Origins of context-dependent gene repression by capicua.

Autor: Marta Forés, Leiore Ajuria, Núria Samper, Sergio Astigarraga, Claudia Nieva, Rona Grossman, Sergio González-Crespo, Ze'ev Paroush, Gerardo Jiménez

Publikováno v: PLoS Genetics, Vol 11, Iss 1, p e1004902 (2015)

Receptor Tyrosine Kinase (RTK) signaling pathways induce multiple biological responses, often by regulating the expression of downstream genes. The HMG-box protein Capicua (Cic) is a transcriptional repressor that is downregulated in response to RTK

Externí odkaz: https://doaj.org/article/df9a41c48481449fa41a6cb4b62a5d3f

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

Autor: Mariano Barbacid, Matthias Drosten, Sergio González-Crespo, Gerardo Jiménez, Leiore Ajuria, Núria Samper, Lucía Simón-Carrasco, Marta Forés

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Genetics, Vol 13, Iss 3, p e1006622 (2017)
PLoS Genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0094e3a09e55c9184268abdc4d535b8
http://hdl.handle.net/20.500.12105/7232

A Systematic Ensemble Approach to Thermodynamic Modeling of Gene Expression from Sequence Data

Autor: Núria Samper, Christine Rushlow, Bomyi Lim, Hang Lu, Md. Abul Hassan Samee, Stanislav Y. Shvartsman, Gerardo Jiménez, Saurabh Sinha

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Summary To understand the relationship between an enhancer DNA sequence and quantitative gene expression, thermodynamics-driven mathematical models of transcription are often employed. These "sequence-to-expression" models can describe an incomplete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4018a45f9d039879feb4a850c0e9145b
http://hdl.handle.net/10261/133745

Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila

Autor: María José Andreu, Leiore Ajuria, Gerardo Jiménez, Núria Samper, Sonsoles Campuzano, Esther González-Pérez, Sergio González-Crespo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Dorsoventral (DV) axis formation in Drosophila begins with selective activation of EGFR, a receptor tyrosine kinase (RTK), in dorsal-anterior (DA) ovarian follicle cells. A critical event regulated by EGFR signaling is the repression of the sulfotran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237b04977a8db7ef7d093340ffae90fe
http://hdl.handle.net/10261/53254

Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila

Autor: Dennis Kuo, Claudia Nieva, Clint J. Winkler, Sergio González-Crespo, Gerardo Jiménez, Albert J. Courey, Aharon Helman, Leiore Ajuria, Ze'ev Paroush, María José Andreu, Núria Samper

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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et al.
RTK/Ras/MAPK signaling pathways play key functions in metazoan development, but how they control expression of downstream genes is not well understood. In Drosophila, it is generally assumed that most transcriptional responses to RTK sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e39a53b0211278530636408151eb503
https://europepmc.org/articles/PMC3035094/