Zobrazeno 1 - 10
of 3 377
pro vyhledávání: '"N -glycan"'
Autor:
Meiyappan Lakshmanan, Sean Chia, Kuin Tian Pang, Lyn Chiin Sim, Gavin Teo, Shi Ya Mak, Shuwen Chen, Hsueh Lee Lim, Alison P. Lee, Farouq Bin Mahfut, Say Kong Ng, Yuansheng Yang, Annie Soh, Andy Hee-Meng Tan, Andre Choo, Ying Swan Ho, Terry Nguyen-Khuong, Ian Walsh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2497-2506 (2024)
N-glycosylation can have a profound effect on the quality of mAb therapeutics. In biomanufacturing, one of the ways to influence N-glycosylation patterns is by altering the media used to grow mAb cell expression systems. Here, we explore the potentia
Externí odkaz:
https://doaj.org/article/8c61532e278a4848aa34e06e0575d137
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1156-1171 (2024)
N-glycans play important roles in a variety of biological processes. In recent years, analytical technologies with high resolution and sensitivity have advanced exponentially, enabling analysts to investigate N-glycomic changes in different states. S
Externí odkaz:
https://doaj.org/article/ab67a28dbeae4476b11eacd346222615
Autor:
Zhen Cao, Zejian Zhang, Yuanyang Wang, Yilin Zhu, Zepeng Li, Xiaobin Li, Yingmo Shen, Jie Chen, Ziwen Liu
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35908- (2024)
Introduction: Although inguinal hernia (IH) is prevalent in elderly males, research on its specific diagnostic biomarkers is limited. Protein N-glycosylation is one of the most important and ubiquitous post-translational modifications and often resul
Externí odkaz:
https://doaj.org/article/ed52bce489974c3b88cd00cd43e2f026
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Background Congenital disorders of glycosylation (CDG) are a type of inborn error of metabolism (IEM) resulting from defects in glycan synthesis or failed attachment of glycans to proteins or lipids. One rare type of CDG is caused by homozyg
Externí odkaz:
https://doaj.org/article/f33d57c491b84355b6af51e85435ebf6
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
N-glycosylation influences the effectiveness of immune globulin G (IgG) and thus the immunological downstream responses of immune cells. This impact arises from the presence of N-glycans within the Fc region, which not only alters the conformation of
Externí odkaz:
https://doaj.org/article/28680a13ac094dca976fa565d449a5b2
Autor:
Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang
Publikováno v:
Engineering, Vol 26, Iss , Pp 151-158 (2023)
The aim of this study was to explore the role of serum N-glycomic-derived models in diagnosing significant liver fibrosis and cirrhosis in 285 chronic hepatitis B (CHB) patients with normal (
Externí odkaz:
https://doaj.org/article/b64ef5a3e5b5474b8336343a4c8db521
Publikováno v:
Applied Sciences, Vol 14, Iss 16, p 7320 (2024)
N-glycan, a critical quality attribute (CQA) of monoclonal antibodies, profoundly impacts potency, immunogenicity, safety, and clinical efficiency. Therefore, N-glycan should be monitored and controlled during development. The conventional 2-AB metho
Externí odkaz:
https://doaj.org/article/4f0c4fdddcc44aa3858a957cbbd4622f
Autor:
Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki
Publikováno v:
eLife, Vol 12 (2024)
This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model wa
Externí odkaz:
https://doaj.org/article/ad0a205eda70458e8bba0b5b1842d893
Autor:
Michael Sy, Barbara L. Newton, Judy Pawling, Ken L. Hayama, Andres Cordon, Zhaoxia Yu, Jens Kuhle, James W. Dennis, Alexander U. Brandt, Michael Demetriou
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. While B cell depletion and blockade/sequestration of T
Externí odkaz:
https://doaj.org/article/26ed65cec5fb49f382b672413fb8685d
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4345 (2024)
Marine algal lectins specific for high-mannose N-glycans have attracted attention because they strongly inhibit the entry of enveloped viruses, including influenza viruses and SARS-CoV-2, into host cells by binding to high-mannose-type N-glycans on v
Externí odkaz:
https://doaj.org/article/3df0f359c2b54535a05c716a3192b5b5