Zobrazeno 1 - 10
of 29
pro vyhledávání: '"N A, Peppas"'
Publikováno v:
Int J Pharm
Cationic polymers have garnered significant interest for their utility in intracellular drug delivery and gene therapy. However, due to their associated toxicities, novel synthesis approaches must be explored to develop materials that are biocompatib
Autor:
N-A, Peppas
Publikováno v:
Annales pharmaceutiques francaises. 64(4)
Biomaterials are widely used in numerous medical applications. Chemical engineering has played a central role in this research and development. We review herein polymers as biomaterials, materials and approaches used in drug and protein delivery syst
Publikováno v:
Pharmaceutical research. 19(3)
The objectives of this work were (i) to study and understand the physicochemical phenomena which are involved in the swelling and drug release from hydrophilic matrix tablets using the "sequential layer" model, and (ii) to predict the effect of the i
Publikováno v:
Journal of biomedical materials research. 56(3)
The "living" radical polymerization with an iniferter was used to create micropatterned biomedical surfaces. Novel, photosensitive biomedical polymers were created by the incorporation of dithiocarbamate groups from iniferters. A second monomer layer
Autor:
J, Siepmann, N A, Peppas
Publikováno v:
Pharmaceutical research. 17(10)
The aims of this study were (i) to elucidate the transport mechanisms involved in drug release from hydrophilic matrices; and (ii) to develop an improved mathematical model allowing quantitative predictions of the resulting release kinetics.Our previ
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 65(1-2)
Mucoadhesive controlled-release devices can improve the effectiveness of a drug by maintaining the drug concentration between the effective and toxic levels, inhibiting the dilution of the drug in the body fluids, and allowing targeting and localizat
Autor:
N A Peppas, Anthony M. Lowman
Publikováno v:
Journal of biomaterials science. Polymer edition. 10(9)
We report on the preparation and properties of hydrogels of poly(methacrylic acid-g-ethylene glycol) that exhibit pH-responsive swelling behavior due to the reversible formation/dissociation of interpolymer complexes. Because of their nature, these m
Publikováno v:
Pharmaceutical research. 16(11)
The purpose of this study was to investigate the drug release mechanisms from hydroxypropyl methylcellulose (HPMC)-matrices, and to develop a new model for quantitative predictions of controlled drug delivery.The dissolved mass of pure HPMC-matrices
Autor:
B. Narasimhan, N. A. Peppas
Publikováno v:
ACS Symposium Series ISBN: 9780841235885
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59f185250a7a8df15a08bcccb671063
https://doi.org/10.1021/bk-1998-0710.ch028
https://doi.org/10.1021/bk-1998-0710.ch028
Publikováno v:
Journal of biomedical materials research. 36(1)
Novel semicrystalline, poly(vinyl alcohol) (PVA)-based phase erosion systems were developed. The rate of drug release from these systems is controlled by the rate of crystal dissolution. PVA devices loaded with metronidazole were exposed to temperatu