Zobrazeno 1 - 4
of 4
pro vyhledávání: '"N C, Marchant"'
Autor:
D. Wallace, R.D. Brownsill, A. J. Gray, R. P. Richards, A. R. Taylor, R. M. J. Ings, T. Hughes, M. P. Hiley, J. Williams, C. Lucas, D. B. Campbell, B. H. Gordon, R. Thomas, N. C. Marchant, M. Breen
Publikováno v:
European Journal of Cancer and Clinical Oncology. 26:838-842
The pharmacokinetics and metabolism of intravenously infused 14C-fotemustine (about 100 mg/m2) were examined in 2 cancer patients. Plasma levels of radioactivity increased to a maximum of 4.1 and 5.5 micrograms equivalents per g when the infusion sto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f77092529574c6fe5d32c9e6091350
https://doi.org/10.1016/0277-5379(90)90166-q
https://doi.org/10.1016/0277-5379(90)90166-q
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(9)
Human, rat, and dog phase I and phase II xenobiotic metabolism in precision-cut liver slices and freshly isolated hepatocytes was compared using a range of substrates. Carbamazepine (50 microM) and styrene (2 mM) were used as probes to study the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72e3890c8ad5c839071676c1e1421a12
https://pubmed.ncbi.nlm.nih.gov/8886609
https://pubmed.ncbi.nlm.nih.gov/8886609
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(11)
Testosterone (250 microM), 7-ethoxycoumarin (25 microM), and 1-chloro-2,4-dinitrobenzene (CDNB, 50 microM) were used as substrates to compare phase I and II metabolism in rat precision-cut liver slices and rat hepatocytes. Overall clearance to metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6867d9a90c9b1102364e2cf33b167f68
https://pubmed.ncbi.nlm.nih.gov/8591730
https://pubmed.ncbi.nlm.nih.gov/8591730
Autor:
N. C. Marchant, R. M. J. Ings, J. Williams, D. Wallace, M. Breen, A. R. Taylor, S. Bass, D. B. Campbell
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(11)
1. The comparative metabolism of fenfluramine was investigated in mouse, rat, dog and man following a single oral dose of 14C-(+/-)-fenfluramine hydrochloride (1 mg/kg), and also in rat after eight consecutive 12-h subcutaneous doses (24 mg/kg). 2. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0517845fec805206be155ac560ed9916
https://pubmed.ncbi.nlm.nih.gov/1492418
https://pubmed.ncbi.nlm.nih.gov/1492418