Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nóra Kucsma"'
Autor:
Gábor M. Harami, János Pálinkás, Zoltán J. Kovács, Bálint Jezsó, Krisztián Tárnok, Hajnalka Harami-Papp, József Hegedüs, Lamiya Mahmudova, Nóra Kucsma, Szilárd Tóth, Gergely Szakács, Mihály Kovács
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110788- (2024)
Summary: Human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) plays central roles in DNA repair. Here, we show that purified hSSB1 undergoes redox-dependent liquid-liquid phase separation (LLPS) in the presence of single-stranded DNA or R
Externí odkaz:
https://doaj.org/article/f900f8a1e9714c37a521aa897d38d7b2
Autor:
Adrienn Molnár, Gabriel Stefan Horkovics-Kováts, Nóra Kucsma, Zsuzsanna Szegő, Boglárka Tauber, Attila Egri, Zoltán Szkupien, Bálint András Deák, James S. McKenzie, Julianna Thuróczy, Richard Schäffer, Gitta Schlosser, Gergely Szakács, Júlia Balog
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7752 (2024)
Breast cancer, a complex disease with a significant prevalence to form metastases, necessitates novel therapeutic strategies to improve treatment outcomes. Here, we present the results of a comparative molecular study of primary breast tumours, their
Externí odkaz:
https://doaj.org/article/ab7b325035734b91ad3bef4fe6218aae
Autor:
Éva Bakos, Orsolya Német, Nóra Kucsma, Natália Tőkési, Bruno Stieger, Elisabeth Rushing, Anna-Mária Tőkés, Péter Kele, Gábor E. Tusnády, Csilla Özvegy-Laczka
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Organic anion transporting polypeptide 3A1 (OATP3A1, encoded by the SLCO3A1 gene) is a prostaglandin, oligopeptide, and steroid/thyroid hormone transporter with wide tissue distribution, expressed, e.g., in the human brain and testis. Although the ph
Externí odkaz:
https://doaj.org/article/b0f180d66ed14196b1976c31c22ac564
Autor:
Tamás Langó, Zoltán Gergő Pataki, Lilla Turiák, András Ács, Julia Kornélia Varga, György Várady, Nóra Kucsma, László Drahos, Gábor E. Tusnády
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Transmembrane proteins (TMP) play a crucial role in several physiological processes. Despite their importance and diversity, only a few TMP structures have been determined by high-resolution protein structure characterization methods so far.
Externí odkaz:
https://doaj.org/article/59f84953b9054598b7843cb7e89e568f
Autor:
Anna Kulin, Nóra Kucsma, Balázs Bohár, Botond Literáti-Nagy, László Korányi, Judit Cserepes, Anikó Somogyi, Balázs Sarkadi, Edit Szabó, György Várady
Publikováno v:
Biology, Vol 11, Iss 11, p 1669 (2022)
The human GLUT1 (SLC2A1) membrane protein is the key glucose transporter in numerous cell types, including red cells, kidney, and blood-brain barrier cells. The expression level of this protein has a role in several diseases, including cancer and Alz
Externí odkaz:
https://doaj.org/article/7b05fdae17d44e46b15a56baf3d63ca9
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10599 (2022)
The multidrug transporter ABCB1 (MDR1, Pgp) plays an important role in the absorption, distribution, metabolism, and elimination of a wide range of pharmaceutical compounds. Functional investigation of the ABCB1 expression is also essential in many d
Externí odkaz:
https://doaj.org/article/eef06164cb9d4c29a7043b3f30e5a650
Autor:
Lilla Hámori, Gyöngyi Kudlik, Kornélia Szebényi, Nóra Kucsma, Bálint Szeder, Ádám Póti, Ferenc Uher, György Várady, Dávid Szüts, József Tóvári, András Füredi, Gergely Szakács
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1185 (2020)
Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. By the age of 80, the estimated risk for breast cancer for women with germline BRCA1 or BRCA2 mutations is around 80%. Genetically engineered BRCA
Externí odkaz:
https://doaj.org/article/a0c8dcd06f214d109a647d705d484582
Autor:
Edit Szabó, Dóra Türk, Ágnes Telbisz, Nóra Kucsma, Tamás Horváth, Gergely Szakács, László Homolya, Balázs Sarkadi, György Várady
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190629 (2018)
ABC multidrug transporters are key players in cancer multidrug resistance and in general xenobiotic elimination, thus their functional assays provide important tools for research and diagnostic applications. In this study we have examined the potenti
Externí odkaz:
https://doaj.org/article/9464bd06305d48278d5000f204f0913c
Autor:
Gergely Szakács, József Tóvári, László Cervenak, Nóra Kucsma, Dóra Türk, Veronika F.S. Pape, Kornélia Szebényi, Szilárd Tóth, András Füredi
Supplementary Figure 1: MDR-selective toxicity of NSC297366 in additional MDR cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68443fa44c4682e40a6e723b9dd6976c
https://doi.org/10.1158/1535-7163.22508104.v1
https://doi.org/10.1158/1535-7163.22508104.v1
Autor:
Gergely Szakács, József Tóvári, László Cervenak, Nóra Kucsma, Dóra Türk, Veronika F.S. Pape, Kornélia Szebényi, Szilárd Tóth, András Füredi
Structure of the compounds analyzed in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909a5e7a4010fa963291ae12275eb74a
https://doi.org/10.1158/1535-7163.22508092
https://doi.org/10.1158/1535-7163.22508092