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Akademický článek

Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19

Autor: Milena M. de Souza Andrade, Vinicius N. C. Leal, Iara G. Fernandes, Sarah C. Gozzi-Silva, Danielle R. Beserra, Emily A. Oliveira, Franciane M. E. Teixeira, Tatiana M. Yendo, Maria da Glória T. Sousa, Walcy R. Teodoro, Luana de M. Oliveira, Ricardo W. Alberca, Valéria Aoki, Alberto J. S. Duarte, Maria N. Sato

Publikováno v: Antioxidants, Vol 11, Iss 9, p 1690 (2022)

The formation of microthrombi in lung autopsies indicates the involvement of NETs in the immunopathogenesis of severe COVID-19. Therefore, supplements inhibiting NET formation, in association with drugs with fewer adverse effects, should be a relevan

Externí odkaz: https://doaj.org/article/cb80fe56be5548fdac836f5d8068de7b

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Akademický článek

Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas

Autor: Dhêmerson Souza De Lima, Caio C. B. Bomfim, Vinícius N. C. Leal, Edione C. Reis, Jaíne L. S. Soares, Fernanda P. Fernandes, Eduardo P. Amaral, Flavio V. Loures, Mauricio M. Ogusku, Maria R. D'Imperio Lima, Aya Sadahiro, Alessandra Pontillo

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The interplay between M. tuberculosis (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still remains elusive. The gain-of-function variant rs10754558 in the NLRP3 gene (foun

Externí odkaz: https://doaj.org/article/365d9913d57042b2a2515ba4ec720468

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Severe COVID ‐19 patients show a dysregulation of the NLRP3 inflammasome in circulating neutrophils

Autor: Vinicius N. C. Leal, Milena M. S. Andrade, Franciane M. E. Teixeira, Raylane A. G. Cambui, Mariela E. G. V. Roa, Letícia G. Marra, Suemy M. Yamada, Ricardo W. Alberca, Sarah C. Gozzi‐Silva, Tatiana M. Yendo, Lucas C. Netto, Alberto J. S. Duarte, Maria N. Sato, Alessandra Pontillo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

SARS-CoV-2 triggers inflammasome-dependent release of pro-inflammatory cytokine IL-1β and pyroptosis, therefore contributes to the huge inflammatory response observed in severe COVID-19 patients. Less is known about the engagement of inflammasome in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f228d290c356ef4ebcdfc0c3bdf2462
https://doi.org/10.1111/sji.13247

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A common variant close to the 'tripwire' linker region of NLRP1 contributes to severe COVID-19

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a46e7367dcd4d902e3b778bad8c234
https://doi.org/10.1007/s00011-022-01670-3

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Akademický článek

Vibrio fluvialis attachs to but does not enter Hela cell monolayers

Autor: I. T. Carvalho, V. Magalhães, N. C. Leal, V. Melo, M. Magalhães

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 89, Iss 2, Pp 221-223 (1994)

Considering the possibility that invasiveness could be a neglected factor of virulence in Vibrio fluvialis-linked enteritis, since a dysenteric form of the disease was seen in Bangladesh, we studied 12 Brazilian strains of the organism, six clinical

Externí odkaz: https://doaj.org/article/fef34e38b81449be9e40aae3bbd3aa8a

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[Isolation of pathogenic bacteria in pasteurized type C milk sold in Recife City, Pernambuco, Brazil]

Autor: M R, Padilha, Z F, Fernandes, T C, Leal, N C, Leal, A M, Almeida

Publikováno v: Revista da Sociedade Brasileira de Medicina Tropical. 34(2)

In order to improve information about the microbiological quality of the milk commercially available in the city of Recife, 250 samples of pasteurized type-C milk and 50 samples of raw milk were analyzed for Yersinia enterocolitica and Listeria monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::725bde09df96666cc517be17dfd7215a
https://pubmed.ncbi.nlm.nih.gov/11391438

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[Bacteriologic and serologic studies of an outbreak of plague in the State of Paraíba, Brazil]

Autor: A M, de Almeida, D P, Brasil, N C, Leal, M E, de Melo, R V, do Rêgo, C R, de Almeida

Publikováno v: Memorias do Instituto Oswaldo Cruz. 84(2)

During a plaque outbreak in the Borborema Plateau focus (Paraiba), bacteriological and serological studies were carried out in material from 452 patients (48 positives), 1,938 rodents and other small mammals (75 positives), 4,756 dogs (141 positives)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a864ecdaafc8ba4c1916c4259056a91
https://pubmed.ncbi.nlm.nih.gov/2635752

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