Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Núria Villegas"'
Autor:
Martino Bertoni, Miquel Duran-Frigola, Pau Badia-i-Mompel, Eduardo Pauls, Modesto Orozco-Ruiz, Oriol Guitart-Pla, Víctor Alcalde, Víctor M. Diaz, Antoni Berenguer-Llergo, Isabelle Brun-Heath, Núria Villegas, Antonio García de Herreros, Patrick Aloy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Small molecules bioactivity descriptors are enriched representations of compounds, reaching beyond chemical structures and capturing their known biological properties. Here the authors present a collection of deep neural networks able to infer bioact
Externí odkaz:
https://doaj.org/article/ea240240f3214f9098521acfd799be30
Autor:
Federica Battistini, Pablo D. Dans, Montserrat Terrazas, Chiara L. Castellazzi, Guillem Portella, Mireia Labrador, Núria Villegas, Isabelle Brun-Heath, Carlos González, Modesto Orozco
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11 (2021)
We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical experiments and NMR spectroscopy, we found that Ten-Eleven translocation (TET) dioxygenases ge
Externí odkaz:
https://doaj.org/article/1f6de9e1bc4c478a93769f666de093a8
Autor:
Patrick Aloy, Núria Villegas, Martino Bertoni, Miquel Duran-Frigola, Modesto Orozco-Ruiz, Oriol Guitart-Pla, Pau Badia-i-Mompel, Antonio García de Herreros, Antoni Berenguer-Llergo, Eduardo Pauls, Víctor M. Díaz, Víctor Alcalde, Isabelle Brun-Heath
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Chemical descriptors encode the physicochemical and structural properties of small molecules, and they are at the core of chemoinformatics. The broad release of bioactivity data has prompted enriched representations of compounds, reaching beyond chem
Autor:
Chiara Lara Castellazzi, Montserrat Terrazas, Pablo D. Dans, Guillem Portella, Federica Battistini, Isabelle Brun-Heath, Carlos González, Núria Villegas, Modesto Orozco, Mireia Labrador
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009547 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Computational Biology, Vol 17, Iss 11 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS Computational Biology, Vol 17, Iss 11, p e1009547 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Computational Biology, Vol 17, Iss 11 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Funder: Government of Spain
Funder: Instituci�� Catalana de Recerca i Estudis Avancats
Funder: Programa de Desarrollo de las Ciencias Basicas
Funder: Sistema Nacional de Investigadores, Agencia Nacional de Investigaci��n e Inno
Funder: Instituci�� Catalana de Recerca i Estudis Avancats
Funder: Programa de Desarrollo de las Ciencias Basicas
Funder: Sistema Nacional de Investigadores, Agencia Nacional de Investigaci��n e Inno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701e44a65ccc4b6b101da75fa732ff42
http://hdl.handle.net/10261/259111
http://hdl.handle.net/10261/259111
Autor:
Diana Buitrago, Anna Esteve-Codina, Isabelle Brun Heath, Mireia Labrador, Juan Pablo Arcon, Ivo Gut, Rafael Lema, Simon Heath, Pablo D. Dans, Marta Gut, Oscar Flores, Julie Blanc, Modesto Orozco, David Bellido, Núria Villegas
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Determining the effect of DNA methylation on chromatin structure and function in higher organisms is challenging due to the extreme complexity of epigenetic regulation. We studied a simpler model system, budding yeast, that lacks DNA methylation mach
Autor:
Guillem Portella, Mireia Labrador, Chiara Lara Castellazzi, Montserrat Terrazas, Federica Battistini, Pablo D. Dans, Isabelle Brun-Heath, Núria Villegas, Modesto Orozco, Carlos González
We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical experiments and NMR spectroscopy, we found that Ten-Eleven translocation (TET) dioxygenases ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b00c20bf0bd2aa82422782eb0ee5cd9
https://doi.org/10.1101/2020.09.17.285452
https://doi.org/10.1101/2020.09.17.285452
Autor:
Rory Johnson, Roderic Guigó, Montserrat Terrazas, Anna Aviñó, Carme Arnan, Dani Sánchez, Modesto Orozco, Isabelle Brun-Heath, Carlos Pulido-Quetglas, Núria Villegas, Vito Genna, Guillem Portella, Ramon Eritja
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Chem
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chem
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
We analyze the physical origin and the chemical and biological consequences of the asymmetry that occurs in DNA·RNA hybrids when the purine/pyrimidine (Pu/Py) ratio is different in the DNA and RNA strands. When the DNA strand of the hybrid is Py ric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75af5cf1bad2ab73026a349623fb7342
http://hdl.handle.net/10261/184539
http://hdl.handle.net/10261/184539
Publikováno v:
Nature Catalysis
DNAzymes have become attractive due to their potential biomedical and biotechnological applications, as well as their advantages in terms of stability, efficiency and synthetic accessibility with respect to protein or RNA catalysts. However, a lack o
Autor:
Dani Sánchez, Núria Villegas, Modesto Orozco, Federica Battistini, Isabelle Brun-Heath, Montserrat Terrazas
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Chemical Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Chemical Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Here we present 2shRNA, a shRNA-based nanobinder, which can simultaneously attack two therapeutic targets involved in drug resistance pathways and can additionally bind accessory molecules such as cell targeting peptides or fluorophores. We create 2s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be5a7c98ff076cb0e55fddc94d8e74b
http://hdl.handle.net/2445/127394
http://hdl.handle.net/2445/127394
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
© 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. The stability of DNA is highly dependent on the properties of the surrounding solvent, such as ionic strength, pH, and the presence of denaturants and osmolytes. Addition of pyridine is known to u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c53cbe413ded272a9e58775430b913c
http://hdl.handle.net/2445/183793
http://hdl.handle.net/2445/183793