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Akademický článek

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver diseaseResearch in context

Publikováno v: EBioMedicine, Vol 106, Iss , Pp 105232- (2024)

Summary: Background: Abdominal obesity increases the risk for non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: To elucidate the directional cell-type level biological m

Externí odkaz: https://doaj.org/article/a9ca2e74a8164304bf81b6dd03723f19

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Akademický článek

Interplay Between Fatty Acids, Stearoyl-Co-A Desaturase, Mechanistic Target of Rapamycin, and Yes-Associated Protein/Transcriptional Coactivator With PDZ-Binding Motif in Promoting Hepatocellular Carcinoma

Autor: Jihane N. Benhammou, Jim Sinnett-Smith, Joseph R. Pisegna, Enrique J. Rozengurt

Publikováno v: Gastro Hep Advances, Vol 2, Iss 2, Pp 232-241 (2023)

Nonalcoholic fatty liver disease has reached pandemic proportions with one of its most consequential complications being hepatocellular carcinoma (HCC). Nonalcoholic fatty liver disease-related HCC is becoming the leading indication for liver transpl

Externí odkaz: https://doaj.org/article/a62feacb35fb4c84af99f2bc89b7097e

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Akademický článek

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver diseaseResearch in context

Publikováno v: EBioMedicine, Vol 92, Iss , Pp 104620- (2023)

Summary: Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ecto

Externí odkaz: https://doaj.org/article/d790980f12064df98a63142b4ca4e5bb

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Akademický článek

Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival

Autor: Marcus Alvarez, Jihane N. Benhammou, Nicholas Darci-Maher, Samuel W. French, Steven B. Han, Janet S. Sinsheimer, Vatche G. Agopian, Joseph R. Pisegna, Päivi Pajukanta

Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)

Abstract Background Hepatocellular carcinoma (HCC) is a common primary liver cancer with poor overall survival. We hypothesized that there are HCC-associated cell-types that impact patient survival. Methods We combined liver single nucleus (snRNA-seq

Externí odkaz: https://doaj.org/article/b62ad1317f6142be85870e21adbd7bd9

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Akademický článek

Early Impact of MMaT-3 Policy on Liver Transplant Waitlist Outcomes for Hepatocellular Carcinoma

Autor: Anjiya Shaikh, MBBS, Karthik Goli, BS, Nicole E. Rich, MD, Jihane N. Benhammou, MD, PhD, Saira Khaderi, MD, PhD, Ruben Hernaez, MD, PhD, Vatche G. Agopian, MD, John M. Vierling, MD, Donghee Kim, MD, PhD, Aijaz Ahmed, MD, John A. Goss, MD, Abbas Rana, MD, Fasiha Kanwal, MD, MSHS, George Cholankeril, MD, MSECR,

Publikováno v: Transplantation Direct, Vol 8, Iss 5, p e1313 (2022)

Background. To reduce the disparity in access to liver transplant (LT), United Network for Organ Sharing implemented an exception policy in May 2019, which capped hepatocellular carcinoma (HCC) exception score to the median Model for End-Stage Liver

Externí odkaz: https://doaj.org/article/80f4df0ab8ef4f348409278ef721aecc

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Akademický článek

A Telephone and Mail Outreach Program Successfully Increases Uptake of Hepatocellular Carcinoma Surveillance

Autor: Elizabeth S. Aby, Adam C. Winters, Jonathan Lin, Aileen Bui, Jenna Kawamoto, Matthew B. Goetz, Debika Bhattacharya, Joseph R. Pisegna, Folasade P. May, Arpan A. Patel, Jihane N. Benhammou

Publikováno v: Hepatology Communications, Vol 4, Iss 6, Pp 825-833 (2020)

Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide. Society guidelines recommend surveillance with abdominal ultrasound with or without serum alpha‐fetoprotein every 6 months for adults at increased risk of develo

Externí odkaz: https://doaj.org/article/37fb1bacebed462aa8f50b77665e32a8

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Akademický článek

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA

Autor: Jihane N. Benhammou, Arthur Ko, Marcus Alvarez, Minna U. Kaikkonen, Carl Rankin, Kristina M. Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä, Jussi Pihlajamäki, Joseph R. Pisegna, Päivi Pajukanta

Publikováno v: Hepatology Communications, Vol 3, Iss 10, Pp 1356-1372 (2019)

The global obesity epidemic is driving the concomitant rise in nonalcoholic fatty liver disease (NAFLD). To identify new genes involved in central liver functions, we examined liver RNA‐sequence data from 259 patients who underwent morbidly obese b

Externí odkaz: https://doaj.org/article/10c4bc03c6304c95a2394d9a57997ce2

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