Zobrazeno 1 - 10
of 97
pro vyhledávání: '"N A, Berger"'
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent
Externí odkaz:
https://doaj.org/article/028fa80da48448499589471060a20e19
Autor:
Shaun Moore, N. Daniel Berger, Martijn S. Luijsterburg, Cortt G. Piett, Fintan K. T. Stanley, Christoph U. Schräder, Shujuan Fang, Jennifer A. Chan, David C. Schriemer, Zachary D. Nagel, Haico van Attikum, Aaron A. Goodarzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Oxidative DNA damage is associated with nucleosome respacing and transcriptional changes requiring chromatin remodeling enzymes. Here, the authors reveal that the CHD6 remodeler is a DNA damage response factor that relocates to damaged sites and prom
Externí odkaz:
https://doaj.org/article/a1d6db47cd974c2ebdb72cd40605819e
Autor:
S. Bakshi, H. M. Schmidt, A. E. Baskin, C. M. Croniger, C. L. Thompson, T. Bonfield, D. Fletcher, N. A. Berger
Publikováno v:
Obesity Science & Practice, Vol 4, Iss 6, Pp 526-534 (2018)
Summary Objective Retinol binding protein 4 (RBP4) transports vitamin A (Retinol) in the blood and contributes mechanistically to the linkage between obesity, insulin resistance and associated comorbidities including type 2 diabetes mellitus, coronar
Externí odkaz:
https://doaj.org/article/d411835d1e414896b1fa0605db503ffb
Autor:
N Daniel Berger, Peter M Brownlee, Myra J Chen, Hali Morrison, Katalin Osz, Nicolas P Ploquin, Jennifer A Chan, Aaron A Goodarzi
Publikováno v:
NAR cancer. 4(2)
Cranial irradiation is part of the standard of care for treating pediatric brain tumors. However, ionizing radiation can trigger serious long-term neurologic sequelae, including oligodendrocyte and brain white matter loss enabling neurocognitive decl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6055b50fac8ad5de12de1ee971af81eb
https://pubmed.ncbi.nlm.nih.gov/35425901
https://pubmed.ncbi.nlm.nih.gov/35425901
Autor:
Ana Nikolic, Anna Bobyn, Francesca Maule, Katrina Ellestad, Seungil Paik, Sajid Marhon, Parinaz Mehdipour, Xuequng Lun, Michael Johnston, Christopher Gafiuk, Franz Zemp, Yaoqing Shen, Nicoletta Ninkovic, Elodie Labit, N Daniel Berger, Duncan Brownsey, John Kelly, Jeff Biernaskie, Peter Dirks, Darren Derksen, Steven J M Jones, Donna L Senger, Jennifer Chan, Douglas J Mahoney, Daniel de Carvalho, Marco Gallo
Publikováno v:
Neuro-Oncology. 24:vii34-vii34
Glioblastoma is a highly malignant tumour driven by a subset of self-renewing cells termed glioblastoma stem cells. This self-renewal phenotype is largely epigenetically driven, however, the exact epigenetic mechanisms underpinning it are poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7753ee094ff6faa8ae8787b56a61f6b5
https://doi.org/10.1093/neuonc/noac209.133
https://doi.org/10.1093/neuonc/noac209.133
Autor:
Michael J. Johnston, Parinaz Mehdipour, Douglas J. Mahoney, Katrina Ellestad, Christopher J Gafuik, Jennifer A. Chan, Ana Nikolic, Daniel D. De Carvalho, Nicoletta Ninkovic, Steven J.M. Jones, Xueqing Lun, Anna Bobyn, Peter B. Dirks, Francesca Maule, Yaoqing Shen, Darren J. Derksen, N. Daniel Berger, Donna L. Senger, Duncan K. Brownsey, Marco Gallo, Franz J. Zemp, Sajid A. Marhon
SUMMARYSelf-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe58287f85fb3fd3054c88f6e24aee0
https://doi.org/10.1101/2021.02.23.432465
https://doi.org/10.1101/2021.02.23.432465
Autor:
Patrick J. Cimino, Shazreh Bukhari, Hiba Omairi, Gregory Cairncross, Alexandra Bohm, Cameron J. Grisdale, Jennifer A. Chan, Cindy Chen, Raymond C B Wong, Haley Pedersen, Yaoqing Shen, Lori Maxwell, John Kelly, N. Daniel Berger, Michael D. Blough, Yaping Yu, Steven J.M. Jones, Jessica DePetro, Amanda Gerber, Eric C. Holland, Erin Chahley, V. Wee Yong, Samuel Weiss, Samuel Lawn, Reza Mirzaei, Nicholas Chahley, Carmen Binding, Kaitlin Thomas, Matthaeus Ware
BackgroundImagining ways to prevent or treat glioblastoma (GBM) have been hindered by a lack of understanding of its pathogenesis. Although PDGF-AA overexpression may be an early event, critical details of the core biology are lacking. Existing PDGF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bebf32b06aca7bc75919a5a602ee6e
https://doi.org/10.1101/837138
https://doi.org/10.1101/837138
Autor:
Jennifer A. Chan, Martijn S. Luijsterburg, Shujuan Fang, N. Daniel Berger, Fintan K. T. Stanley, Zachary D. Nagel, Shaun Moore, Cortt G. Piett, Christoph U. Schräder, Haico van Attikum, David C. Schriemer, Aaron A. Goodarzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10
Nature Communications, 10
Cell survival after oxidative DNA damage requires signaling, repair and transcriptional events often enabled by nucleosome displacement, exchange or removal by chromatin remodeling enzymes. Here, we show that Chromodomain Helicase DNA-binding protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca94357d6ff06616a818566fa9683a7c
https://doi.org/10.1038/s41467-018-08111-y
https://doi.org/10.1038/s41467-018-08111-y
Autor:
Hali Morrison, Jennifer A. Chan, John M Danforth, Fintan K. T. Stanley, James E Johnston, N. Daniel Berger, Greg Pierce, Tyler S Warnock, Darren R. Brenner, Jennifer A. Cobb, Dustin D. Pearson, N Ploquin, Aaron A. Goodarzi
Publikováno v:
Nucleic Acids Research
Ionizing radiation (IR) is environmentally prevalent and, depending on dose and linear energy transfer (LET), can elicit serious health effects by damaging DNA. Relative to low LET photon radiation (X-rays, gamma rays), higher LET particle radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1a96445037cc6fb51d53e4ebaaeb05
https://doi.org/10.1093/nar/gkaa782
https://doi.org/10.1093/nar/gkaa782