Zobrazeno 1 - 10
of 12
pro vyhledávání: '"N A, Lokker"'
Autor:
N A Lokker, Paul J. Godowski
Publikováno v:
Journal of Biological Chemistry. 268:17145-17150
Our previous studies have suggested that a derivative of hepatocyte growth factor (HGF), HGF/NK2, containing the coding sequences for the N-terminal hairpin and first two kringle domains, is sufficient to mediate high affinity binding to the HGF rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc066f051f6681cc0a1d044937ba911c
https://doi.org/10.1016/s0021-9258(19)85314-0
https://doi.org/10.1016/s0021-9258(19)85314-0
Publikováno v:
Journal of Biological Chemistry. 267:26166-26171
The receptor for hepatocyte growth factor (HGF) is the product of the c-met proto-oncogene, a membrane-spanning tyrosine kinase receptor. To facilitate analysis of HGF and its receptor (HGFr), we expressed and purified a chimeric protein containing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98dc6f21dca11cdc1ff0062c619a644
https://doi.org/10.1016/s0021-9258(18)35731-4
https://doi.org/10.1016/s0021-9258(18)35731-4
Publikováno v:
Journal of Biological Chemistry. 266:10624-10631
Recombinant human interleukin-3 (rhuIL-3) variants were generated by site-directed mutagenesis and expression in Escherichia coli. Amino acid deletions and substitutions were made in the previously identified epitopes of two huIL-3-specific neutraliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::496e7e90a295531a0f4456abae9e3499
https://doi.org/10.1016/s0021-9258(18)99269-0
https://doi.org/10.1016/s0021-9258(18)99269-0
Publikováno v:
The Journal of Immunology. 146:893-898
The epitopes of neutralizing mAb were mapped in order to identify a receptor binding site on human IL-3 (huIL-3). To initiate this structure and activity analysis, four neutralizing mAb were selected on the basis of preventing rhuIL-3 stimulated prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cdecdb35c31f81bab421c636ef8780f
https://doi.org/10.4049/jimmunol.146.3.893
https://doi.org/10.4049/jimmunol.146.3.893
Autor:
J C, Yu, N A, Lokker, S, Hollenbach, M, Apatira, J, Li, A, Betz, D, Sedlock, S, Oda, Y, Nomoto, K, Matsuno, S, Ide, E, Tsukuda, N A, Giese
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(3)
Exaggerated or inappropriate signaling by the platelet-derived growth factor receptor (PDGFR) tyrosine kinase has been implicated in a wide variety of diseases. Thus, a series of piperazinyl quinazoline compounds were identified as potent antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bdfd0fb2fc549768476789068ffdf7d
https://pubmed.ncbi.nlm.nih.gov/11504817
https://pubmed.ncbi.nlm.nih.gov/11504817
Autor:
N A, Lokker, J P, O'Hare, A, Barsoumian, J E, Tomlinson, V, Ramakrishnan, L J, Fretto, N A, Giese
Publikováno v:
The Journal of biological chemistry. 272(52)
The biological effects of platelet-derived growth factor (PDGF) are mediated by alpha- and beta-PDGF receptors (PDGFR), which have an intracellular tyrosine kinase domain and an extracellular region comprising five immunoglobulin-like domains (D1-D5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0215b4d1c2ccd6288356a7f17672fc5a
https://pubmed.ncbi.nlm.nih.gov/9407086
https://pubmed.ncbi.nlm.nih.gov/9407086
Autor:
N A, Lokker, P J, Godowski
Publikováno v:
The Journal of biological chemistry. 268(23)
Our previous studies have suggested that a derivative of hepatocyte growth factor (HGF), HGF/NK2, containing the coding sequences for the N-terminal hairpin and first two kringle domains, is sufficient to mediate high affinity binding to the HGF rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7491c6947cfde5c660f5c0fc2274f235
https://pubmed.ncbi.nlm.nih.gov/8349603
https://pubmed.ncbi.nlm.nih.gov/8349603
Publikováno v:
The Journal of biological chemistry. 267(36)
The receptor for hepatocyte growth factor (HGF) is the product of the c-met proto-oncogene, a membrane-spanning tyrosine kinase receptor. To facilitate analysis of HGF and its receptor (HGFr), we expressed and purified a chimeric protein containing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ae3c1a2bda3f0a2f07c4e45f56baa8b
https://pubmed.ncbi.nlm.nih.gov/1334493
https://pubmed.ncbi.nlm.nih.gov/1334493
Publikováno v:
The EMBO journal. 11(7)
Hepatocyte growth factor (HGF) is a potent mitogen for parenchymal liver, epithelial and endothelial cells. Structurally, it has similarities to kringle-containing serine proteases, although it does not possess proteolytic activity. A structure-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb2a7f45e8632f7c2b0d8cccc1dcdba
https://pubmed.ncbi.nlm.nih.gov/1321034
https://pubmed.ncbi.nlm.nih.gov/1321034
Publikováno v:
Lymphokine and cytokine research. 10(4)
The human interleukin-3 gene was cloned in 1986 and the biochemical and biological properties of recombinant human interleukin-3 (rhuIL-3) protein were described. In this report we compare rhuIL-3 with nonrecombinant, natural huIL-3, purified from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12a06c7b22ca573374bfe0573fd04590
https://pubmed.ncbi.nlm.nih.gov/1932378
https://pubmed.ncbi.nlm.nih.gov/1932378