Zobrazeno 1 - 10
of 11
pro vyhledávání: '"N B Dass"'
Autor:
V J North-Laidler, B. R. Tuladhar, R Morrow, Anna K. Bassil, Gareth J. Sanger, N B Dass, E. Aziz
Publikováno v:
British Journal of Pharmacology. 150:502-508
Background and purpose: The neuromedin U (NMU) receptors, NMU1 and NMU2, are expressed in the gut but their functions are unclear. This study explores the role of NMU in gastrointestinal motility. Experimental approach: The effects of NMU were examin
Autor:
Anna K. Bassil, F P Maurio, C M Taylor, Gareth J. Sanger, N B Dass, C W Crumbley, Gary B.T. Moore, A K John, W R Shehee
Publikováno v:
Neurogastroenterology & Motility. 19:66-74
The G protein-coupled receptors, GPR41 and GPR43, are activated by short-chain fatty acids (SCFAs), with distinct rank order potencies. This study investigated the possibility that SCFAs modulate intestinal motility via these receptors. Luminal SCFA
Autor:
Olutunde Lalude, Shanmugam Vivekanandan, Gareth J. Sanger, N B Dass, Anna K. Bassil, Selim Cellek, A K John, Emma M. Jarvie, Ramkumar Thangiah
Publikováno v:
Neurogastroenterology and Motility. 18:853-861
Previous studies have demonstrated mixed inhibitory and facilitatory effects of 5-hydroxytryptamine-4 (5-HT(4)) receptor agonists on electrical field stimulation (EFS)-induced responses in human isolated colon. Here we report three types of responses
Publikováno v:
British Journal of Pharmacology. 140:948-954
Following identification of the human motilin receptor, we isolated the rabbit orthologue by PCR amplification and found this to be 85% identical to the open reading frame of the human receptor. The protein encoded was 84% identical to the human poly
Autor:
G.J Hervieu, M Morgan, N B Dass, Anna K. Bassil, M. L. Munonyara, S Osbourne, Gareth J. Sanger, S Corcoran
Publikováno v:
Neuroscience. 120:443-453
The peptide hormone ghrelin is known to be present within stomach and, to a lesser extent, elsewhere in gut. Although reports suggest that gastric function may be modulated by ghrelin acting via the vagus nerve, the gastrointestinal distribution and
Publikováno v:
Autonomic and Autacoid Pharmacology. 22:147-154
1. GABA(B1) receptor subunit knockout mice were generated and the effects of the GABA(B) receptor agonist, baclofen, were evaluated within the peripheral nervous system (PNS) of wildtype (+/+), heterozygote (+/-) and knockout (-/-) animals. For this
Publikováno v:
British journal of pharmacology. 150(4)
The neuromedin U (NMU) receptors, NMU1 and NMU2, are expressed in the gut but their functions are unclear. This study explores the role of NMU in gastrointestinal motility.The effects of NMU were examined in the forestomach and colon isolated from NM
Publikováno v:
European journal of pharmacology. 544(1-3)
Ghrelin increases electrically evoked, neuronally mediated contractions of rat isolated forestomach, a prokinetic-like activity. Since the nerve type sensitive to ghrelin is unclear, we examined the activity of ghrelin in the presence of antagonists
Publikováno v:
European journal of pharmacology. 524(1-3)
The ability of agents described as gastrointestinal prokinetics (prokineticin-2, [Nle(13)]-motilin, ghrelin), to modulate nerve-mediated contractions of mouse isolated stomach and colon was determined and compared with the prokinetic and 5-HT(4) rece
Publikováno v:
British journal of pharmacology. 140(5)
Following identification of the human motilin receptor, we isolated the rabbit orthologue by PCR amplification and found this to be 85% identical to the open reading frame of the human receptor. The protein encoded was 84% identical to the human poly