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In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome

Autor: Zheng, Z., Xu, Y., Krügel, U., Schaefer, M., Grune, T., Nürnberg, B., Köhler, M.B., Gollasch, M., Tsvetkov, D., Marko, L.

Publikováno v: International journal of molecular sciences. 23(12)

Metabolic syndrome is a significant worldwide public health challenge and is inextricably linked to adverse renal and cardiovascular outcomes. The inhibition of the transient receptor potential cation channel subfamily C member 6 (TRPC6) has been fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a43adc32c468f68b43731cfd9c8f7ff
https://pubmed.ncbi.nlm.nih.gov/35743312

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses

Autor: Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E

Publikováno v: eLife
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

Cyclic AMP (cAMP) is involved in many biological processes but little is known regarding its role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent mechanism) regulates conventional type-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d9b12a68ef449584b9840ecf9031e52
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=5710

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Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids

Autor: Riehle, M., Tsvetkov, D., Gohlke, B.O., Preissner, R., Harteneck, C., Gollasch, M., Nürnberg, B.

Transient receptor potential (TRP) channels represent a superfamily of unselective cation channels that are subdivided into seven subfamilies based on their sequence homology and differences in gating and functional properties. Little is known about

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::eedb1639fe6b46c906db0fc7a602169b
http://edoc.mdc-berlin.de/17406/2/17406suppl.pdf