Zobrazeno 1 - 10
of 55
pro vyhledávání: '"N B La Thangue"'
Autor:
Udo Oppermann, M Floderer, Benedikt M. Kessler, N B La Thangue, Rebecca Konietzny, Simon M. Carr, E S Hookway, Shonagh Munro
Publikováno v:
Cell Reports
Cell Reports, Vol 19, Iss 11, Pp 2193-2201 (2017)
Cell Reports, Vol 19, Iss 11, Pp 2193-2201 (2017)
Summary The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction
Autor:
Omanma Adighibe, N B La Thangue, K C Gatter, R Leek, Helen Turley, Amanda S. Coutts, Adrian L. Harris, Francesco Pezzella
Publikováno v:
Virchows Archiv. 465:715-722
JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in
E2F activity is negatively regulated by retinoblastoma protein (pRb) through binding to the E2F-1 subunit. Within the E2F heterodimer, DP proteins are E2F partner subunits that allow proper cell cycle progression. In contrast to the other DP proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2b0455d6463d31c00d14ed12d69ca1
https://ora.ox.ac.uk/objects/uuid:a09ecf81-9b71-4b9e-b067-f354c4735a7f
https://ora.ox.ac.uk/objects/uuid:a09ecf81-9b71-4b9e-b067-f354c4735a7f
Autor:
Joanna F. McGouran, Dermot Kerr, Omar Khan, Lindsay Stimson, Amanda S. Coutts, Heidi Olzscha, Geng Liu, Mark R. Middleton, Maria I. New, N B La Thangue, Benedikt M. Kessler
Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1ff7c330fe7f80fca6bb7be29be454
https://doi.org/10.1038/cdd.2013.47
https://doi.org/10.1038/cdd.2013.47
This new 3rd edition of the Oxford Textbook of Oncology is a major piece of scholarly work that details the evolution, evidence base and current best practice in multidisciplinary practice in oncology. Oncology is the largest hospital multi-specialty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1f4bc9f06ca309b15f722884b42afc
https://doi.org/10.1093/med/9780199656103.001.0001
https://doi.org/10.1093/med/9780199656103.001.0001
Publikováno v:
The EMBO Journal. 30:317-327
As a critical target for cyclin-dependent kinases (Cdks), the retinoblastoma tumour suppressor protein (pRb) controls early cell cycle progression. We report here a new type of regulation that influences Cdk recognition and phosphorylation of substra
Publikováno v:
Oncogene. 29:2357-2367
The pRb tumour suppressor protein has a central role in coordinating early cell cycle progression. An important level of control imposed on pRb occurs through post-translational modification, for example, phosphorylation. We describe here a new level
Autor:
David J. Kerr, Catherine Hildyard, Graham P. Collins, K. Myers, Mark R. Middleton, Toby A. Eyre, Lisa K. Folkes, Michael R.L. Stratford, N B La Thangue
Publikováno v:
Hematological Oncology. 35:408-408
Autor:
Zalmas L-P., Simon M. Carr, Shonagh Munro, Udo Oppermann, Catrine Johansson, N B La Thangue, T. Krojer, Mark T. Bedford, Oleg Fedorov, Cari A. Sagum
The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912d0fb0a08ce3ecec3db97276ad1bb0
https://europepmc.org/articles/PMC4128150/
https://europepmc.org/articles/PMC4128150/
Autor:
Michael R.L. Stratford, N B La Thangue, Amanda S. Coutts, Benedikt M. Kessler, Joanna F. McGouran, Sandra Maniam
Publikováno v:
Cell death and differentiation. 22(1)
Metabolic reprogramming is a hallmark of cancer cells. Strap (stress-responsive activator of p300) is a novel TPR motif OB-fold protein that contributes to p53 transcriptional activation. We show here that, in addition to its established transcriptio