Zobrazeno 1 - 7
of 7
pro vyhledávání: '"N C, Ihle"'
Autor:
M E, Duggan, A M, Naylor-Olsen, J J, Perkins, P S, Anderson, C T, Chang, J J, Cook, R J, Gould, N C, Ihle, G D, Hartman, J J, Lynch
Publikováno v:
Journal of Medicinal Chemistry. 38:3332-3341
The design, synthesis, and pharmacological evaluation of L-734,217, a potent, low-molecular weight, orally active fibrinogen receptor antagonist, is reported. A strategy for producing low-molecular weight inhibitors from the peptide c-[(Ac)CRGDC] A,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495f8387c2303ffd5cd7ce1418f5c538
https://doi.org/10.1021/jm00017a017
https://doi.org/10.1021/jm00017a017
Autor:
N. C. Ihle, Clayton H. Heathcock
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::385e14e1f42c6d1ed198381e4ae8b30a
https://doi.org/10.1002/chin.199332129
https://doi.org/10.1002/chin.199332129
Autor:
M E, Duggan, L T, Duong, J E, Fisher, T G, Hamill, W F, Hoffman, J R, Huff, N C, Ihle, C T, Leu, R M, Nagy, J J, Perkins, S B, Rodan, G, Wesolowski, D B, Whitman, A E, Zartman, G A, Rodan, G D, Hartman
Publikováno v:
Journal of medicinal chemistry. 43(20)
Modification of the potent fibrinogen receptor (alpha(IIb)beta(3)) antagonist 1 generated compounds with high affinity for the vitronectin receptor alpha(v)beta(3). Sequential modification of the basic N-terminus of 1 led to the identification of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27526919826000e62ee0beaa15c67c4c
https://pubmed.ncbi.nlm.nih.gov/11020288
https://pubmed.ncbi.nlm.nih.gov/11020288
Autor:
J J, Cook, M A, Holahan, E A, Lyle, D R, Ramjit, G R, Sitko, M T, Stranieri, R F, Stupienski, A A, Wallace, E L, Hand, J R, Gehret, T, Kothstein, M D, Drag, G Y, McCormick, J J, Perkins, N C, Ihle, M E, Duggan, G D, Hartman, R J, Gould, J J, Lynch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(1)
The antiplatelet activity of L-734,217, a nonpeptide platelet GPIIb/IIIa antagonist, was evaluated in the rat, guinea pig and dog. IC50 for inhibition of in vitro platelet aggregation for these species (agonists: adenosine diphosphate, collagen) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23bba13711a6a24bbae60b757d5d0136
https://pubmed.ncbi.nlm.nih.gov/8764336
https://pubmed.ncbi.nlm.nih.gov/8764336
Autor:
N. C. Ihle, P. A. Wender
Publikováno v:
ChemInform. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27167f2a63a9b8cbd024c68209634b4d
https://doi.org/10.1002/chin.198747175
https://doi.org/10.1002/chin.198747175
Publikováno v:
ChemInform. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1086a3ce87133912e182a227844b5bc0
https://doi.org/10.1002/chin.198849263
https://doi.org/10.1002/chin.198849263
Autor:
P. A. WENDER, N. C. IHLE
Publikováno v:
Chemischer Informationsdienst. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ffb61b76632d04f1df01489f474a065
https://doi.org/10.1002/chin.198648158
https://doi.org/10.1002/chin.198648158