Zobrazeno 1 - 10
of 3 547
pro vyhledávání: '"N‐glycans"'
Autor:
Ryan Haryadi, Kah Fai Chan, Pao Chun Lin, Yun Lei Tan, Corrine Wan, Wahyu Shahreel, Shi Jie Tay, Terry Nguyen-Khuong, Ian Walsh, Zhiwei Song
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract This report describes the development and characterization of a comprehensive collection of CHO cell glycosylation mutants with significant potential for advancing glycobiology and biotechnology. EPO-Fc and trastuzumab, two model molecules,
Externí odkaz:
https://doaj.org/article/75542e73d23a4b45832f4c42a7c4b5fe
Autor:
John MacSharry, Zsuzsanna Kovács, Yongjing Xie, Barbara Adamczyk, Caitriona Walsh, Fiona Reidy, Fionnuala M. McAuliffe, Mark T Kilbane, Patrick J Twomey, Pauline M. Rudd, Mary Wingfield, Michael Butler, Douwe van Sinderen, Louise Glover, Radka Saldova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Endometriosis is a chronic systemic disease, which results in endometrial-type tissue growing outside the uterus, and affects approximately 10% of reproductive-aged women worldwide. Its aetiology is poorly understood, and there is currently
Externí odkaz:
https://doaj.org/article/ef1996e4550a4323a3450985ca3ec339
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 3, Pp 519-538 (2024)
Aberrant N-glycosylation has been associated with progression of the pediatric cancer neuroblastoma (NB) but remains understudied. Here we investigated oligomannose N-glycans in NB by genetic editing of MGAT1 in a human NB cell line, BE(2)-C, called
Externí odkaz:
https://doaj.org/article/b6c5de65dfa54900bd2d7f1d3f027b91
Autor:
Jordan S. Dialpuri, Haroldas Bagdonas, Lucy C. Schofield, Phuong Thao Pham, Lou Holland, Jon Agirre
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 931-939 (2024)
The remediation of the carbohydrate data of the Protein Data Bank (PDB) has brought numerous enhancements to the findability and interpretability of deposited glycan structures, yet crucial quality indicators are either missing or hard to find on the
Externí odkaz:
https://doaj.org/article/c76ce5f10712417281506b4c1f0948fc
Autor:
Omayra C. Bolaños-Martínez, Anna Urbanetz, Daniel Maresch, Richard Strasser, Sornkanok Vimolmangkang
Publikováno v:
Biotechnology Reports, Vol 45, Iss , Pp e00865- (2025)
The production of cannabinoid compounds such as Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabichromene (CBC) with potential pharmaceutical applications is growing sharply. However, challenges such as the low yield of minor cannabinoids
Externí odkaz:
https://doaj.org/article/dba8ef821eb54232a47426674b6a18f1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Identifying factors required for spermatogenesis is important for understanding mechanisms of male fertility. Inactivation of either the Mgat1 or Man2a2 gene leads to a block in spermatogenesis causing infertility in male mice. MGAT1 GlcNAc-transfera
Externí odkaz:
https://doaj.org/article/9ec1d3240e124406b8695ae46ae4042a
Autor:
Joy Solomon, Cristian D. Gutierrez-Reyes, Jesús Chávez-Reyes, Sherifdeen Onigbinde, Bruno A. Marichal-Cancino, Carlos H. López-Lariz, Mia Beck, Yehia Mechref
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionGlyphosate-based herbicides (GBHs) have been shown to have significant neurotoxic effects, affecting both the structure and function of the brain, and potentially contributing to the development of neurodegenerative disorders. Despite the
Externí odkaz:
https://doaj.org/article/2fee6962737346a5845b49993b3e5f5a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 607-620 (2024)
In the beginning was the word. But there were no words for N-glycans, at least, no simple words. Next to chemical formulas, the IUPAC code can be regarded as the best, most reliable and yet immediately comprehensible annotation of oligosaccharide str
Externí odkaz:
https://doaj.org/article/4202f07b6cc44494b9726de900e844d7
Autor:
Henrique Fernandes-Mendes, Catarina M. Azevedo, Mónica Garrido, Carolina Lemos, Isabel Pedroto, Salomé S. Pinho, Ricardo Marcos-Pinto, Ângela Fernandes
Publikováno v:
GE: Portuguese Journal of Gastroenterology, Pp 1-13 (2024)
Introduction: The serrated pathway contributes to interval colorectal cancers, highlighting the need for new biomarkers to assess lesion progression risk. The β1,6-GlcNAc branched N-glycans expression in CRC cells was associated with an invasive phe
Externí odkaz:
https://doaj.org/article/445fb651199849ddae5cb65f18a68918
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9165-9180 (2023)
A lack of complex and hybrid types of N-glycans in mice is embryonically lethal due to neural tube maldevelopment. N-acetylglucosaminyltransferase-I (GnT-I; Mgat1) catalyzes a required step for converting oligomannose N-glycans into hybrid and comple
Externí odkaz:
https://doaj.org/article/894f12d966204efe8827804e02a4400e