of a stillborn child, having a haemolytic transfusion reaction after being given her husband’s blood. Her serum agglutinated her husband’s red cells and those of 80% of ABO c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::099a9bc2c14f4892679c016e9fbe9a23
https://doi.org/10.1007/978-3-642-56340-9_5

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Prenatal determination of fetal blood group status

Autor: N D, Avent, K M, Finning, P G, Martin, P W, Soothill

Publikováno v: Vox sanguinis. 78

The prenatal determination of fetal blood group status by molecular techniques has been used in the clinical management of alloimmunised pregnancies for seven years, in particular for the definition of fetal Rh D, c and E, K, Fya and Jka status. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8570eb3fb6a224709ebc80e46721f01
https://pubmed.ncbi.nlm.nih.gov/10938946

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The Rh blood group system: a review

Autor: N D, Avent, M E, Reid

Publikováno v: Blood. 95(2)

The Rh blood group system is one of the most polymorphic and immunogenic systems known in humans. In the past decade, intense investigation has yielded considerable knowledge of the molecular background of this system. The genes encoding 2 distinct R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e43c749a1d5faaf073d19597440f16a7
https://pubmed.ncbi.nlm.nih.gov/10627438

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The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in africans with the Rh D-negative blood group phenotype

Autor: B K, Singleton, C A, Green, N D, Avent, P G, Martin, E, Smart, A, Daka, E G, Narter-Olaga, L M, Hawthorne, G, Daniels

Publikováno v: Blood. 95(1)

Antigens of the Rh blood group system are encoded by 2 homologous genes, RHD and RHCE, that produce 2 red cell membrane proteins. The D-negative phenotype is considered to result, almost invariably, from homozygosity for a complete deletion of RHD. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8d16ab61fb4f4c379db714ba5408f55
https://pubmed.ncbi.nlm.nih.gov/10607679

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The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein

Autor: M L, Olsson, J S, Smythe, C, Hansson, J, Poole, G, Mallinson, J, Jones, N D, Avent, G, Daniels

Publikováno v: British journal of haematology. 103(4)

The molecular basis of the three major alleles (Fy(a)/Fy(b)/Fy) of the Duffy (FY) blood group system has recently been established but the Fy(x) phenotype associated with weak expression of the Fy(b) and other FY antigens is poorly understood. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fd3c0bda239d977d92da93f4e05ebac
https://pubmed.ncbi.nlm.nih.gov/9886340

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Effect of 1-beta-D-arabino-furanosyl-cytosine (ara-C) induction of K562 cells on expression of Rh and other blood group active proteins

Autor: E, Wiener, A, Shiels, S N, Wickramasinghe, N D, Avent

Publikováno v: British journal of haematology. 103(1)

K562 cells undergoing differentiation induced by 1-beta-D-arabino-furanosyl-cytosine (ara-C) were examined as a model for studying the biosynthesis and regulation of Rh and other blood group active membrane proteins. Untreated and ara-C-induced K562

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c514887134a96d0d97df3246a23c6df
https://pubmed.ncbi.nlm.nih.gov/9792319

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Molecular genetic methods: principles and feasibility in transfusion medicine

Autor: N. D. Avent

Publikováno v: Vox sanguinis. 74

The scale of the application of molecular biological techniques to modern medicine and research in the biological sciences is vast, and in many instances has captured widespread public appeal. The intention of this review is to summarise the impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a53124d59f5b5aae030ca8f935ffb15
https://pubmed.ncbi.nlm.nih.gov/9704457

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