Zobrazeno 1 - 10
of 73
pro vyhledávání: '"N B, Standen"'
Publikováno v:
Biochemical and Biophysical Research Communications. 374:742-746
Since, in addition to its growth-promoting actions, insulin-like growth factor-I (IGF-I) has rapid vasoactive actions, we investigated the effects of IGF-I on whole-cell ATP-sensitive K(+) (K(ATP)) currents of rat mesenteric arterial smooth muscle ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ecaf722b6b1dbd74ad25c0af1c4772
https://doi.org/10.1016/j.bbrc.2008.07.100
https://doi.org/10.1016/j.bbrc.2008.07.100
Publikováno v:
Cardiovascular Research. 76:61-70
The vasoconstrictor angiotensin II (Ang II) acts at G(q/11)-coupled receptors to suppress ATP-sensitive potassium (K(ATP)) channel activity via activation of protein kinase C (PKC). The aim of this study was to determine the PKC isoforms involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f922748105498f0dafa57062e376ac4
https://doi.org/10.1016/j.cardiores.2007.05.020
https://doi.org/10.1016/j.cardiores.2007.05.020
Autor:
N. B. Standen, John S. Mitcheson, Sarah L. Cockerill, Gary B. Willars, Ignacio Torrecilla, Andrew B. Tobin
Publikováno v:
The Journal of Physiology. 581:479-493
The human ether-a-go-go related gene (hERG) potassium channel is expressed in a variety of tissues including the heart, neurons and some cancer cells. hERG channels are modulated by several intracellular signalling pathways and these provide importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf50cd1482e6c949fb4e5577a031855f
https://doi.org/10.1113/jphysiol.2006.123414
https://doi.org/10.1113/jphysiol.2006.123414
Publikováno v:
The Journal of Physiology. 575:833-844
Potassium channels contribute to the regulation of contractile tone in vascular smooth muscle, and so to blood vessel diameter, blood flow and blood pressure. Tone is controlled by the intracellular concentration of Ca2+ by way of Ca2+–calmodulin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97aa71fcd1b15ed7b4c540b82fe809f5
https://doi.org/10.1113/jphysiol.2006.114009
https://doi.org/10.1113/jphysiol.2006.114009
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 54:173-182
Introduction Potential-sensitive dyes have primarily been used to optically record action potentials (APs) in whole heart tissue. Using these dyes to record drug-induced changes in AP morphology of isolated cardiac myocytes could provide an opportuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebb7cea9657d97e96ffdf5075a99d63
https://doi.org/10.1016/j.vascn.2006.02.013
https://doi.org/10.1016/j.vascn.2006.02.013
Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K channels during metabolic stress
Publikováno v:
Journal of Molecular and Cellular Cardiology. 39:637-646
ATP-sensitive K + (K A T P ) channels are involved in ischemic cardioprotection induced by preconditioning (IPC), though the relative role of sarcolemmal (sK A T P ) and mitochondrial (mitoK A T P ) channels remains controversial. The sK A T P -selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9304496b11fce24041a5283455381533
https://doi.org/10.1016/j.yjmcc.2005.06.017
https://doi.org/10.1016/j.yjmcc.2005.06.017
Publikováno v:
Circulation Research. 95:1012-1018
Arterial ATP-sensitive K + (K ATP ) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters that alter smooth muscle contractility and so blood flow. Clinically, these channels form the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee85a89dc8512fb5dd59177362ecb0c4
https://doi.org/10.1161/01.res.0000148634.47095.ab
https://doi.org/10.1161/01.res.0000148634.47095.ab
Autor:
Diane Hudman, N. B. Standen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 37:579-591
The protective effects of the PKC activator Phorbol 12-myristate 13-acetate (PMA) were investigated in electrically field stimulated (EFS) rat isolated ventricular myocytes following 7 min of metabolic inhibition induced by cyanide, iodoacetic acid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6337005aebec94e22363512cd859a256
https://doi.org/10.1016/j.yjmcc.2004.05.019
https://doi.org/10.1016/j.yjmcc.2004.05.019
Autor:
Noel W. Davies, Robert I. Norman, Richard D. Rainbow, N. B. Standen, Diane Hudman, David Lodwick
Publikováno v:
The Journal of Physiology. 557:785-794
C-terminal fragments of the sulphonylurea receptor SUR2A can alter the functional expression of cloned ATP-sensitive K(+) channels (K(ATP)). To investigate the protective role of K(ATP) channels during metabolic stress we transfected SUR2A fragments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea29a5857d6d59cd97c38f1a51871d7d
https://doi.org/10.1113/jphysiol.2004.061655
https://doi.org/10.1113/jphysiol.2004.061655
Publikováno v:
Journal of Membrane Biology. 192:141-148
Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels are sensitive to both voltage and internal [Ca(2+)] and are found in many tissues. Their physiological roles range from causing relaxation of smooth muscle to regulating the frequency of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62818ffee29c0c3cc96e158df341f8a
https://doi.org/10.1007/s00232-002-1070-0
https://doi.org/10.1007/s00232-002-1070-0