Zobrazeno 1 - 10
of 94
pro vyhledávání: '"N Adrian Leu"'
Autor:
Yongjuan Guan, Hongyan Gao, N Adrian Leu, Anastassios Vourekas, Panagiotis Alexiou, Manolis Maragkakis, Zhenlong Kang, Zissimos Mourelatos, Guanxiang Liang, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010566 (2023)
Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements, control of transp
Externí odkaz:
https://doaj.org/article/6fb3ccb1c174425a95ff36753cfe0893
Autor:
Alan T Tang, David W Buchholz, Katherine M Szigety, Brian Imbiakha, Siqi Gao, Maxwell Frankfurter, Min Wang, Jisheng Yang, Peter Hewins, Patricia Mericko-Ishizuka, N Adrian Leu, Stephanie Sterling, Isaac A Monreal, Julie Sahler, Avery August, Xuming Zhu, Kellie A Jurado, Mingang Xu, Edward E Morrisey, Sarah E Millar, Hector C Aguilar, Mark L Kahn
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001989 (2023)
Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus Disease 2019 (COVID-19) pathogenesis is indisputable, there remains significan
Externí odkaz:
https://doaj.org/article/1b38b8dd914148c090723f094f8d38fc
Autor:
Seth D Kasowitz, Jun Ma, Stephen J Anderson, N Adrian Leu, Yang Xu, Brian D Gregory, Richard M Schultz, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007412 (2018)
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs. Here we show that the nuclear m6A reader YTHDC1 is essential for embryo viabili
Externí odkaz:
https://doaj.org/article/96984f59b2b140f0a301bad88184fee4
Autor:
Sabyasachi Bhattacharya, Kanstantsin V Katlinski, Maximilian Reichert, Shigetsugu Takano, Angela Brice, Bin Zhao, Qiujing Yu, Hui Zheng, Christopher J Carbone, Yuliya V Katlinskaya, N Adrian Leu, Kelly A McCorkell, Satish Srinivasan, Melanie Girondo, Hallgeir Rui, Michael J May, Narayan G Avadhani, Anil K Rustgi, Serge Y Fuchs
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 384-397 (2014)
Abstract Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitinat
Externí odkaz:
https://doaj.org/article/023f6fcb1025437991143748532942e5
Autor:
Mengcheng Luo, Jian Zhou, N Adrian Leu, Carla M Abreu, Jianle Wang, Montserrat C Anguera, Dirk G de Rooij, Maria Jasin, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004954 (2015)
Polycomb group proteins mediate transcriptional silencing in diverse developmental processes. Sex chromosomes undergo chromosome-wide transcription silencing during male meiosis. Here we report that mouse SCML2 (Sex comb on midleg-like 2), an X chrom
Externí odkaz:
https://doaj.org/article/621c5b5e66ee41edb4a88fdf68d700cc
Autor:
Motomasa Ihara, Mirella L Meyer-Ficca, N Adrian Leu, Shilpa Rao, Fan Li, Brian D Gregory, Irina A Zalenskaya, Richard M Schultz, Ralph G Meyer
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004317 (2014)
To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regu
Externí odkaz:
https://doaj.org/article/2f3ea3d4be4645059c9d472db12c662c
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89471 (2014)
Tudor domain containing (Tdrd) proteins that are expressed in germ cells are divided into two groups. One group, consisting of TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing, while the other group including
Externí odkaz:
https://doaj.org/article/44b6621a458941e0ab4e9c70bd0fe75b
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002516 (2012)
During spermiogenesis, haploid round spermatids undergo dramatic cell differentiation and morphogenesis to give rise to mature spermatozoa for fertilization, including nuclear elongation, chromatin remodeling, acrosome formation, and development of f
Externí odkaz:
https://doaj.org/article/e2164d1f128443dea69297c17e77a783
Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1.
Autor:
Juan Qian, Hui Zheng, Wei-Chun Huangfu, Jianghuai Liu, Christopher J Carbone, N Adrian Leu, Darren P Baker, Serge Y Fuchs
Publikováno v:
PLoS Pathogens, Vol 7, Iss 6, p e1002065 (2011)
An ability to sense pathogens by a number of specialized cell types including the dendritic cells plays a central role in host's defenses. Activation of these cells through the stimulation of the pathogen-recognition receptors induces the production
Externí odkaz:
https://doaj.org/article/7db3ebbeb206433abdb4e4c8885684e6
Autor:
Fang Yang, Yong Cheng, Jee Young An, Yong Tae Kwon, Sigrid Eckardt, N Adrian Leu, K John McLaughlin, Peijing Jeremy Wang
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14017 (2010)
Ubiquitin E3 ligases target their substrates for ubiquitination, leading to proteasome-mediated degradation or altered biochemical properties. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule proteolytic pathway, recognizes pro
Externí odkaz:
https://doaj.org/article/025f8409d680445e8bfcce826cc66b42