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Akademický článek

Cytotoxicity activities and chemical characteristics of exopolysaccharides and intracellular polysaccharides of Physarum polycephalum microplasmodia

Autor: Tuyen T. H. Do, Tran N. B. Lai, Steven L. Stephenson, Hanh T. M. Tran

Publikováno v: BMC Biotechnology, Vol 21, Iss 1, Pp 1-15 (2021)

Abstract Background Microbial polysaccharides have been reported to possess remarkable bioactivities. Physarum polycephalum is a species of slime mold for which the microplasmodia are capable of rapid growth and can produce a significant amount of ce

Externí odkaz: https://doaj.org/article/f214305fc3714543969863ddaf0b9d57

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Akademický článek

Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency

Autor: Mei Hua Gao, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Young Chul Kim, Viet Anh Nguyen Huu, Dorota Skowronska-Krawczyk, Louise Lantier, Raag Bhargava, H. Kirk Hammond

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 220-233 (2020)

Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin

Externí odkaz: https://doaj.org/article/828e78bc7b3643b49492393e8da28c44

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Akademický článek

Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal

Autor: Dimosthenis Giamouridis, BS, MS, Mei Hua Gao, PhD, N. Chin Lai, PhD, Zhen Tan, PhD, Young Chul Kim, PhD, Tracy Guo, BS, Atsushi Miyanohara, PhD, W. Matthijs Blankesteijn, PhD, Erik Biessen, PhD, H. Kirk Hammond, MD

Publikováno v: JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)

Summary: UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plas

Externí odkaz: https://doaj.org/article/7f669bc55c904d3d97cf15fd9a30d1e9

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Urocortin 2 Gene Transfer for Systolic and Diastolic Dysfunction Due to Chronically Increased Left Ventricular Pressure

Autor: N. Chin Lai, Zhen Tan, Dimosthenis Giamouridis, Mei Hua Gao, H. Kirk Hammond

Publikováno v: Human Gene Therapy. 33:1091-1100

We used transverse aortic constriction (TAC) in mice to test the hypothesis thatiurocortin 2/i(iUcn2/i) gene transfer would increase left ventricular (LV) systolic and diastolic function in the pressure-stressed LV. Three groups were studied: (1) con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0499e632fa3dc48effbab55a8a54d4a
https://doi.org/10.1089/hum.2022.132

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Akademický článek

Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance.

Autor: Young Chul Kim, Agnieszka D Truax, Dimosthenis Giamouridis, N Chin Lai, Tracy Guo, H Kirk Hammond, Mei Hua Gao

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0224428 (2019)

IntroductionUrocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose dispo

Externí odkaz: https://doaj.org/article/a76d1ce9339e432589e71472f8999c89

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Akademický článek

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Akademický článek

Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Autor: Mei Hua Gao, PhD, N. Chin Lai, PhD, Dimosthenis Giamouridis, MSc, Young Chul Kim, PhD, Zhen Tan, PhD, Tracy Guo, BS, Wolfgang H. Dillmann, MD, Jorge Suarez, PhD, H. Kirk Hammond, MD

Publikováno v: JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 617-629 (2016)

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increas

Externí odkaz: https://doaj.org/article/c3d4b2955ed24706befb04be3dee1927

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Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation.

Autor: Mei Hua Gao, N Chin Lai, Dimosthenis Giamouridis, Young Chul Kim, Tracy Guo, H Kirk Hammond

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0181282 (2017)

Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. We previously generated a catalytically inactive mutant of AC6 (AC6mut) t

Externí odkaz: https://doaj.org/article/a04ae54f71fd4853b07adb6d4178d6d9

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