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Taking the Leap: Runx1 in the Formation of Blood from Endothelium

Autor: J, Tober, M W, Maijenburg, N A, Speck

Publikováno v: Current topics in developmental biology. 118

Blood cell formation in the embryo occurs from multiple anatomic sites and results in the production of hematopoietic stem and progenitor cells that appear in overlapping waves. The transcription factor Runx1 is involved in a dramatic step of this pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05bb8b09a1f8870482422f13151aa26a
https://pubmed.ncbi.nlm.nih.gov/27137656

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Overexpression of Core-Binding Factor α (CBFα) Reverses Cellular Transformation by the CBFβ-Smooth Muscle Myosin Heavy Chain Chimeric Oncoprotein

Autor: Paul P. Liu, Amitav Hajra, Frank H. Collins, N. A. Speck

Publikováno v: Molecular and Cellular Biology. 15:4980-4989

A fusion between the transcription factor core-binding factor beta (CBF beta; also known as PEBP2 beta) and the tail region of smooth muscle myosin heavy chain (SMMHC) is generated by an inversion of chromosome 16 [inv(16) (p13q22)] associated with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcc26610d78c13fff75d3529e6ff195
https://doi.org/10.1128/mcb.15.9.4980

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

Autor: S Wang, Q Wang, B E Crute, I N Melnikova, S R Keller, N A Speck

Publikováno v: Molecular and Cellular Biology. 13:3324-3339

Moloney murine leukemia virus causes thymic leukemias when injected into newborn mice. A major determinant of the thymic disease specificity of Moloney virus genetically maps to the conserved viral core motif in the Moloney virus enhancer. Point muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7a84984cc85725a554c0c38a8f756c6
https://doi.org/10.1128/mcb.13.6.3324

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The role of viral enhancer 'core' motif-related sequences in regulating T cell receptor-gamma and -delta gene expression

Autor: Y H Hsiang, D Spencer, S Wang, N A Speck, D H Raulet

Publikováno v: The Journal of Immunology. 150:3905-3916

T cells express clonally distributed alpha beta or gamma delta Ag receptor heterodimers. Transcriptional enhancers for the genes of all four subunits are active in both gamma delta and alpha beta T cells, but are less active or inactive in other cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b76aee7385235cf12776f7c03a37a8f2
https://doi.org/10.4049/jimmunol.150.9.3905

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Grade 3 vulvar and anal intraepithelial neoplasia in a HIV seropositive child--therapeutic result: case report

Autor: N M Speck, de Góis, R R L, Costa, F, Kesselring, V G, de Freitas, J C L, Ribalta, M P, Kobata, N S, Taha

Publikováno v: Clinical and experimental obstetricsgynecology. 32(2)

A case report of a HIV seropositive 8-year-old child with vulvar and anal border neoplasia, both grade 3, and the adopted therapeutic management are presented. The mother reported the history of a progressively growing verrucous lesion in the vulva s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94b2f1ce199ea393035eed16bd2b4143
https://pubmed.ncbi.nlm.nih.gov/16108402

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The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

Autor: J, Bravo, Z, Li, N A, Speck, A J, Warren

Publikováno v: Nature structural biology. 8(4)

We have determined the structure, at 2.6 A resolution, of the AML1 (Runx1) Runt domain--CBF beta--DNA ternary complex, the most common target for mutations in human leukemia. The structure reveals that the Runt domain DNA binding mechanism is unique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91a97e3a841d4ba988650120303b9bbf
https://pubmed.ncbi.nlm.nih.gov/11276260

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CFU-S(11) activity does not localize solely with the aorta in the aorta-gonad-mesonephros region

Autor: M F, de Bruijn, M C, Peeters, T, Luteijn, P, Visser, N A, Speck, E, Dzierzak

Publikováno v: Blood. 96(8)

The aorta-gonad-mesonephros (AGM) region is a potent hematopoietic site in the midgestation mouse conceptus and first contains colony-forming units-spleen day 11 (CFU-S(11)) at embryonic day 10 (E10). Because CFU-S(11) activity is present in the AGM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::526a54be9a863d90b30647a5fe1711a8
https://pubmed.ncbi.nlm.nih.gov/11023528

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Solution structure of core binding factor beta and map of the CBF alpha binding site

Autor: X, Huang, J W, Peng, N A, Speck, J H, Bushweller

Publikováno v: Nature structural biology. 6(7)

The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::457467085eb70e51b937cdddf914c490
https://pubmed.ncbi.nlm.nih.gov/10404216

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Core-binding factor: a central player in hematopoiesis and leukemia

Autor: N A, Speck, T, Stacy, Q, Wang, T, North, T L, Gu, J, Miller, M, Binder, M, Marín-Padilla

Publikováno v: Cancer research. 59

Consistent chromosomal rearrangements are found in a large number of hematopoietic tumors. In many cases, these rearrangements disrupt genes whose normal function is required for the proper development of blood cells. Excellent examples are the chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04e9d5bfd274bc3393291b9a6c899447
https://pubmed.ncbi.nlm.nih.gov/10197598

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