Zobrazeno 1 - 10
of 14
pro vyhledávání: '"N B Ghazal"'
Publikováno v:
The Journal of Organic Chemistry. 61:5813-5817
Condensation of racemic keto-ester 2 and 1.1 equiv of (R)-(−)-phenylglycinol in toluene with azeotropic removal of water and methanol gave rise to a tetracyclic lactam in greater than 90% yield. Examination of the crude reaction product by 1H and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c9ed3cad49e4724d1d8e4d8e8ee8166
https://doi.org/10.1021/jo960185l
https://doi.org/10.1021/jo960185l
Autor:
N. B. Ghazal, Robert L. Hoffman, Michael D. Ennis, C. G. Chidester, Chiu-Hong Lin, G. Phillips, Susanne R. Haadsma-Svensson
Publikováno v:
Journal of Heterocyclic Chemistry. 31:129-139
An efficient synthesis of the potent and orally active 5-HT 1A agonists, (R)-(+)- and (S)-(-)-1-formyl-6,7,8,9-tetrahydro-N,N-dipropyl-3H-benz[e]indol-8-amines 1a and 1b, is described. This synthesis was accomplished in twelve steps from commercially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a110d46c9abdbf752b2be4b7d995a71
https://doi.org/10.1002/jhet.5570310123
https://doi.org/10.1002/jhet.5570310123
Autor:
N. B. Ghazal, Michael D. Ennis, Robert L. Hoffman, C. G. Chidester, Chiu-Hong Lin, Susanne R. Haadsma-Svensson, G. Phillips
Publikováno v:
ChemInform. 26
An efficient synthesis of the potent and orally active 5-HT 1A agonists, (R)-(+)- and (S)-(-)-1-formyl-6,7,8,9-tetrahydro-N,N-dipropyl-3H-benz[e]indol-8-amines 1a and 1b, is described. This synthesis was accomplished in twelve steps from commercially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac14280c774c22e44e42a6c9391cb66
https://doi.org/10.1002/chin.199511144
https://doi.org/10.1002/chin.199511144
Autor:
H. Wikstroem, Robert Louis Hoffman, Kjell A. Svensson, N. B. Ghazal, M. W. Smith, Chiu-Hong Lin, Susanne R. Haadsma-Svensson, P. Stjernloef, Michael D. Ennis
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d38eb940f3e44161d87c81bb1f0019e
https://doi.org/10.1002/chin.199542133
https://doi.org/10.1002/chin.199542133
Autor:
Lars O. Hansson, Michael D. Ennis, P. Stjernloef, Arvid Carlsson, N. B. Ghazal, M. W. Smith, S. Sundell, Kjell A. Svensson, H. Wikstroem, Robert Louis Hoffman
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8f719e697c01ab1184a3abf87c6c42
https://doi.org/10.1002/chin.199542132
https://doi.org/10.1002/chin.199542132
Autor:
P. de Boer, N. B. Ghazal, T. A. Barf, K. Svensson, M. W. Smith, H. Wikstroem, S. J. Peroutka, M. D. Ennis, J. C. Mcguire
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9f70025a3a9f74755462f56d7da6deb
https://doi.org/10.1002/chin.199711099
https://doi.org/10.1002/chin.199711099
Publikováno v:
ChemInform. 28
Condensation of racemic keto-ester 2 and 1.1 equiv of (R)-(−)-phenylglycinol in toluene with azeotropic removal of water and methanol gave rise to a tetracyclic lactam in greater than 90% yield. Examination of the crude reaction product by 1H and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aafa47ab665e1d32a2e34b1acbc8db7
https://doi.org/10.1002/chin.199706117
https://doi.org/10.1002/chin.199706117
Autor:
M. S. Holm, Michael D. Burdick, Robert G. Schaub, Michael K. Bach, Ayako Yamashita, A. Toy, John R. Brashler, N. B. Ghazal, Gordon J. White
Publikováno v:
Journal of Medicinal Chemistry. 33:775-781
A series of substituted 1,4-dihydronaphthoquinones, hydroindoloquinones, benzofuran-4,7-dihydroquinones, and benzothiophene-4,7-dihydroquinones were synthesized and evaluated for inhibitory activity against 5-lipoxygenase. These compounds were found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb43c886bffe71151bc4255910bf8be
https://doi.org/10.1021/jm00164a050
https://doi.org/10.1021/jm00164a050
Autor:
R Huff, R TenBrink, Robert L Hoffman, N R Higdon, N B Ghazal, C L Bergh, R B McCall, Michael D. Ennis, C L Chio, E Hall, K Meisheri
Publikováno v:
Cephalalgia : an international journal of headache. 22(10)
The present study describes the preclinical pharmacology of a highly selective 5-HT1Dreceptor agonist PNU-142633. PNU-142633 binds with a Ki of 6 nM at the human 5-HT1Dreceptor and a Ki of > 18 000 nM at the human 5-HT1B receptor. The intrinsic activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b671ef13fee7f8a28a64c549725f0bfd
https://pubmed.ncbi.nlm.nih.gov/12485205
https://pubmed.ncbi.nlm.nih.gov/12485205
Autor:
Michael D. Burdick, Ayako Yamashita, Gordon J. White, M. S. Holm, Robert G. Schaub, N. B. Ghazal, A. Toy, John R. Brashler, Michael K. Bach
Publikováno v:
ChemInform. 21
A series of substituted 1,4-dihydronaphthoquinones, hydroindoloquinones, benzofuran-4,7-dihydroquinones, and benzothiophene-4,7-dihydroquinones were synthesized and evaluated for inhibitory activity against 5-lipoxygenase. These compounds were found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63feaacf0e1d9a73395d8ca272797db1
https://doi.org/10.1002/chin.199025147
https://doi.org/10.1002/chin.199025147