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Akademický článek

Happy-ICP: single-centre cohort of 184 telemetric intracranial pressure monitors

Autor: P. Banks, A. Pandit, A. Toma, S. Thompson, N. Dubé-Fuller, L. Thorne, L. Watkins

Publikováno v: Brain and Spine, Vol 1, Iss , Pp 100744- (2021)

Externí odkaz: https://doaj.org/article/1fdf59c3bb6948d5a949c14d93a9d0be

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Pre– and Post–Sexual Maturity Liver-specific ERα Knockout Does Not Impact Hepatic Mitochondrial Function

Autor: Kelly N Z Fuller, Julie Allen, Roshan Kumari, Jephte Y Akakpo, Meghan Ruebel, Kartik Shankar, John P Thyfault

Publikováno v: Journal of the Endocrine Society. 7

Compared with males, premenopausal women and female rodents are protected against hepatic steatosis and present with higher functioning mitochondria (greater hepatic mitochondrial respiration and reduced H2O2 emission). Despite evidence that estrogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::723fc06848ef0fdbab79fd42edbf2f13
https://doi.org/10.1210/jendso/bvad053

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Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism

Autor: Alec B. Chaves, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Kelly N. Z. Fuller, Blaise Stearns, Andrew Ludlow, David L. Williamson, Joseph A. Houmard, Jacob M. Haus

Publikováno v: J Appl Physiol (1985)

Thioredoxin-interacting protein (TXNIP) negatively effects the redox state and growth signaling via its interactions with thioredoxin (TRX) and regulated in development and DNA damage response 1 (REDD1), respectively. TXNIP expression is downregulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f25dbb45f29a20af1e1a5f92027177
https://pubmed.ncbi.nlm.nih.gov/34941434

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Akademický článek

Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer’s Disease

Autor: Kelly N. Z. Fuller, Edwin R. Miranda, John P. Thyfault, Jill K. Morris, Jacob M. Haus

Publikováno v: Mediators of Inflammation, Vol 2018 (2018)

Although there is evidence for metabolic dysfunction and chronic inflammation in Alzheimer’s disease (AD), circulating levels of soluble receptor for advanced glycation end products (sRAGE) and the receptor for advanced glycation end products (RAGE

Externí odkaz: https://doaj.org/article/93d84389b27d4547bad7d9521a4f901a

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Oral combined contraceptives induce liver mitochondrial reactive oxygen species and whole-body metabolic adaptations in female mice

Autor: Kelly N. Z. Fuller, Colin S. McCoin, Harrison Stierwalt, Julie Allen, Shivam Gandhi, Christopher G. R. Perry, Purevsuren Jambal, Kartik Shankar, John P. Thyfault

Publikováno v: The Journal of physiologyReferences. 600(24)

Compared to age-matched men, pre-menopausal women show greater resilience against cardiovascular disease (CVD), hepatic steatosis, diabetes and obesity - findings that are widely attributed to oestrogen. However, meta-analysis data suggest that curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2790309b5b3d5d8df812e4dad8393e7
https://pubmed.ncbi.nlm.nih.gov/36326014

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Estradiol treatment or modest exercise improves hepatic health and mitochondrial outcomes in female mice following ovariectomy

Autor: Claire J. Houchen, Michael A. Choi, Kelly N. Z. Fuller, Alex T. Von Schulze, Colin S. McCoin, John P. Thyfault

Publikováno v: Am J Physiol Endocrinol Metab

We recently reported that compared with males, female mice have increased hepatic mitochondrial respiratory capacity and are protected against high-fat diet-induced steatosis. Here, we sought to determine the role of estrogen in hepatic mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ba26a798f6a733a66bdf9f75238a0c
https://doi.org/10.1152/ajpendo.00013.2021

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Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice

Autor: Kelly N. Z. Fuller, Julie Allen, Colin S. McCoin, Devin C. Koestler, Shelby Bell-Glenn, John P. Thyfault, Gerald W. Dorn

Publikováno v: J Appl Physiol (1985)

Both lipid oversupply and poor mitochondrial function (low respiration and elevated H(2)O(2) emission) have been implicated in the development of hepatic steatosis and liver injury. Mitophagy, the targeted degradation of low-functioning mitochondria,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58b6a62e000d63b98bad67d3f481e08
https://doi.org/10.1152/japplphysiol.00035.2020

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Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity

Autor: Kartik Shankar, Alex T. Von Schulze, John P. Thyfault, Devin C. Koestler, Claire J. Houchen, Julie Allen, Qing Xia, Gerald W. Dorn nd, E. Matthew Morris, Adrianna Maurer, Kelly N. Z. Fuller, Colin S. McCoin

Publikováno v: Am J Physiol Endocrinol Metab

The impact of sexual dimorphism and mitophagy on hepatic mitochondrial adaptations during the treatment of steatosis with physical activity are largely unknown. Here, we tested if deficiencies in liver-specific peroxisome proliferative activated-rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ecafaeb2fc1f025e290ef228c93fa1
https://doi.org/10.1152/ajpendo.00098.2019

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